anti-HLA-A immunotoxin Fib75 (IgG)-α-sar (CAT#: AGTO-L022F)
This immunotoxin was achieved by conjugating/fusing the anti-HLA-A monoclonal antibody to α-sarcin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to human bladder carcinoma cells. Once bind, alpha-Sarcin enters into the cells by receptor-mediated endocytosis and interacts with a single bond in the targeted ribosome and breaks it, causing the ribosome to be inactivated. It was designed for treatment of bladder carcinoma.
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Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/78470/1733_C1_2_selected.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/78470/1733_C1_2_selected.jpg
Figure 2 RNA cell line category: Cell line enhanced (A-431, fHDF/TERT166, HBEC3-KT, RPMI-8226, U-266/70)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000206503-HLA-A
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000206503-HLA-A
Specifications
- Host Species
- Mouse
- Species Reactivity
- Human
- Clone
- Fib75
- Molecule Class
- L kappa; IgG2a-α-sar
- Toxin Description
- Alpha-Sarcin is a ribosome-inactivating protein produced in the mold Aspergillus giganteus. Specifically, alpha-sarcin cleaves the a portion of ribosomal RNA that forms the small ribosomal substrate. The high specificity of alpha-sarcin and its efficiency of cleavage are point of study and also account for this protein's very high toxicity level.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- Bladder cancer
Target
- Alternative Names
- antigen presenting molecule; FLJ26655; HLA class I histocompatibility antigen, A-1 alpha chain; HLAA; leukocyte antigen class I-A; major histocompatibility complex, class I, A; MHC class I antigen HLA-A heavy chain; HLA class I-related plasma membrane antigen; Bladder cance; HLA class I-related plasma membrane antigen; Bladder cance α-sar; α-sarcin
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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|---|---|---|---|
| MOB-500-F(E) | Recombinant Anti-human HLA-A Antibody Fab Fragment | Neut, IF, FuncS | Fab |
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| PFBC-072 | Human Anti-HLA-A Recombinant Antibody (clone HYB3); Fab Fragment | WB, ELISA | Human Fab |
| HPAB-1096WJ-F(E) | Mouse Anti-HLA-A Recombinant Antibody; Fab Fragment (HPAB-1096WJ-F(E)) | ELISA | Mouse Fab |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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