Anti-HIV-1 antibody is a Human of Fab class that binds to an HIV-1. It developed From individual infected with V3 HIV-1.
Figure 1 Relative affinities of mAbs binding to the mimotope as measured by 50% of maximal binding (‘‘halfmax’’) to plates coated with the biotinylated mimotope at a concentration of 1.0 mg/ml. Lower half-max values reflect higher relative affinities.
Gorny, M. K., Sampson, J., Li, H., Jiang, X., Totrov, M., Wang, X. H., ... & Cardozo, T. (2011). Human anti-V3 HIV-1 monoclonal antibodies encoded by the VH5-51/VL lambda genes define a conserved antigenic structure. PloS one, 6(12), e27780.
Figure 2 Structural similarity of the antigen-binding sites of VH5-51 encoded anti-V3 mAbs.
(A) A structural superimposition of the Ca atoms of the Fab variable domains of complexes 1006/MN (green), 2219/MN (cyan), 2557/NY5 (magenta), 2558/MN (yellow), and 4025/ConA (salmon). Note the domains of CDR H1, H2, L1 and L2 superimposed well, while that of CDR L3 and H3 is more structurally divergent. (B) Same superimposition as that in panel (A) but with the key contact residues of the mAbs labeled (all contact residues are shown in Tables 4 and 5). The position of the V3 is illustrated as a dashed line. (C) and (D) Structural details of the antigen combining sites of the light (C) and heavy chains (D) in the five complexes.
Gorny, M. K., Sampson, J., Li, H., Jiang, X., Totrov, M., Wang, X. H., ... & Cardozo, T. (2011). Human anti-V3 HIV-1 monoclonal antibodies encoded by the VH5-51/VL lambda genes define a conserved antigenic structure. PloS one, 6(12), e27780.
Figure 3 Schematic of antigenic profile analysis on intact liposomes compared to soluble trimers. bnAb (PGT121, PGT145, PGT151, VRC01) and non-nAb (B6, 39 F, 4025) binding profiles of non-covalent and covalent MD39 liposomes. mouse serum (blue) at 37 °C (n = 3).
Tokatlian, T., Kulp, D. W., Mutafyan, A. A., Jones, C. A., Menis, S., Georgeson, E., ... & Yun, D. S. (2018). Enhancing humoral responses against HIV envelope trimers via nanoparticle delivery with stabilized synthetic liposomes. Scientific reports, 8(1), 16527.
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CAT | Product Name | Application | Type |
---|---|---|---|
NAB-1889-sdAb | Recombinant Anti-HIV-1 VHH Single Domain Antibody | WB, ICC, ChiP, FA, ELISA | Llama VHH |
PNBL-038 | Recombinant Anti-HIV-1 C186 gp120 VHH Single Domain Antibody (A12) | WB, FuncS | Llama VHH |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-068 | Anti-HIV-1 Recombinant Antibody (Suvizumab) | WB, ELISA, IP, FC, FuncS, Neut, IF | IgG1 - kappa |
PABX-094-S (P) | Recombinant Human Anti-HIV-1 Antibody scFv Fragment (Fab4025) | WB, ELISA, FuncS | scFv |
PABX-099-S (P) | Recombinant Human Anti-HIV-1 Antibody scFv Fragment | FC, FuncS | scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
AGTO-G037E | Anti-HIV-1 immunotoxin 3B3 (scFv)-PE | Cytotoxicity assay, Function study | |
AGTO-G037D | Anti-HIV-1 immunotoxin 3B3 (scFv)-DT | Cytotoxicity assay, Function study |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBL-140 | Human Anti-HIV-1 Recombinant Antibody (clone VRC26.25); scFv Fragment | WB, ELISA, Neut, FuncS | Human scFv |
FAMAB-0176CQ-S(P) | Mouse Anti-HIV-1 Recombinant Antibody (clone KEL10); scFv Fragment | ELISA, Neut | Mouse scFv |
