Mouse Anti-COL2A1 Recombinant Antibody (clone ACC4) (CAT#: PABZ-088)
Recombinant Mouse Antibody (ACC4) is capable of binding to Mouse Col2a1, expressed in Chinese Hamster Ovary cells (CHO).
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Figure 2 Enforced sialylation reduces the arthritogenic activity of ACPAs.
(a) An experimental scheme for enforced sialylation. (b) LC-ESI-MS analysis of ACC4 and M2139 was performed to detect desialylated glycoforms (G0F, G1F and G2F) and sialylated glycoforms (G1FS1, G2FS1 and G2FS2) of IgG Fc glycans. To normalize the variability, summation of peak areas of all complex type N-glycans were deliberately set at 100%. (c) Antigen-binding ability of Sia (+) and control ACC4/M2139 was compared by ELISA. (d) An experimental scheme for CAIA. (e) Frequency (upper panel) and score (lower panel) of arthritis is plotted. Data for arthritis scores are shown as mean±s.d. (n=13 for ACC4/M2139 and n=10 for ACC4/M2139 Sia (+)). The data are representative of two independent experiments. (f) Histological analysis of joint inflammation at day 14 post-LPS injection. Paraffin sections of the limb were stained by HE (upper panel) and Safranin O/Fast green for cartilage (red) staining (lower panel). Scale bar, 60 μm.
Ohmi, Y., Ise, W., Harazono, A., Takakura, D., Fukuyama, H., Baba, Y., ... & Ji, S. (2016). Sialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis. Nature communications, 7, 11205.
Specifications
- Immunogen
- Mouse collagen, type II, alpha 1
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Mouse COL2A1
- Species Reactivity
- Mouse
- Clone
- ACC4
- Applications
- ELISA, IP, IHC
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The antibody ACC4 has been reported in applications of Enzyme-linked Immunosorbent Assay, Immunohistochemistry, Immunoprecipitation. It's recommended that the optimal antibody concentration, dilution, incubition time etc. are best to be carefully titrated in specific assays.
Enzyme-linked Immunosorbent Assay: A reported concentration of the antibody ACC4 for Enzyme-linked Immunosorbent Assay was 8-1000 ng/mL.
Target
- Alternative Names
- COL2A1; collagen, type II, alpha 1; Dmm; Lpk; Col2; Del1; Col2a; Col2a-1; M100856; Rgsc856; collagen alpha-1(II) chain; chondrocalcin; alpha-1 type II collagen; disproportionate micromelia; procollagen, type II, alpha 1
- Gene ID
- 12824
- UniProt ID
- P28481
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-225-F(E) | Recombinant Anti-human COL2A1 Antibody Fab Fragment | FC, WB, FuncS | Fab |
| MHH-225-F(E) | Recombinant Human Anti-human COL2A1 Antibody Fab Fragment | ELISA, IP, FuncS | Fab |
| PFBZ-088 | Mouse Anti-COL2A1 Recombinant Antibody (clone ACC4); Fab Fragment | ELISA, IP, IHC | Mouse Fab |
| PFBL-644 | Mouse Anti-COL2A1 Recombinant Antibody (clone M2139); Fab Fragment | ELISA | Mouse Fab |
| PFBC-248 | Mouse Anti-COL2A1 Recombinant Antibody (clone ACC1); Fab Fragment | ELISA, IHC | Mouse Fab |
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