Rabbit Anti-CD46 Recombinant Antibody (clone R06-3I6) (CAT#: VS3-XY3298)

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human CD46

• Species Reactivity
• Human

• Clone
• R06-3I6

• Applications
• WB, IHC-P, ICC, IF

• Related Disease
• Hemolytic uremic syndrome, atypical, 2 (AHUS2)

• Clonality
• Monoclonal

• Aggregation
• < 5%

• Format
• Liquid

• Buffer
• PBS (pH 7.4), 150 mM NaCl and 50% glycerol

• Preservative
• 0.02% sodium azide

• Storage
• Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• WB: 1/500-1/1000
  IHC: 1/50-1/100
  IF: 1/50-1/200

• Alternative Names
• MCP; TLX; AHUS2; MIC10; TRA2.10

• Gene ID
• 4179

• UniProt ID
• P15529

• Long Name
• CD46 molecule

• Cellular Localization
• Cytoplasmic vesicle, Membrane

• Post Translation Modifications
• N-glycosylated on Asn-83; Asn-114 and Asn-273 in most tissues, but probably less N-glycosylated in testis. N-glycosylation on Asn-114 and Asn-273 is required for cytoprotective function. N-glycosylation on Asn-114 is required for Measles virus binding. N-glycosylation on Asn-273 is required for Neisseria binding. N-glycosylation is not required for human adenovirus binding.

• Protein Refseq
• XP_047276844.1; XP_011507865.1

• Function
• Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells.

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Recommended Dilution Buffer

• MRO-0253YJ
• Reconstitution Buffer PBS

Secondary Antibody

• 2RD-A1473-YJ
• Goat Anti-Rabbit IgG-F(ab')2 Secondary antibody

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