anti-HLA-A immunotoxin Fib75 (IgG)-α-sar (AGTO-L022F)

This immunotoxin was achieved by conjugating/fusing the anti-HLA-A monoclonal antibody to α-sarcin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to human bladder carcinoma cells. Once bind, alpha-Sarcin enters into the cells by receptor-mediated endocytosis and interacts with a single bond in the targeted ribosome and breaks it, causing the ribosome to be inactivated. It was designed for treatment of bladder carcinoma.      

Species Reactivity
Molecule Class
L kappa; IgG2a-α-sar
Toxin Description
Alpha-Sarcin is a ribosome-inactivating protein produced in the mold Aspergillus giganteus. Specifically, alpha-sarcin cleaves the a portion of ribosomal RNA that forms the small ribosomal substrate. The high specificity of alpha-sarcin and its efficiency of cleavage are point of study and also account for this protein's very high toxicity level.
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
Bladder cancer
Alternative Names
antigen presenting molecule; FLJ26655; HLA class I histocompatibility antigen, A-1 alpha chain; HLAA; leukocyte antigen class I-A; major histocompatibility complex, class I, A; MHC class I antigen HLA-A heavy chain; HLA class I-related plasma membrane antigen

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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