Rabbit Anti-CD46 Recombinant Antibody (VS13-YC166)
CAT#: VS13-YC166
The Rabbit Anti-CD46 Recombinant Antibody is specific for human and rat CD46. CD46, with roles in complement pathways, influences conditions like hemolytic uremic syndrome through receptor-mediated actions impacting immunity and coagulation. The anti-CD46 antibody can be used for Western blot (1/1000-1/5000), Immunocytochemistry (1/50-1/200), Immunohistochemistry-paraffin (1/50-1/800).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10401/if_selected.jpg
Subcellular Location
Figure 2 IHC staining of human placenta
Immunohistochemical staining of human placenta shows strong membranous positivity in trophoblastic cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10401/ihc_selected.jpg
Subcellular Location
Figure 3 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10401/211_E5_1_blue_red_green.jpg
Subcellular Location
Figure 4 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10401/209_E5_1_blue_red_green.jpg
Normal Tissue
Figure 5 Colon
Glandular cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16903/38899_A_9_3.jpg
RNA Expression
Figure 6 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000117335-CD46
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Specifications
- Immunogen
- Recombinant human CD46, aa 31-80.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Rat CD46
- Species Reactivity
- Human, Rat
- Applications
- WB, ICC, IF, IHC-P
- Conjugate
- NONE
- Related Disease
- Hemolytic Uremic Syndrome, Atypical and Measles
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- TBS (pH 7.4) containing 40% Glycerol and 0.05% BSA.
- Preservative
- 0.05% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Western blot (WB): 1/1000-1/5000
Immunocytochemistry (ICC): 1/50-1/200
Immunohistochemistry-paraffin (IHC-P): 1/50-1/800
Target
- Alternative Names
- CD46 Molecule; Membrane Cofactor Protein (CD46, Trophoblast-Lymphocyte Cross-Reactive Antigen); Antigen Identified By Monoclonal Antibody TRA-2-10; CD46 Molecule, Complement Regulatory Protein; CD46 Antigen, Complement Regulatory Protein; Trophoblast Leukocyte Common Antigen; MIC10; MCP; TLX;
- Gene ID
- 4179
- UniProt ID
- P15529
- Long Name
- CD46 Molecule
- Cellular Localization
- Cytoplasmic vesicle; Cell membrane
- Protein Refseq
- XP_047276844.1; XP_011507865.1
- Function
- Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "CD46"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0288CL | Human Anti-CD46 Recombinant Antibody (TAB-0288CL) | RIA, ELISA, FC | Human IgG1 |
| TAB-0289CL | Human Anti-CD46 Recombinant Antibody (TAB-0289CL) | RIA, ELISA, FC | Human IgG1 |
| TAB-0290CL | Human Anti-CD46 Recombinant Antibody (TAB-0290CL) | RIA, ELISA, FC | Human IgG1 |
| TAB-0291CL | Human Anti-CD46 Recombinant Antibody (TAB-0291CL) | RIA, ELISA, FC | Human IgG1 |
| TAB-0292CL | Human Anti-CD46 Recombinant Antibody (TAB-0292CL) | RIA, ELISA, FC | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-270LC | Human Anti-CD46 Recombinant Antibody (TAB-270LC) | Cyt, FuncS | Humanized IgG1, κ |
| TAB-270LC-S(P) | Human Anti-CD46 Recombinant Antibody; scFv Fragment (TAB-270LC-S(P)) | FC, ELISA | Humanized scFv |
| TAB-271LC-S(P) | Human Anti-CD46 Recombinant Antibody; scFv Fragment (TAB-271LC-S(P)) | FC, ELISA | Humanized scFv |
| TAB-270LC-F(E) | Human Anti-CD46 Recombinant Antibody; Fab Fragment (TAB-270LC-F(E)) | FC, ELISA | Humanized Fab |
