anti-HLA-A immunotoxin Fib75 (IgG)-α-sar (CAT#: AGTO-L022F)
This immunotoxin was achieved by conjugating/fusing the anti-HLA-A monoclonal antibody to α-sarcin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to human bladder carcinoma cells. Once bind, alpha-Sarcin enters into the cells by receptor-mediated endocytosis and interacts with a single bond in the targeted ribosome and breaks it, causing the ribosome to be inactivated. It was designed for treatment of bladder carcinoma.
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Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/78470/1733_C1_2_selected.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/78470/1733_C1_2_selected.jpg
Figure 2 RNA cell line category: Cell line enhanced (A-431, fHDF/TERT166, HBEC3-KT, RPMI-8226, U-266/70)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000206503-HLA-A
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000206503-HLA-A
Specifications
- Host Species
- Mouse
- Species Reactivity
- Human
- Clone
- Fib75
- Molecule Class
- L kappa; IgG2a-α-sar
- Toxin Description
- Alpha-Sarcin is a ribosome-inactivating protein produced in the mold Aspergillus giganteus. Specifically, alpha-sarcin cleaves the a portion of ribosomal RNA that forms the small ribosomal substrate. The high specificity of alpha-sarcin and its efficiency of cleavage are point of study and also account for this protein's very high toxicity level.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- Bladder cancer
Target
- Alternative Names
- antigen presenting molecule; FLJ26655; HLA class I histocompatibility antigen, A-1 alpha chain; HLAA; leukocyte antigen class I-A; major histocompatibility complex, class I, A; MHC class I antigen HLA-A heavy chain; HLA class I-related plasma membrane antigen; Bladder cance; HLA class I-related plasma membrane antigen; Bladder cance α-sar; α-sarcin
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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