Rabbit Anti-CD46 Recombinant Antibody (VS13-YC166) (CAT#: VS13-YC166)
The Rabbit Anti-CD46 Recombinant Antibody is specific for human and rat CD46. CD46, with roles in complement pathways, influences conditions like hemolytic uremic syndrome through receptor-mediated actions impacting immunity and coagulation. The anti-CD46 antibody can be used for Western blot (1/1000-1/5000), Immunocytochemistry (1/50-1/200), Immunohistochemistry-paraffin (1/50-1/800).
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10401/if_selected.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10401/if_selected.jpg
Figure 2 IHC staining of human placenta
(Immunohistochemical staining of human placenta shows strong membranous positivity in trophoblastic cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10401/ihc_selected.jpg
(Immunohistochemical staining of human placenta shows strong membranous positivity in trophoblastic cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10401/ihc_selected.jpg
Figure 3 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10401/211_E5_1_blue_red_green.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10401/211_E5_1_blue_red_green.jpg
Figure 4 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10401/209_E5_1_blue_red_green.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10401/209_E5_1_blue_red_green.jpg
Figure 5 Colon
(Glandular cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16903/38899_A_9_3.jpg
(Glandular cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16903/38899_A_9_3.jpg
Figure 6 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000117335-CD46
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000117335-CD46
Figure 6 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000117335-CD46
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000117335-CD46
Specifications
- Immunogen
- Recombinant human CD46, aa 31-80.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Rat CD46
- Species Reactivity
- Human, Rat
- Applications
- WB, ICC, IF, IHC-P
- Conjugate
- NONE
- Related Disease
- Hemolytic Uremic Syndrome, Atypical and Measles
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- TBS (pH 7.4) containing 40% Glycerol and 0.05% BSA.
- Preservative
- 0.05% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Western blot (WB): 1/1000-1/5000
Immunocytochemistry (ICC): 1/50-1/200
Immunohistochemistry-paraffin (IHC-P): 1/50-1/800
Target
- Alternative Names
- CD46 Molecule; Membrane Cofactor Protein (CD46, Trophoblast-Lymphocyte Cross-Reactive Antigen); Antigen Identified By Monoclonal Antibody TRA-2-10; CD46 Molecule, Complement Regulatory Protein; CD46 Antigen, Complement Regulatory Protein; Trophoblast Leukocyte Common Antigen; MIC10; MCP; TLX;
- Gene ID
- 4179
- UniProt ID
- P15529
- Long Name
- CD46 Molecule
- Cellular Localization
- Cytoplasmic vesicle; Cell membrane
- Protein Refseq
- XP_047276844.1; XP_011507865.1
- Function
- Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0288CL | Human Anti-CD46 Recombinant Antibody (TAB-0288CL) | RIA, ELISA, FC | Human IgG1 |
| TAB-0289CL | Human Anti-CD46 Recombinant Antibody (TAB-0289CL) | RIA, ELISA, FC | Human IgG1 |
| TAB-0290CL | Human Anti-CD46 Recombinant Antibody (TAB-0290CL) | RIA, ELISA, FC | Human IgG1 |
| TAB-0291CL | Human Anti-CD46 Recombinant Antibody (TAB-0291CL) | RIA, ELISA, FC | Human IgG1 |
| TAB-0292CL | Human Anti-CD46 Recombinant Antibody (TAB-0292CL) | RIA, ELISA, FC | Human IgG1 |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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