HPAB-AP363-YC-S(P) | Human Anti-HIV-1 Recombinant Antibody (clone A2); scFv Fragment | ELISA, Neut | Human scFv |
HPAB-1988-FY-S(P) | Human Anti-HIV-1 Recombinant Antibody (clone 2G9); scFv Fragment | FC, ELISA | Human scFv |
HPAB-1989-FY-S(P) | Human Anti-HIV-1 Recombinant Antibody (clone 9F11); scFv Fragment | FC, ELISA | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBL-140 | Human Anti-HIV-1 Recombinant Antibody (clone VRC26.25); Fab Fragment | WB, ELISA, Neut, FuncS | Human Fab |
FAMAB-0176CQ-F(E) | Mouse Anti-HIV-1 Recombinant Antibody (clone KEL10); Fab Fragment | ELISA, Neut | Mouse Fab |
HPAB-0158-YJ-F(E) | Human Anti-HIV-1 Recombinant Antibody; Fab Fragment (HPAB-0158-YJ-F(E)) | ELISA, Neut, Inhib | Human Fab |
HPAB-1988-FY-F(E) | Human Anti-HIV-1 Recombinant Antibody (clone 2G9); Fab Fragment | FC, ELISA | Human Fab |
HPAB-1989-FY-F(E) | Human Anti-HIV-1 Recombinant Antibody (clone 9F11); Fab Fragment | FC, ELISA | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PABX-001 | Recombinant Human Anti-HIV-1 Antibody (1281) | WB, FuncS, Neut, SPR | IgG |
PABX-008-S (P) | Recombinant Mouse Anti-HIV-1 Antibody scFv Fragment | WB, IHC, IF, FuncS | scFv |
PABX-095-S (P) | Recombinant Mouse Anti-HIV-1 Antibody scFv Fragment (Fab59.1) | Neut, ELISA, FuncS | scFv |
PABX-001-F (E) | Recombinant Human Anti-HIV-1 Antibody Fab Fragment (1281) | WB, FuncS | Fab |
PABX-087-F(E) | Human Anti-HIV-1 Recombinant Antibody; Fab Fragment (PABX-087-F(E)) | WB, ELISA, FuncS | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PABX-001-S (P) | Recombinant Human Anti-HIV-1 Antibody scFv Fragment (1281) | WB, FuncS | scFv |
PABX-084-F (E) | Recombinant Mouse Anti-HIV-1 Antibody Fab Fragment (83.1) | WB, ELISA, FuncS | Fab |
PABX-089-F (E) | Recombinant Mouse Anti-HIV-1 Antibody Fab Fragment (A10F9) | Neut, FuncS | Fab |
PABX-093-F (E) | Recombinant Mouse Anti-HIV-1 Antibody Fab Fragment (Fab28) | WB, ELISA, FuncS | Fab |
PABX-095-F (E) | Recombinant Mouse Anti-HIV-1 Antibody Fab Fragment (Fab59.1) | Neut, ELISA, FuncS | Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PABX-093-S (P) | Recombinant Mouse Anti-HIV-1 Antibody scFv Fragment (Fab28) | WB, ELISA, FuncS | scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
MHC-LC1376 | PE-A*02:01/HIV-1 (SLFNTVATL) MHC Tetramer | FCM | |
MHC-LC1377 | APC-A*02:01/HIV-1 (SLFNTVATL) MHC Tetramer | FCM | |
MHC-LC1378 | BV421-A*02:01/HIV-1 (SLFNTVATL) MHC Tetramer | FCM |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-4221 | Rabbit Anti-HIV-1 Recombinant Antibody (clone SI300DS) | ELISA, ICC, IF, FC | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0158-YJ | Human Anti-HIV-1 Recombinant Antibody (HPAB-0158-YJ) | ELISA, Neut, Inhib | Chimeric (mouse/human) IgA1, κ |
HPAB-1988-FY | Human Anti-HIV-1 Recombinant Antibody (clone 2G9) | FC, ELISA, Neut | Human IgM |
VS-0423-XY28 | Human Anti-HIV-1 Recombinant Antibody (clone sb1) | ELISA | Human IgG |
VS-0423-XY37 | Human Anti-HIV-1 Recombinant Antibody (clone HBL-2) | ELISA | Human IgM |
VS-0423-XY38 | Human Anti-HIV-1 Recombinant Antibody (clone HBL-3) | ELISA | Human IgM |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-068 | Afuco™ Anti-HIV-1 ADCC Recombinant Antibody (Suvizumab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut | ADCC enhanced antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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