This CAIX specific binding protein (Z-domain of protein A) was investigated by an α-helix shuffling strategy. The primary scaffold protein was from a naive combinatorial library of the three-helix bundle Z domain derived from staphylococcal protein A. A hierarchical library was constructed through selective re-randomization of six amino acid positions in one of the two α-helices of the domain, making up the Taq DNA polymerase binding surface. After selections using monovalent phage display technology, second generation variants were identified having affinities (KD=30 nM) for CAIX as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-707 | Anti-CAIX/CA9 Recombinant Antibody (Girentuximab) | WB, FuncS, IF, Neut, ELISA, FC, IP | IgG1 - kappa |
TAB-H43 | Anti-Human CA9 Recombinant Antibody (Iodine (124I) Girentuximab) | ELISA, IP, IF, Inhib | IgG1 - kappa |
CAT | Product Name | Application | Type |
---|---|---|---|
PABZ-017 | Mouse Anti-CA9 Recombinant Antibody (clone M75) | WB, FuncS | Mouse IgG2b |
HPAB-0782-CN | Human Anti-CA9 Recombinant Antibody (clone G119) | FC, ELISA, Inhib, Cyt, Bioimaging | Human IgG |
HPAB-0784-CN | Human Anti-CA9 Recombinant Antibody (clone G37) | FC, ELISA, Inhib, FuncS, Cyt, Bioimaging, IHC | Human IgG |
MRO-0229-CN | Rabbit Anti-CA9 Recombinant Antibody (clone CBACN-083) | WB, IHC | Rabbit IgG |
VS3-XY145 | Mouse Anti-CA9 Recombinant Antibody (clone 10F7A8) | ELISA, WB, FC | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-1454CL | Anti-Human CA9 Recombinant Antibody (G250) | Cyt | |
TAB-1455CL | Anti-Human CA9 Recombinant Antibody (S239D/I332E) | SPR | |
TAB-1456CL | Anti-Human CA9 Recombinant Antibody (MSC1) | ELISA, FC, Inhib | Fully human antibody |
TAB-1457CL | Anti-Human CA9 Recombinant Antibody (MSC2) | ELISA, FC, Inhib | Fully human antibody |
TAB-1459CL | Anti-Human CA9 Recombinant Antibody (MSC4) | ELISA, FC, Inhib | Fully human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-1458CL-S(P) | Anti-Human CA9 Recombinant Antibody (MSC3); scFv Fragment | FC | Human scFv |
HPAB-0104-LSX-S(P) | Human Anti-CA9 Recombinant Antibody; scFv Fragment (HPAB-0104-LSX-S(P)) | ELISA | Human scFv |
HPAB-0105-LSX-S(P) | Human Anti-CA9 Recombinant Antibody; scFv Fragment (HPAB-0105-LSX-S(P)) | ELISA | Human scFv |
HPAB-0782-CN-S(P) | Human Anti-CA9 Recombinant Antibody (clone G119); scFv Fragment | ELISA, FC | Human scFv |
HPAB-0784-CN-S(P) | Human Anti-CA9 Recombinant Antibody (clone G37); scFv Fragment | ELISA, FC | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-0427 | Hi-Affi™ Rabbit Anti-CA9 Recombinant Antibody (clone DS427AB) | IHC-P, WB | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0104-LSX-F(E) | Human Anti-CA9 Recombinant Antibody; Fab Fragment (HPAB-0104-LSX-F(E)) | ELISA | Human Fab |
HPAB-0105-LSX-F(E) | Human Anti-CA9 Recombinant Antibody; Fab Fragment (HPAB-0105-LSX-F(E)) | ELISA | Human Fab |
HPAB-0355-CN-F(E) | Mouse Anti-CA9 Recombinant Antibody; Fab Fragment (HPAB-0355-CN-F(E)) | WB, ELISA, FC | Mouse Fab |
HPAB-0356-CN-F(E) | Mouse Anti-CA9 Recombinant Antibody; Fab Fragment (HPAB-0356-CN-F(E)) | WB, ELISA, FC | Mouse Fab |
HPAB-0357-CN-F(E) | Mouse Anti-CA9 Recombinant Antibody; Fab Fragment (HPAB-0357-CN-F(E)) | WB, ELISA, FC | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-H43 | Afuco™ Anti-CA9 ADCC Recombinant Antibody (Girentuximab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
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