| TAB-271LC-F(E) | Human Anti-CD46 Recombinant Antibody; Fab Fragment (TAB-271LC-F(E)) | FC, ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-268LC-S(P) | Mouse Anti-CD46 Recombinant Antibody; scFv Fragment (TAB-268LC-S(P)) | FC, ELISA | Mouse scFv |
| TAB-269LC-S(P) | Mouse Anti-CD46 Recombinant Antibody; scFv Fragment (TAB-269LC-S(P)) | FC, ELISA | Mouse scFv |
| TAB-268LC-F(E) | Mouse Anti-CD46 Recombinant Antibody; Fab Fragment (TAB-268LC-F(E)) | FC, ELISA | Mouse Fab |
| TAB-269LC-F(E) | Mouse Anti-CD46 Recombinant Antibody; Fab Fragment (TAB-269LC-F(E)) | FC, ELISA | Mouse Fab |
| TAB-272LC-F(E) | Anti-Human CD46 Recombinant Antibody Fab Fragment (mPA7) | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-385CQ | Mouse Anti-CD46 Recombinant Antibody (NEUT-385CQ) | FC, Block, IF, IP | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0564 | Hi-Affi™ Rabbit Anti-CD46 Recombinant Antibody (clone DS564AB) | ICC, IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0524-CN | Human Anti-CD46 Recombinant Antibody (HPAB-0524-CN) | WB, ELISA, FC, IHC, IP | Human IgG1 |
| HPAB-0525-CN | Human Anti-CD46 Recombinant Antibody (HPAB-0525-CN) | WB, ELISA, FC, IHC, IP | Human IgG1 |
| HPAB-0367-YC | Mouse Anti-CD46 Recombinant Antibody (clone SC1.N122) | ELISA, FC | Mouse IgG |
| HPAB-0368-YC | Mouse Anti-CD46 Recombinant Antibody (HPAB-0368-YC) | ELISA, FC | Mouse IgG |
| MRO-0308-CN | Rabbit Anti-CD46 Recombinant Antibody (clone JB25-49) | WB, IF, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0524-CN-S(P) | Human Anti-CD46 Recombinant Antibody; scFv Fragment (HPAB-0524-CN-S(P)) | WB, ELISA, FC, IHC, IP | Human scFv |
| HPAB-0525-CN-S(P) | Human Anti-CD46 Recombinant Antibody; scFv Fragment (HPAB-0525-CN-S(P)) | WB, ELISA, FC, IHC, IP | Human scFv |
| HPAB-0366-YC-S(P) | Human Anti-CD46 Recombinant Antibody; scFv Fragment (HPAB-0366-YC-S(P)) | ELISA, FC | Humanized scFv |
| HPAB-0368-YC-S(P) | Mouse Anti-CD46 Recombinant Antibody; scFv Fragment (HPAB-0368-YC-S(P)) | ELISA, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0524-CN-F(E) | Human Anti-CD46 Recombinant Antibody; Fab Fragment (HPAB-0524-CN-F(E)) | WB, ELISA, FC, IHC, IP | Human Fab |
| HPAB-0525-CN-F(E) | Human Anti-CD46 Recombinant Antibody; Fab Fragment (HPAB-0525-CN-F(E)) | WB, ELISA, FC, IHC, IP | Human Fab |
| HPAB-0367-YC-F(E) | Mouse Anti-CD46 Recombinant Antibody (clone SC1.N122); Fab Fragment | ELISA, FC | Mouse Fab |
| HPAB-0368-YC-F(E) | Mouse Anti-CD46 Recombinant Antibody; Fab Fragment (HPAB-0368-YC-F(E)) | ELISA, FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY54 | AbPlus™ Anti-CD46 Magnetic Beads (VS-0424-XY54) | IP, Protein Purification | |
| VS-0724-YC422 | AbPlus™ Anti-CD46 Magnetic Beads (VS-0724-YC422) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY113 | Mouse Anti-CD46 (clone mPA7) scFv-Fc Chimera | Inhib, WB | Mouse IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY367 | Anti-CD46 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1189 | Anti-Rat CD46 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1190 | Anti-Mouse CD46 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1188 | Anti-Human CD46 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC188 | Recombinant Anti-CD46 Vesicular Antibody, EV Displayed (VS-0425-YC188) | ELISA, FC, Cell-uptake |
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