Recombinant Mouse Antibody (3E6) is capable of binding to Coagulation factor VIII, expressed in Chinese Hamster Ovary cells (CHO).
Figure 1 ELISA of C2-mAb interactions.
Binding of His6-C2 to immobilized 3E6 IgG (●) and G99 IgG (○). Bound His6-C2 was detected using the Ni-NTA-alkaline phosphatase/pNPP system.
Walter, J. D., Werther, R. A., Polozova, M. S., Pohlman, J., Healey, J. F., Meeks, S. L., ... & Spiegel, P. C. (2013). Characterization and solution structure of the factor VIII C2 domain in a ternary complex with classical and non-classical inhibitor antibodies. Journal of Biological Chemistry, 288(14), 9905-9914.
Figure 2 Bethesda assays for inhibition of fVIII activity in plasma.
Pooled normal human plasma was successively diluted with IgG or Fab, and one-stage coagulation activity was measured. Inhibition of fVIII activity by 3E6 whole IgG (○) and 3E6 Fab (●).
Walter, J. D., Werther, R. A., Polozova, M. S., Pohlman, J., Healey, J. F., Meeks, S. L., ... & Spiegel, P. C. (2013). Characterization and solution structure of the factor VIII C2 domain in a ternary complex with classical and non-classical inhibitor antibodies. Journal of Biological Chemistry, 288(14), 9905-9914.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
NAB-930-VHH | Recombinant Anti-Human F8 VHH Single Domain Antibody | ELISA, Neut, ICC, FC | Llama VHH |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-259CL | Human Anti-F8 Recombinant Antibody (TAB-259CL) | ELISA | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBL-051 | Mouse Anti-F8 Recombinant Antibody (clone 3E6); Fab Fragment | ELISA, WB, FuncS | Mouse Fab |
PFBL-052 | Mouse Anti-F8 Recombinant Antibody (clone G99); Fab Fragment | ELISA, WB, FuncS | Mouse Fab |
HPAB-0096-YC-F(E) | Human Anti-F8 Recombinant Antibody (clone YK3.3.38); Fab Fragment | ELISA, FuncS | Human Fab |
HPAB-0178CQ-F(E) | Mouse Anti-F8 Recombinant Antibody; Fab Fragment (HPAB-0178CQ-F(E)) | ELISA, DB, Inhib | Mouse Fab |
HPAB-0793-FY-S(P) | Mouse Anti-F8 Recombinant Antibody (clone 4F143); Fab Fragment | Activ | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-016WM | Anti-Human F8 Recombinant Antibody (BOIIB2) | Inhib, ELISA | |
TAB-017WM | Anti-Human F8 Recombinant Antibody (4F50) | ELISA | |
TAB-016WM-S(P) | Anti-Human F8 Recombinant Antibody scFv Fragment (BOIIB2) | ELISA | |
TAB-016WM-F(E) | Anti-Human F8 Recombinant Antibody Fab Fragment (BOIIB2) | ELISA | |
TAB-017WM-F(E) | Anti-Human F8 Recombinant Antibody Fab Fragment (4F50) | ELISA |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-014LC | Recombinant Anti-Human F8 Antibody (Fab glycosylation) | ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-015LC | Recombinant Anti-Human F8 Antibody (Non-glycosylated) | ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
PABX-058 | Recombinant Human Anti-F8 Antibody (BO2C11) | WB, ELISA, FuncS, Inhib, PK, IP, SPR | IgG |
PABX-058-S (P) | Recombinant Human Anti-F8 Antibody scFv Fragment (BO2C11) | WB, ELISA, FuncS | scFv |
PABX-058-F (E) | Recombinant Human Anti-F8 Antibody Fab Fragment (BO2C11) | WB, ELISA, FuncS | Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-765CQ | Mouse Anti-F8 Recombinant Antibody (clone CBL215) | ELISA, WB, Neut | Mouse IgG2a |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-1229 | Hi-Affi™ Rabbit Anti-F8 Recombinant Antibody (clone DS1229AB) | ELISA | Rabbit IgG |
MOR-4166 | Hi-Affi™ Rabbit Anti-F8 Recombinant Antibody (clone SI243DS) | ELISA | Rabbit IgG |
MOR-4167 | Hi-Affi™ Rabbit Anti-F8 Recombinant Antibody (clone SI244DS) | ELISA | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
EPAF-0611LC | Human Anti-F8 Recombinant Antibody (clone BO2C11) | ELISA | Human IgG4 |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0178CQ-S(P) | Mouse Anti-F8 Recombinant Antibody; scFv Fragment (HPAB-0178CQ-S(P)) | ELISA, DB, Inhib | Mouse scFv |
FAMAB-0201JF-S(P) | Human Anti-F8 Recombinant Antibody (clone KM38); scFv Fragment | WB, ELISA, FuncS | Human scFv |
FAMAB-0286JF-S(P) | Human Anti-F8 Recombinant Antibody (clone VK34); scFv Fragment | ELISA, FuncS | Human scFv |
FAMAB-0287JF-S(P) | Human Anti-F8 Recombinant Antibody (clone VK41); scFv Fragment | ELISA, FuncS | Human scFv |
HPAB-1613WJ-S(P) | Human Anti-F8 Recombinant Antibody; scFv Fragment (clone KRIX 1) | ELISA, IP | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-1977-FY | Human Anti-F8 Recombinant Antibody (clone 92-137) | Inhib | Human IgG |
HPAB-1978-FY | Human Anti-F8 Recombinant Antibody (clone 92-102) | Inhib | Human IgG |
HPAB-1979-FY | Human Anti-F8 Recombinant Antibody (clone WR8) | IP | Human IgG4 |
HPAB-1980-FY | Human Anti-F8 Recombinant Antibody (clone WR11) | IP | Human IgG4 |
HPAB-1981-FY | Human Anti-F8 Recombinant Antibody (clone WR10) | IP | Human IgG4 |
CAT | Product Name | Application | Type |
---|---|---|---|
MHC-YF075 | DRB1*11:01/Factor VIII Factor VIII (ENIQRFLPNPAGVQLEDPEF) MHC Monomer | MHC Multimer |
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