Afuco™ Anti-CD27 ADCC Recombinant Antibody (Varlilumab), ADCC Enhanced (CAT#: AFC-TAB-H74)
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant human antibody to Human CD27. Varlilumab is an immunotherapy designed to enhance the body's natural immune response by directly activating T cells that can specifically recognize and kill cancer cells.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Lymph node
(Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2420/6097_A_8_8.jpg
(Germinal center cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2420/6097_A_8_8.jpg
Figure 2 Tonsil
(Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2420/6097_A_5_8.jpg
(Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2420/6097_A_5_8.jpg
Figure 3 High expression in lymph node.
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2420/6097_A_7_8_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2420/6097_A_7_8_val_selected.jpg
Figure 4 Lymph node
(Germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2420/6097_A_8_8.jpg
(Germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2420/6097_A_8_8.jpg
Figure 5 Tonsil
(Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2420/6097_A_5_8.jpg
(Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2420/6097_A_5_8.jpg
Figure 6 RNA cell line category: Group enriched (Daudi, U-698)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000139193-CD27
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000139193-CD27
Figure 3 RNA cell line category: Group enriched (Daudi, U-698)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000139193-CD27
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000139193-CD27
Specifications
- Host Species
- Human
- Derivation
- human
- Type
- ADCC enhanced antibody
- Specificity
- CD27 (TNFRSF7, tumor necrosis factor receptor superfamily member 7) [Homo sapiens]
- Species Reactivity
- Human
- Clone
- Varlilumab
- Applications
- ELISA, IP, FC, FuncS, Neut, IF
- Conjugate
- Unconjugated
- Generic Name
- Varlilumab
- Related Disease
- Solid tumors
Product Property
- Purity
- >95% by SDS-PAGE
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Varlilumab; CD27; CD27 molecule; TNFRSF7, tumor necrosis factor receptor superfamily, member 7; CD27 antigen; S152; Tp55; CD27L receptor; T cell activation antigen S152; T-cell activation antigen CD27; tumor necrosis factor receptor superfamily, member 7; T14;
- Gene ID
- 939
- UniProt ID
- P26842
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "varlilumab"
Anti-Human CD27 Recombinant Antibody (Varlilumab)Recombinant human antibody to Human CD27. Varlilumab is an immunotherapy designed to enhance the body's natural immune response by directly activating T cells that can specifically recognize and kill cancer cells.
See other products for "Clone varlilumab"
See other products for "CD27"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2370z | Mouse Anti-CD27 Recombinant Antibody (clone 16G8) | WB, ELISA, IF, IHC | Mouse IgG1 |
| FN-229CQ | Hamster Anti-CD27 Recombinant Antibody (clone LG.3A10) | FC, FuncS, IHC-Fr | Armenian hamster IgG |
| ZG-1041F | Armenian Hamster Anti-CD27 Antibody (clone LG.8A6) | ELISA, FC, IP | Armenian Hamster IgG |
| ZG-0027U | Rabbit Anti-CD27 Recombinant Antibody (clone 4A1) | ELISA, WB | Rabbit IgG |
| VS-0723-WK285 | Rabbit Anti-CD27 Recombinant Antibody (VS-0723-WK285) | ELISA, FC | Rabbit IgG |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H74 | Anti-Human CD27 Recombinant Antibody (Varlilumab) | ELISA, IP, FC, FuncS, Neut, IF, ICC | IgG1 - kappa |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-022LC | Human Anti-CD27 Recombinant Antibody (TAB-022LC) | ELISA | Humanized antibody |
| TAB-023LC | Human Anti-CD27 Recombinant Antibody (TAB-023LC) | ELISA | Humanized antibody |
| TAB-024LC | Human Anti-CD27 Recombinant Antibody (TAB-024LC) | ELISA, CDC, SPR | Humanized antibody |
| TAB-025LC | Human Anti-CD27 Recombinant Antibody (TAB-025LC) | ELISA, FC, CDC, ADCC, SPR | Humanized antibody |
| TAB-022LC-F(E) | Human Anti-CD27 Recombinant Antibody; Fab Fragment (TAB-022LC-F(E)) | ELISA | Humanized Fab |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-026LC | Anti-Human CD27 Recombinant Antibody (2F2) | SPR, FC | |
| TAB-027LC | Anti-Human CD27 Recombinant Antibody (5F2) | SPR, FC | |
| TAB-028LC | Anti-Human CD27 Recombinant Antibody (5F32) | SPR, FC | |
| TAB-029LC | Anti-Human CD27 Recombinant Antibody (11F26) | SPR, FC | |
| TAB-030LC | Anti-Human CD27 Recombinant Antibody (10F13) | SPR, FC |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-039LC-F(E) | Anti-Human CD27 Recombinant Antibody Fab Fragment (0154) | SPR, FC | Chimeric antibody (rabbit/human) |
| TAB-040LC-F(E) | Anti-Human CD27 Recombinant Antibody Fab Fragment (0155) | SPR, FC | Chimeric antibody (rabbit/human) |
| TAB-041LC-F(E) | Anti-Human CD27 Recombinant Antibody Fab Fragment (5F24) | SPR, FC | Chimeric antibody (mouse/human) |
| TAB-042LC-F(E) | Chimeric Anti-Human CD27 Recombinant Antibody Fab Fragment (5F32) | SPR, FC | Chimeric antibody (mouse/human) |
| TAB-043LC-F(E) | Chimeric Anti-Human CD27 Recombinant Antibody Fab Fragment (10F13) | SPR, FC | Chimeric antibody (mouse/human) |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-320CQ | Hamster Anti-CD27 Recombinant Antibody (clone LG.7F9) | FC, FuncS, Neut | Hamster IgG |
| NEUT-321CQ | Mouse Anti-CD27 Recombinant Antibody (clone MM0165-7H21) | WB, Neut, FC | Mouse IgG1 |
| NEUT-322CQ | Mouse Anti-CD27 Recombinant Antibody (clone CBL803) | WB, FC, CyTOF, Neut | Mouse IgG1 |
| NEUT-323CQ | Mouse Anti-CD27 Recombinant Antibody (clone CBL185) | FC, Neut, WB | Mouse IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0547 | Hi-Affi™ Rabbit Anti-CD27 Recombinant Antibody (clone DS547AB) | WB, IHC, ICC, FC | Rabbit IgG |
Agonistic Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-096LC | Human Anti-CD27 Recombinant Antibody (MOB-096LC) | ELISA, FuncS, WB | Human IgG1, κ |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0299-CN-S(P) | Human Anti-CD27 Recombinant Antibody; scFv Fragment (HPAB-0299-CN-S(P)) | ELISA, FC, Block | Human scFv |
| HPAB-0300-CN-S(P) | Human Anti-CD27 Recombinant Antibody; scFv Fragment (HPAB-0300-CN-S(P)) | ELISA, FC, Block | Human scFv |
| HPAB-N0032-YC-S(P) | Human Anti-CD27 Recombinant Antibody; scFv Fragment (HPAB-N0032-YC-S(P)) | ELISA, FC | Human scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0299-CN-F(E) | Human Anti-CD27 Recombinant Antibody; Fab Fragment (HPAB-0299-CN-F(E)) | ELISA, FC, Block | Human Fab |
| HPAB-0300-CN-F(E) | Human Anti-CD27 Recombinant Antibody; Fab Fragment (HPAB-0300-CN-F(E)) | ELISA, FC, Block | Human Fab |
| HPAB-N0032-YC-F(E) | Human Anti-CD27 Recombinant Antibody; Fab Fragment (HPAB-N0032-YC-F(E)) | ELISA, FC | Human Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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