APC-E*01:01/Human HLA-A*02, A*24 leader R5K (VMAPKTLVL) MHC Tetramer
CAT#: MHC-LC667
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of HLA-A*02, A*24 leader R5K-derived peptide of VMAPKTLVL sequence covering 3-11 and E*01:01 molecule. The pMHC tetramer recognizes human CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/78470/1733_C1_2_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enhanced (A-431, fHDF/TERT166, HBEC3-KT, RPMI-8226, U-266/70)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000206503-HLA-A
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Specifications
- Allele
- E*01:01
- Class
- Class I
- MHC Species
- Human
- Antigen
- HLA-A*02, A*24 leader R5K
- Antigen Species
- Human
- Peptide
- VMAPKTLVL
- Range
- 3-11
- Conjugate
- APC
- Application
- FCM
Target
- Antigen Introduction
- HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described.
- Alternative Names
- HLA-A; Major histocompatibility complex, class I, A; HLAA
- Gene ID
- 911829
- UniProt ID
- Q05320
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