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F8

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This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.

Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
ELISA, IP, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab
Application:
WB, ELISA, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
scFv
Application:
WB, IHC, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
WB, ELISA, IF, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
scFv
Application:
WB, ELISA, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
scFv
Application:
WB, ELISA, FuncS
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Host animal:
Human
Specificity:
Human
Type:
Human antibody
Classification:
Fab glycosylation
Glycosylation site:
Asn47-Thr49 in heavy chain
Host animal:
Human
Specificity:
Human
Type:
Human antibody
Classification:
Non-glycosylated
Species Reactivity:
Human
Type:
Antibody
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
WB, ELISA, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
IgG
Application:
WB, ELISA, FuncS
Derivation:
Mouse
Species Reactivity:
Human
Type:
Fab
Application:
WB, ELISA, IF, FuncS
Derivation:
Human
Species Reactivity:
Human
Type:
IgG
Application:
Neut
Derivation:
Human
Species Reactivity:
Human
Application:
Neut
Application:
For in vitro and in vivo research use. Not intended for any applications in human.
Species Reactivity:
Human
Application:
ELISA
Species Reactivity:
Human
Application:
ELISA
Species Reactivity:
Human
Type:
Mouse antibody
Application:
WB, ELISA
Species Reactivity:
Human
Type:
Llama VHH
Application:
ELISA, Neut, ICC, FC
Species Reactivity:
Human
Type:
ADCC enhanced antibody
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