DRB1*11:01/Factor VIII Factor VIII (ENIQRFLPNPAGVQLEDPEF) MHC Monomer
CAT#: MHC-YF075
This product is a MHC monomer of biotinylated peptide/MHC complex composed Factor VIII-derived peptide of ENIQRFLPNPAGVQLEDPEF sequence covering 589–608 and DRB1*11:01 molecule. The pMHC monomer recognizes human CD8 T cells and can be used in the MHC tetramer analysis of individual antigen-specific T cells.
Gene Expression
Normal Tissue
Figure 1 Colon
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18777/41664_A_7_3.jpg
Normal Tissue
Figure 2 Kidney
Cells in glomeruli
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Cells in tubules
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18777/41664_A_7_5.jpg
Normal Tissue
Figure 3 Testis
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18777/41664_A_4_6.jpg
RNA Expression
Figure 4 RNA cell line category:Cell line enhanced (U-2197)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000185010-F8
❮
❯
Specifications
- Allele
- DRB1*11:01
- Class
- Class II
- MHC Species
- Human
- Antigen
- Factor VIII
- Antigen Species
- Factor VIII
- Peptide
- ENIQRFLPNPAGVQLEDPEF
- Range
- 589–608
- Conjugate
- Biotin
- Application
- MHC Multimer
Target
- Antigen Introduction
- This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.
- Alternative Names
- AHF; F8B; F8C; HEMA; FVIII; DXS1253E
- Gene ID
- 2157
- UniProt ID
- P00451
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Datasheet
MSDS
COA
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