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F3

F3 (Coagulation Factor III, Tissue Factor) is a cell surface glycoprotein. Tissue factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, F3 is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of F3: extracellular, transmembrane, and cytoplasmic. F3 is the only one in the coagulation pathway for which a congenital deficiency has not been described.

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