Anti-TF (clone TF-011)-vc-Duostatin-3 ADC (CAT#: ADC-086LZY)

• Antibody Overview
• Human Anti-TF IgG1,TF-011

• Clone
• TF-011

• Antibody Isotype
• IgG1

• Linker
• VC (valine-citrulline)

• Linker Class/Description
• Class: Enzymatically cleavable linker-Peptide linker
  Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.

• Drug
• Duostatin-3

• Drug Class/Description
• Class: Duostatin-3
  Description: Duostatin-3 is an antimitotic agent that inhibits cell division by blocking of tubulin polymerization. Unlike vcMMAE, duostatin-3 cannot kill neighboring tumor cells when the drug is released from the antibody.

• Introduction
• This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

• Alternative Names
• F3; coagulation factor III (thromboplastin, tissue factor); TF; TFA; CD142; tissue factor;

• Gene ID
• 2152

• UniProt ID
• P13726

Select a product category from the dropdown menu below to view related products.