Anti-COL2A1 Recombinant Antibody Products

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Anti-COL2A1 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is leading the way in rheumatology and orthopedic research by providing top-quality anti-COL2A1 recombinant antibodies. Collagen Type II (COL2A1), the exclusive collagen found in hyaline cartilage, is the major structural protein of joints. Our high-quality antibodies will be your research’s best partners as you study the pathology of osteoarthritis, rheumatoid arthritis, and the development of congenital chondrodysplasias.

COL2A1: The Key Structural Protein of Cartilage

Collagen Type II Alpha 1 (COL2A1) is the major component of articular cartilage that provides its tensile strength and elasticity. As a fine fibrillar network that traps proteoglycans in the cartilage extracellular matrix, COL2A1 allows cartilage to resist extreme compressive force. The pathology of most joint diseases is centered around this protein. In osteoarthritis, COL2A1 is proteolytically broken down, leading to cartilage loss. In some cases of rheumatoid arthritis, one’s own immune system is trained to see COL2A1 as foreign, leading to an autoimmune attack that destroys the joint.

Alternative Names

Collagen Type II Alpha 1 Chain; Arthroophthalmopathy, Progressive (Stickler Syndrome); Collagen, Type II, Alpha 1; Alpha-1 Type II Collagen; Collagen, Type II, Alpha 1 (Primary Osteoarthritis, Spondyloepiphyseal Dysplasia, Congenital); Collagen II, Alpha-1 Polypeptide; Collagen Alpha-1(II) Chain; Collagen Type II Alpha 1

Background

This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia. There are two transcripts identified for this gene.

Anti-COL2A1 rAb Products

Creative Biolabs’ recombinant antibodies to COL2A1 have been engineered to have high affinity and specificity. Our antibodies are extensively validated to specifically detect Type II collagen without cross-reacting with the more abundant Type I collagen. Accurate and specific study of cartilage requires an antibody that can exclusively recognize this important protein. We have optimized our rAbs for IHC on joint sections and for ELISAs that will allow you to quantify collagen fragments in synovial fluid. Creative Biolabs rAbs are a premier choice for arthritis research.

Table 1. Featured anti-COL2A1 recombinant antibody products at Creative Biolabs.

Customer Reviews

Excellent

B**ce
Human Anti-COL2A1 Recombinant Antibody (HPAB-0281-YC)

I love the quality of Creative Biolabs antibodies. We have used their anti-COL2A1 antibody as a major tool in our lab to study the basic biology of chondrocytes.

22/Jan/2022

rAb Production

Creative Biolabs is committed to fast-tracking the discoveries that improve rheumatology outcomes with next-generation antibody production platforms. Our anti-COL2A1 recombinant antibodies are produced in optimized expression systems to promote proper folding and recognition of the native protein, ensuring maximum functional activity in your research applications.

Featured Anti-COL2A1 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-COL2A1 recombinant antibody production.

Fig.2 Gram-scale anti-COL2A1 recombinant antibody production.

rAb Modalities

Creative Biolabs is here to support your arthritis research with versatile and innovative solutions. Our anti-COL2A1 recombinant antibodies are available in multiple customizable modalities to meet your research needs, including matched pairs of antibodies for biomarker assays, so that researchers worldwide can study this important structural protein.

Fig.3 Full-length anti-COL2A1 recombinant antibody production and modalities.

Creative Biolabs recombinant antibodies will help you see the mechanisms of cartilage degradation with absolute clarity. We are driven by high standards of validation and specificity that define our portfolio, offering you the best tools to study joint health and disease. We are quality that moves science forward. Let’s talk today.