APC-H2-Kd/Human HLA-A (RYLENGKETL) MHC Tetramer
CAT#: MHC-LC4492
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of human HLA-A of peptide RYLENGKETL covering 194-203 and H2-Kd molecule. The pMHC tetramer recognizes CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/78470/1733_C1_2_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enhanced (A-431, fHDF/TERT166, HBEC3-KT, RPMI-8226, U-266/70)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000206503-HLA-A
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Specifications
- Allele
- H2-Kd
- Class
- Class I
- MHC Species
- Mouse
- Antigen
- HLA-A
- Antigen Species
- Human
- Peptide
- RYLENGKETL
- Range
- 194-203
- Conjugate
- APC
- Application
- FCM
Target
- Antigen Introduction
- The major histocompatibility complex (MHC) is a set of cell surface proteins essential for the acquired immune system to recognize foreign molecules in vertebrates, which in turn determines histocompatibility. The main function of MHC molecules is to bind to antigens derived from pathogens and display them on the cell surface for recognition by the appropriate T-cells. MHC molecules mediate interactions of leukocytes, also called white blood cells (WBCs), which are immune cells, with other leukocytes or with body cells. The MHC determines compatibility of donors for organ transplant, as well as one's susceptibility to an autoimmune disease via crossreacting immunization. The human MHC is also called the HLA (human leukocyte antigen) complex (often just the HLA). The mouse MHC is called the H-2 complex or H-2.
- Alternative Names
- HLA-A; HLA class I histocompatibility antigen
- UniProt ID
- Q9TQ84
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COA
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