Recombinant Anti-F8 (A2 domain x C1 domain) Biparatopic Antibody, Tandem scFv (Clone JM4 x Clone KM33)
CAT#: VS-0525-YC76
The Recombinant Anti-F8 (A2 domain x C1 domain) Biparatopic Antibody, Tandem scFv (Clone JM4 x Clone KM33) functions as a biparatopic antibody (bpAb), binding two unique epitopes on Factor VIII (F8). Its tandem scFv format combines the JM4 scFv (targeting the A2 domain of FVIII) with an N-terminal fusion to the KM33 scFv (recognizing the C1 domain of FVIII).
Gene Expression
Normal Tissue
Figure 1 Colon
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18777/41664_A_7_3.jpg
Normal Tissue
Figure 2 Kidney
Cells in glomeruli
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Cells in tubules
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18777/41664_A_7_5.jpg
Normal Tissue
Figure 3 Testis
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18777/41664_A_4_6.jpg
RNA Expression
Figure 4 RNA cell line category:Cell line enhanced (U-2197)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000185010-F8
❮
❯
Specifications
- Host Animal 1
- Human
- Host Animal 2
- Human
- Specificity
- Human factor VIII
- Species Reactivity
- Human
- Type
- Tandem scFv
- Valency
- 1 + 1
- Clone 1
- JM4
- Clone 2
- KM33
- Epitope 1
- A2 domain of FVIII
- Epitope 2
- C1 domain of FVIII
- Purity
- >90%
- Purification
- Affinity purified
- Applications
- ELISA
- Concentration
- Lot specific
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid freeze-thaw cycles.
- Long Name
- Coagulation Factor VIII
Target
- Introduction
- This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor x to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.
- Alternative Names
- AHF; F8B; F8C; HEMA; FVIII; DXS1253E
- Gene ID
- 2157
- UniProt ID
- P00451
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Datasheet
MSDS
COA
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| FAMAB-0039JF-F(E) | Human Anti-F8 Recombinant Antibody (clone JM4); Fab Fragment | IP, ELISA, FuncS | Human Fab |
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