PE-A*02:03/Human TP53 (LAPPQHLIRV) MHC Tetramer

Name: PE-A*02:03/Human TP53 (LAPPQHLIRV) MHC Tetramer
SKU: MHC-LC3123
Rating: 5 (1 reviews)

CAT#: MHC-LC3123

This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human TP53 of peptide LAPPQHLIRV covering 188-197 and A*02:03 molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.

Gene Expression

RNA Expression Figure 7 RNA cell line category: Low cell line specificity

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000141510-TP53

Subcellular Location Figure 1 IF staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & vesicles.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/39239/651_G2_2_selected.jpg

Subcellular Location Figure 2 IF staining of human cell line A549

Immunofluorescent staining of human cell line A549 shows localization to nucleoplasm.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63532/1113_C11_2_selected.jpg

Subcellular Location Figure 3 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm, cytosol & mitochondria.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/79965/1999_E7_4_selected.jpg

Subcellular Location Figure 4 IF staining of human cell line U-251 MG

Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & vesicles.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/39238/656_H2_1_red_green.jpg

Normal Tissue Figure 5 Oral mucosa

Squamous epithelial cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Nuclear

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2973/6986_A_8_1.jpg

Normal Tissue Figure 6 Colon

Enterocytes
Staining: Medium
Intensity: Strong
Quantity: <25%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2973/6986_A_9_3.jpg

RNA Expression Figure 7 RNA cell line category: Low cell line specificity

Cell lines ordered by descending RNA expression order.

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Specifications

Allele
A*02:03

Class
Class I

MHC Species
Human

Antigen
TP53

Antigen Species
Human

Peptide
LAPPQHLIRV

Range
188-197

Conjugate
PE

Application
FCM

Target

Antigen Introduction
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]

Alternative Names
TP53; Human Cellular tumor antigen p53; P53; BCC7; LFS1; TRP53

Gene ID
7157

UniProt ID
P04637

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Related Diseases

EGFR Tyrosine Kinase Inhibitor Resistance

Downloadable Resources

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Datasheet

Datasheet - MHC-LC3123.pdf

MSDS

MSDS - MHC-LC3123.pdf

COA

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