Anti-TF (clone TF-011)-vc-Duostatin-3 ADC (CAT#: ADC-086LZY)

This ADC product is composed of an anti-TF antibody (clone TF-011) conjugated via vc linker to Duostatin-3 (TF-011-vc-Duostatin-3). It has demonstrated a response in epidermal carcinoma, Breast cancer, ovarian cancer treatment by a MOA (Mechanism of Action) of inhibiting cell division by blocking of tubulin polymerization.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Antibody Overview
  • Human Anti-TF IgG1,TF-011
  • Clone
  • TF-011
  • Antibody Isotype
  • IgG1
  • Linker
  • VC (valine-citrulline)
  • Linker Class/Description
  • Class: Enzymatically cleavable linker-Peptide linker
    Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
  • Drug
  • Duostatin-3
  • Drug Class/Description
  • Class: Duostatin-3
    Description: Duostatin-3 is an antimitotic agent that inhibits cell division by blocking of tubulin polymerization. Unlike vcMMAE, duostatin-3 cannot kill neighboring tumor cells when the drug is released from the antibody.

Target

  • Introduction
  • This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
  • Alternative Names
  • F3; coagulation factor III (thromboplastin, tissue factor); TF; TFA; CD142; tissue factor;

Downloads

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Deglycosylated Antibody (Non-glycosylated IgGs)

CAT Product Name Application Type
Gly-178LC Recombinant Anti-Human F3 Antibody (Non-glycosylated) ELISA Human antibody

Recombinant Antibody

CAT Product Name Application Type
MOB-0373MZ Recombinant Mouse Anti-Human Tissue Factor Antibody (clone BIUG-5265) RIA, WB, ELISA Mouse antibody
HPAB-0172CQ Human Anti-F3 Recombinant Antibody (HPAB-0172CQ) ELISA, FC, ADCC Chimeric (mouse/human) IgG1
HPAB-0173CQ Human Anti-F3 Recombinant Antibody (HPAB-0173CQ) ELISA, FC, ADCC Chimeric (mouse/human) IgG1, λ
HPAB-0174CQ Human Anti-F3 Recombinant Antibody (HPAB-0174CQ) ELISA, FC, ADCC Chimeric (mouse/human) IgG1, λ
HPAB-0175CQ Human Anti-F3 Recombinant Antibody (HPAB-0175CQ) ELISA, WB, Inhib Humanized IgG1, κ

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-1226 Hi-Affi™ Rabbit Anti-F3 Recombinant Antibody (clone DS1226AB) WB, IHC-P, ICC, IF Rabbit IgG

Human Antibody

CAT Product Name Application Type
TAB-473CQ Anti-Human F3 Recombinant Antibody (Tisotumab) ELISA, IHC, FC, IP, IF, Inhib IgG1, κ

Epitope-Specific Antibody

CAT Product Name Application Type
EPAF-0573CQ Mouse Anti-F3 Recombinant Antibody (clone hATR-5) ELISA, Inhib Mouse IgG4

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-473CQ Afuco™ Anti-F3 ADCC Recombinant Antibody (Tisotumab), ADCC Enhanced ELISA, IHC, FC, IP, IF, Inhib ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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