AbPlus™ Anti-HLA-A Magnetic Beads (HC10)
CAT#: VS-0424-XY124
The AbPlus Anti-HLA-A Magnetic Beads (HC10) is an innovative affinity resin which is bound with anti-HLA-A specific antibody (HC10). The beads were designed for small-scale affinity purification and immunoprecipitation (IP) of HLA-A protein under native and denaturing conditions.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/78470/1733_C1_2_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enhanced (A-431, fHDF/TERT166, HBEC3-KT, RPMI-8226, U-266/70)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000206503-HLA-A
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Specifications
- Applications
- Immunoprecipitation, Protein Purification
- Matrix
- Magrose bead (> 50 μmol/mL gel)
- Bead Ligand
- Anti-HLA-A specific antibody (HC10)
- Target
- HLA-A
- Target Species
- Human
- Antibody Clone
- HC10
- Bead Capacity
- 20-30 mg/mL binding antibody
- Bead size
- 10-37 μm
- Stability
- pH 2-14
- Format
- 20% Suspension
- Buffer
- PBS, pH 7.4, with 1% BSA
- Preservative
- 0.03% Proclin 300
- Storage
- Stored at 4°C, and is stable for up to 2 years. Do not centrifuge, dry or freeze the magnetic beads.
Applications
- Application Notes
- The beads are in suspension and will settle upon storage. Prior to use, mix the vial gently (do not vortex) to ensure delivery of proper bead volume.
Target
- Introduction
- HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described.
- Alternative Names
- Major Histocompatibility Complex, Class I, A; HLA Class I Histocompatibility Antigen, A-1 Alpha Chain; HLAA; HLA Class I Histocompatibility Antigen, A-10 Alpha Chain; HLA Class I Histocompatibility Antigen, A-28 Alpha Chain; HLA Class I Histocompatibility Antigen, A-9 Alpha Chain; MHC Class I Antigen HLA-A Heavy Chain; Leukocyte Antigen Class I-A; MHC Class I Antigen A*11; MHC Class I Antigen A*23; MHC Class I Antigen A*24; MHC Class I Antigen A*25; MHC Class I Antigen A*26; MHC Class I Antigen A*29; MHC Class I Antigen A*30; MHC Class I Antigen A*31; MHC Class I Antigen A*32; MHC Class I Antigen A*33; MHC Class I Antigen A*34; MHC Class I Antigen A*36; MHC Class I Antigen A*43
- Gene ID
- 3105
- UniProt ID
- P01891
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Datasheet
MSDS
COA
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