Anti-CEACAM5-Phy-lys-SN-38 ADC (CAT#: ADC-015LZY)

• Antibody Overview
• Humanized Anti-CD66e IgG1

• Antibody Isotype
• IgG1

• Linker
• Phy-lys (Phenylalanine-lysine)

• Linker Class/Description
• Class: Enzymatically cleavable linker-Peptide linker
  Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.

• Drug
• SN-38(7-ethyl-10-hydroxy camptothecin)

• Drug Class/Description
• Class: SN-38
  Description: SN38 (7-ethyl-10-hydroxy camptothecin) is an active metabolite of the cancer prodrug, irinotecan, with the ability of inhibiting Topoisomerase I, which is belong to the camptothecin family. SN-38 is formed via hydrolysis of irinotecan by carboxylesterases and metabolized via glucuronidation by UGT1A1

• Introduction
• Members of the CEACAM subfamily, including CEACAM5, belong to the CEA gene family. For general information on the CEA gene family, see CEACAM1 (MIM 109770).[supplied by OMIM, Oct 2009]

• Alternative Names
• CEACAM5; carcinoembryonic antigen-related cell adhesion molecule 5; CEA; CD66e; meconium antigen 100;

• Gene ID
• 1048

• UniProt ID
• A0A024R0K5

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