Recombinant Anti-COL2A1 Eliminating Antibody, pH-Sensitive (VS-0625-YC67)
CAT#: VS-0625-YC67
The anti-COL2A1 eliminating antibody is an engineered pH-sensitive antibody against human and rat COL2A1. COL2A1, a type II collagen, is linked to cartilage disorders and osteoarthritis. The antibody has a novel COL2A1-sweeping activity in vivo, which selectively eliminatesthe soluble COL2A1 from plasma. Compared to conventional antibody, the mAb exerted in vivo efficacy by simultaneously engineering both pH-dependent antigen binding, to mimic the pH-dependent receptor-ligand binding of such endocytic receptors, and increased FcRn binding affinity at neutral pH, to mimic the cell-bound form of the receptors.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HEK 293
Immunofluorescent staining of human cell line HEK 293 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/55753/1472_C7_4_selected.jpg
Normal Tissue
Figure 2 IHC staining of human cartilage
Immunohistochemical staining of human cartilage shows moderate cytoplasmic positivity in the chondrocytes.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/ih_additional_tissue/2214/1552_866_400x400.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuronal cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2214/169753_B_7_5.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (AF22, HAP1, HEK93)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000139219-COL2A1
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Specifications
- Host Species
- Human
- Type
- Human IgG
- Specificity
- Human and Rat COL2A1
- Species Reactivity
- Human, Rat
- Applications
- Antigen-Sweeping In Vivo.
Product Property
- Purification
- Protein A/G purified
- Purity
- >95%
- Format
- Liquid
- Buffer
- PBS only
- Preservative
- None
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "COL2A1"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-225 | Recombinant Human Anti-human COL2A1 Antibody | WB, FC, FuncS | IgG |
| VS3-QX258 | Mouse Anti-COL2A1 Recombinant Antibody (clone 5F4-4D3-9A6) | IHC | Mouse IgG1 |
| VS3-QX259 | Mouse Anti-COL2A1 Recombinant Antibody (clone 9C3-9H6-2G7) | IHC | Mouse IgG1 |
| VS3-QX260 | Mouse Anti-COL2A1 Recombinant Antibody (clone 9D5-9F3-8H1) | IHC | Mouse IgG1 |
| VS3-QX261 | Mouse Anti-COL2A1 Recombinant Antibody (clone 9E1-6F10-8F1) | IHC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-225-F(E) | Recombinant Human Anti-human COL2A1 Antibody Fab Fragment | ELISA, IP, FuncS | Fab |
| PFBZ-088 | Mouse Anti-COL2A1 Recombinant Antibody (clone ACC4); Fab Fragment | ELISA, IP, IHC | Mouse Fab |
| PFBL-644 | Mouse Anti-COL2A1 Recombinant Antibody (clone M2139); Fab Fragment | ELISA | Mouse Fab |
| HPAB-0281-YC-F(E) | Human Anti-COL2A1 Recombinant Antibody; Fab Fragment (HPAB-0281-YC-F(E)) | ELISA, IHC, FuncS | Human Fab |
| PFBC-248 | Mouse Anti-COL2A1 Recombinant Antibody (clone ACC1); Fab Fragment | ELISA, IHC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-225-S(P) | Recombinant Human Anti-human COL2A1 Antibody scFv Fragment | WB, IP, FuncS | scFv |
| PSBZ-088 | Mouse Anti-COL2A1 Recombinant Antibody (clone ACC4); scFv Fragment | ELISA, IP, IHC | Mouse scFv |
| PSBL-644 | Mouse Anti-COL2A1 Recombinant Antibody (clone M2139); scFv Fragment | ELISA | Mouse scFv |
| HPAB-0281-YC-S(P) | Human Anti-COL2A1 Recombinant Antibody; scFv Fragment (HPAB-0281-YC-S(P)) | ELISA, IHC, FuncS | Human scFv |
| PSBC-248 | Mouse Anti-COL2A1 Recombinant Antibody (clone ACC1); scFv Fragment | ELISA, IHC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY501 | Anti-COL2A1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1587 | Anti-Mouse COL2A1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1588 | Anti-Human COL2A1 Immunohistochemistry Kit | IHC |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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