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HLA-A
Loading...Anti-HLA-A Products
- Recombinant Human Anti-HLA-A Antibody scFv Fragment (T1) (PABX-105-S (P))
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- Derivation: Human
- Species Reactivity: Human
- Type: scFv
- Application: WB, ELISA, FuncS
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- Class: Class II
- Antigen: HLA-A2
- Antigen Species: Human
- Peptide: VGSDWRFLRGYHQYA
- Conjugate: PE
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- Class: Class I
- Antigen: HLA-A*02, A*24 leader R5K
- Antigen Species: Human
- Peptide: VMAPKTLVL
- Conjugate: PE
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- Class: Class I
- Antigen: HLA-A leader 3-11
- Antigen Species: Human
- Peptide: VMAPRTLVL
- Conjugate: PE
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- Class: Class I
- Antigen: HLA-A*02, A*24 leader R5K
- Antigen Species: Human
- Peptide: VMAPKTLVL
- Conjugate: PE
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- Class: Class I
- Antigen: HLA-A leader 3-11
- Antigen Species: Human
- Peptide: VMAPRTLVL
- Conjugate: PE
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- Class: Class I
- Antigen: HLA-A*02, A*24 leader
- Antigen Species: Human
- Peptide: VMAPRTLVL
- Conjugate: PE
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- Class: Class I
- Antigen: HLA-A*02, A*24 leader R5K
- Antigen Species: Human
- Peptide: VMAPKTLVL
- Conjugate: APC
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- Class: Class I
- Antigen: HLA-A*02, A*24 leader
- Antigen Species: Human
- Peptide: VMAPRTLVL
- Conjugate: PE
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- Class: Class II
- Antigen: HLA-A*02:01
- Antigen Species: Human
- Peptide: GSDARFLRGYHLYA
- Conjugate: PE
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- Class: Class I
- Antigen: HLA-A*02, A*24 leader R5K
- Antigen Species: Human
- Peptide: VMAPKTLVL
- Conjugate: APC
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- Class: Class II
- Antigen: HLA-A2
- Antigen Species: Human
- Peptide: VGSDWRFLRGYHQYA
- Conjugate: BV421
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- Class: Class II
- Antigen: HLA-A2
- Antigen Species: Human
- Peptide: VGSDWRFLRGYHQYA
- Conjugate: APC
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- Class: Class II
- Antigen: HLA-A*02:01
- Antigen Species: Human
- Peptide: GSDARFLRGYHLYA
- Conjugate: APC
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- Class: Class II
- Antigen: HLA-A*02:01
- Antigen Species: Human
- Peptide: GSDARFLRGYHLYA
- Conjugate: BV421
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- Mouse Anti-HLA-A Recombinant Antibody (HPAB-1096WJ) (HPAB-1096WJ)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA
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- Mouse Anti-HLA-A Recombinant Soluble TCR (clone CBY1) (scTCR-002YF-S(P))
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- Species Reactivity: Human
- Epitope: RYLENGKETL
- MHC: H2-Kd
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- HLA-E*01:01/Human HLA-A (VMAPRTLVL) MHC Monomer (MHC-YF184)
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- Class: Class I
- Antigen: HLA-A
- Antigen Species: Human
- Peptide: VMAPRTLVL
- Conjugate: Biotin
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- Mouse Anti-HLA-A Recombinant Antibody (clone YTH 862.2) (FAMAB-1361CQ)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: IP, FC, IF
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- Mouse Anti-HLA-A Antibody (clone YTH 862.2), mRNA (FAMAB-1361CQ-mRNA)
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- Species Reactivity: Human
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- Mouse Anti-HLA-A Antibody (clone Fib75), mRNA (AGTO-L022F-mRNA)
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- Species Reactivity: Human
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- Human Anti-HLA-A Antibody, mRNA (PABX-105-mRNA) (PABX-105-mRNA)
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- Species Reactivity: Human
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- Human Anti-HLA-A Antibody (clone HYB3), mRNA (PABC-072-mRNA)
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- Species Reactivity: Human
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- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: ELISA, FC, IHC, ICC, IP, WB, Immuno-cryo-EM
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, FC, IHC, ICC, IP, WB, Immuno-cryo-EM
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- Mouse Anti-HLA-A Antibody (clone BRA-23/9) (ZG-1014F)
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- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: FC, IHC-Fr
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- Recombinant Mouse Anti-HLA-A Soluble TCR (CBY1) (C-Cys) (VS-0622-YF3185)
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- Species Reactivity: Human
- Epitope: RYLENGKETL
- MHC: H2-Kd
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- AbPlus™ Anti-HLA-A Magnetic Beads (HC10) (VS-0424-XY124)
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- Target: HLA-A
- Target Species: Human
- Application: IP, Protein Purification
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- Recombinant Anti-human HLA-A Antibody (MOB-500)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: WB, FC, FuncS
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- PE-H2-Kd/Human HLA-A (RYLENGKETL) MHC Tetramer (MHC-LC2631)
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- Class: Class I
- Antigen: HLA-A
- Antigen Species: Human
- Peptide: RYLENGKETL
- Conjugate: PE
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- PE-B*15:01/Human HLA-A (VGYVDDTQF) MHC Tetramer (MHC-LC4476)
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- Class: Class I
- Antigen: HLA-A
- Antigen Species: Human
- Peptide: VGYVDDTQF
- Conjugate: PE
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- PE-B*58:01/Human HLA-A (VGYVDDTQF) MHC Tetramer (MHC-LC4477)
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- Class: Class I
- Antigen: HLA-A
- Antigen Species: Human
- Peptide: VGYVDDTQF
- Conjugate: PE
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- APC-H2-Kd/Human HLA-A (RYLENGKETL) MHC Tetramer (MHC-LC4492)
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- Class: Class I
- Antigen: HLA-A
