Human Anti-F8 (clone BO2C11) scFv-Fc Chimera
CAT#: VS-0425-FY172
This antibody targets Factor VIII (F8), a crucial coagulation protein deficient in hemophilia A. An anti-F8 scFv-FC could be used for research into F8 function or potentially in novel therapeutic approaches for hemophilia A.
Gene Expression
Normal Tissue
Figure 1 Colon
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18777/41664_A_7_3.jpg
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human F8
- Species Reactivity
- Human
- Clone
- BO2C11
- Applications
- Inhibition, ELISA
- Related Disease
- Hemophilia A
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- BO2C11 antibody specifically recognizes the C2 domain and effectively inhibits the binding of factor VIII (FVIII) to von Willebrand factor (vWF) and phospholipids (PL).
The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Coagulation Factor VIII; Coagulation Factor VIII, Procoagulant Component; Antihemophilic Factor; F8C; AHF; Coagulation Factor VIII A1 Domain; Coagulation Factor VIII C2 Domain; Coagulation Factor VIIIc; Procoagulant Component
- Gene ID
- 2157
- UniProt ID
- P00451
- Long Name
- Coagulation Factor VIII
- Sequence Similarities
- Belongs to the multicopper oxidase family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- Sulfation on Tyr-1699 is essential for binding vWF.
Proteolytically cleaved by cathepsin CTSG to produce a partially activated form.
Glycosylation at Asn60, Asn258, Asn601, Asn776, Asn803, Asn847, Asn919, Asn962, Asn982, Asn1020, Asn1024, Asn1074, Asn1085, Asn1204, Asn1274, Asn1278, Asn1301, Asn1319, Asn1431, Asn1461, Asn1829, and Asn2137
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect FA8_HUMAN (99)
Glycosylation from GlyGen 27 sites, 59 N-linked glycans (15 sites), 2 O-linked glycans (3 sites)
- Protein Refseq
- NP_000123.1; NP_063916.1
- Function
- Factor VIII, along with calcium and phospholipid, acts as a cofactor for F9/factor IXa when it converts F10/factor X to the activated form, factor Xa.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone BO2C11"
- CAT
- Product Name
See other products for "F8"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-930-VHH | Recombinant Anti-Human F8 VHH Single Domain Antibody | ELISA, Neut, ICC, FC | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-259CL | Human Anti-F8 Recombinant Antibody (TAB-259CL) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBZ-044 | Human Anti-F8 Recombinant Antibody (clone BO2C11); scFv Fragment | Neut | Human scFv |
| HPAB-1979-FY-S(P) | Human Anti-F8 Recombinant Antibody (clone WR8); scFv Fragment | IP | Human scFv |
| HPAB-1980-FY-S(P) | Human Anti-F8 Recombinant Antibody (clone WR11); scFv Fragment | IP | Human scFv |
| HPAB-1981-FY-S(P) | Human Anti-F8 Recombinant Antibody (clone WR10); scFv Fragment | IP | Human scFv |
| FAMAB-0201JF-S(P) | Human Anti-F8 Recombinant Antibody (clone KM38); scFv Fragment | WB, ELISA, FuncS | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-014LC | Recombinant Anti-Human F8 Antibody (Fab glycosylation) | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-015LC | Recombinant Anti-Human F8 Antibody (Non-glycosylated) | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0376MZ | Recombinant Mouse Anti-Human Factor VIII Antibody (clone BIWIV-5026) | WB, ELISA | Mouse antibody |
| FAMAB-0197-CN | Human Anti-F8 Recombinant Antibody (clone KM33) | WB | Human IgG |
| HPAB-0793-FY | Mouse Anti-F8 Recombinant Antibody (clone 4F143) | Activ | Mouse IgG |
| HPAB-0794-FY | Mouse Anti-F8 Recombinant Antibody (clone 4F50) | Activ | Mouse IgG |
| FAMAB-0286JF | Human Anti-F8 Recombinant Antibody (clone VK34) | ELISA, FuncS | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-058 | Recombinant Human Anti-F8 Antibody (BO2C11) | WB, ELISA, FuncS, Inhib, PK, IP, SPR | IgG |
| PABX-058-S (P) | Recombinant Human Anti-F8 Antibody scFv Fragment (BO2C11) | WB, ELISA, FuncS | scFv |
| PABX-058-F (E) | Recombinant Human Anti-F8 Antibody Fab Fragment (BO2C11) | WB, ELISA, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-765CQ | Mouse Anti-F8 Recombinant Antibody (clone CBL215) | ELISA, WB, Neut | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1229 | Hi-Affi™ Rabbit Anti-F8 Recombinant Antibody (clone DS1229AB) | ELISA | Rabbit IgG |
| MOR-4166 | Hi-Affi™ Rabbit Anti-F8 Recombinant Antibody (clone SI243DS) | ELISA | Rabbit IgG |
| MOR-4167 | Hi-Affi™ Rabbit Anti-F8 Recombinant Antibody (clone SI244DS) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| EPAF-0611LC | Human Anti-F8 Recombinant Antibody (clone BO2C11) | ELISA | Human IgG4 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0197-CN-F(E) | Human Anti-F8 Recombinant Antibody (clone KM33); Fab Fragment | WB | Human Fab |
| HPAB-1242WJ-F(E) | Human Anti-F8 Recombinant Antibody (clone YK3.3.40); Fab Fragment | ELISA | Human Fab |
| HPAB-1243WJ-F(E) | Human Anti-F8 Recombinant Antibody (clone YK3.3.50); Fab Fragment | ELISA | Human Fab |
| HPAB-1979-FY-F(E) | Human Anti-F8 Recombinant Antibody (clone WR8); Fab Fragment | IP | Human Fab |
| HPAB-1980-FY-F(E) | Human Anti-F8 Recombinant Antibody (clone WR11); Fab Fragment | IP | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-YF075 | DRB1*11:01/Factor VIII Factor VIII (ENIQRFLPNPAGVQLEDPEF) MHC Monomer | MHC Multimer |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY94 | AbPlus™ Anti-F8 Magnetic Beads (JM4) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC76 | Recombinant Anti-F8 (A2 domain x C1 domain) Biparatopic Antibody, Tandem scFv (Clone JM4 x Clone KM33) | ELISA | Tandem scFv |
| VS-0525-YC78 | Recombinant Anti-F8 (AA 484-508 x AA 712-736) Biparatopic Antibody, Tandem scFv (Clone VK34 x Clone VK41) | ELISA | Tandem scFv |
| VS-0525-YC80 | Recombinant Anti-F8 (AA 1803-1818 x AA 2223-2332) Biparatopic Antibody, Tandem scFv (Clone KM41 x Clone WR8) | ELISA | Tandem scFv |
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