- Antigen Species: Human
- Peptide: RYLENGKETL
- Conjugate: APC
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- Mouse Anti-HLA-A Recombinant Antibody (clone 2D7sc(Fv)2) (HPAB-0349CQ)
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- Species Reactivity: Human
- Type: Mouse sc(Fv)2
- Application: WB, FC
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- Rabbit Anti-HLA-A Recombinant Antibody (clone JF10-38) (MRO-0996-CN)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
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- Recombinant Human Anti-HLA-A Antibody (T1) (PABX-105)
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- Derivation: Human
- Species Reactivity: Human
- Type: IgG
- Application: WB, ELISA, FuncS
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- Recombinant Mouse Anti-HLA-A Soluble TCR (CBY1) (KIH) (VS-0622-YF5893)
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- Species Reactivity: Human
- Epitope: RYLENGKETL
- MHC: H2-Kd
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- Mouse Anti-HLA-A Recombinant Antibody; scFv Fragment (HPAB-1096WJ-S(P)) (HPAB-1096WJ-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
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- Recombinant Anti-human HLA-A Antibody Fab Fragment (MOB-500-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: Neut, IF, FuncS
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- Recombinant Anti-human HLA-A Antibody scFv Fragment (MOB-500-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: ELISA, WB, IF, FuncS
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- Recombinant Human Anti-human HLA-A Antibody Fab Fragment (MHH-500-F(E))
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- Derivation: Human
- Species Reactivity: Human
- Type: Fab
- Application: WB, IF, FuncS
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- Recombinant Human Anti-human HLA-A Antibody scFv Fragment (MHH-500-S(P))
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- Derivation: Human
- Species Reactivity: Human
- Type: scFv
- Application: ELISA, WB, FuncS
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- anti-HLA-A immunotoxin Fib75 (IgG)-α-sar (AGTO-L022F)
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
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- Target: HLA-A2.1
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Mouse
- Cytokine 1 Species: Human
- Molecule Class: IL2-IgG2b
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- Target: HLA-A2.1
- Species Reactivity: Human
- Cytokine 1: TNF
- Host: Mouse
- Cytokine 1 Species: Human
- Molecule Class: TNF-IgG2b
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- Mouse Anti-HLA-A Recombinant Antibody; Fab Fragment (HPAB-1096WJ-F(E)) (HPAB-1096WJ-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA
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- Anti-HLA-A Antibody Prodrug, Protease Activated (HYB3) (VS-1025-YC89)
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- Species Reactivity: Human
- Host Animal: Human
- Target: HLA-A
- Application: ISZ, Cyt, FuncS
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- CytoStream™ Mouse Anti-HLA-A Recombinant Antibody (clone 1082C5) (VS-0225-XY119)
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- Species Reactivity: Human
- Type: Mouse IgG1, kappa
- Application: FC
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- Anti-HLA-A Immunohistochemistry Kit (VS-0325-XY1028)
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- Species Reactivity: Human
- Target: HLA-A
- Application: IHC
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- Species Reactivity: Human
- Target: HLA-A
- Host Animal: Human
- Application: ELISA, FC, Cell-uptake
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- Anti-Human HLA-A Immunohistochemistry Kit (VS-0525-XY3164)
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- Species Reactivity: Human, Bovine, Monkey
- Target: HLA-A
- Application: IHC
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More Infomation
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For Research Use Only. Not For Clinical Use.
Background
The HLA class I antigen is formed by a heterodimer of a 45-KD α comprising three domains (α1, α2, α3), and a 12-KD β2 microglobulin. The main role of the HLA molecule is to present CD8+T cells with antigenic peptides formed from about eight to ten amino acids and produced inside cells.
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Transporters
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Proximal enterocytes, Ductal cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (A-431, fHDF/TERT166, HBEC3-KT, RPMI-8226, U-266/70)
Interaction
Heterotrimer that consists of an alpha chain HLA-A, a beta chain B2M and a peptide (peptide-HLA-A-B2M) (PubMed:7504010, 7679507, 21943705, 19177349, 24395804, 26758806, 7504010, 7506728, 8805302, 7694806, 7935798, 9177355, 18275829, 22245737, 28250417, 11502003, 8906788, 19542454). Early in biogenesis, HLA-A-B2M dimer interacts with the components of the peptide-loading complex composed of TAPBP, TAP1-TAP2, TAPBPL, PDIA3/ERP57 and CALR (PubMed:21263072). Interacts with TAP1-TAP2 transporter via TAPBP; this interaction is obligatory for the loading of peptide epitopes delivered to the ER by TAP1-TAP2 transporter (PubMed:8805302, 8630735, 21263072). Interacts with TAPBPL; TAPBPL binds peptide-free HLA-A-B2M complexes or those loaded with low affinity peptides, likely facilitating peptide exchange for higher affinity peptides (PubMed:26869717). Only optimally assembled peptide-HLA-B2M trimer translocates to the surface of antigen-presenting cells, where it interacts with TCR and CD8 coreceptor on the surface of T cells. HLA-A (via polymorphic alpha-1 and alpha-2 domains) interacts with antigen-specific TCR (via CDR3 domains) (PubMed:22245737, 12796775, 18275829). One HLA-A molecule (mainly via nonpolymorphic alpha-3 domain) interacts with one CD8A homodimer (via CDR-like loop); this interaction insures peptide-HLA-A-B2M recognition by CD8-positive T cells only (PubMed:9177355, 2784196). Alleles A*23:01; A*24:02 and A*32:01 interact (via Bw4 motif) with KIR3DL1 on NK cells; this interaction is direct. (Microbial infection) Interacts with HHV-8 MIR1 protein. (Microbial infection) Interacts with HTLV-1 accessory protein p12I.
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