Anti-fibroblast activation proteinα-SMCC-DM1 ADC
CAT#: ADC-161LZY
This ADC product is composed of an anti-fibroblast activation proteinα antibody conjugated via SMCC linker to DM1 (anti-fibroblast activation proteinα-SMCC-DM1). It has demonstrated a response in Lung, pancreas, head and neck cancers treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.
Gene Expression
Normal Tissue
Figure 1 Colon
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/59739/134103_A_9_3.jpg
Normal Tissue
Figure 2 Liver
Cholangiocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/59739/134103_A_8_4.jpg
Normal Tissue
Figure 3 Kidney
Cells in tubules
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/59739/134103_A_7_5.jpg
Normal Tissue
Figure 4 Testis
Cells in seminiferous ducts
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/59739/134103_A_4_6.jpg
Normal Tissue
Figure 5 Smooth muscle
Smooth muscle cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/59739/134103_B_6_7.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, BJ hTERT+, hTERT-RPE1, U-138 MG)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000078098-FAP
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Specifications
- Linker
- SMCC (4-[N-maleimidomethyl] cyclohexane-1 carboxylhydrazide).
- Linker Class/Description
- Class: Noncleavable linker
Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation
- Drug
- DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
- Drug Class/Description
- Class: Maytansinoid
Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells
Target
- Introduction
- The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
- Alternative Names
- FAP; fibroblast activation protein, alpha; FAPA; SIMP; DPPIV; prolyl endopeptidase FAP; seprase; FAPalpha; dipeptidyl peptidase FAP; surface-expressed protease; post-proline cleaving enzyme; gelatine degradation protease FAP; integral membrane serine protease; serine integral membrane protease; 170 kDa melanoma membrane-bound gelatinase;
- Gene ID
- 2191
- UniProt ID
- B4DLR2
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MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2277z | Mouse Anti-FAP Recombinant Antibody (clone 36B12) | FC, IF, IP | Mouse IgG1 |
| MOB-1515MZ | Recombinant Mouse Anti-Human FAP Antibody | WB | Mouse antibody |
| HPAB-0172-CN | Human Anti-FAP Recombinant Antibody (HPAB-0172-CN) | ELISA, IHC | Chimeric (mouse/human) IgG1, κ |
| HPAB-0176-CN | Human Anti-FAP Recombinant Antibody (clone cF19) | ELISA, FC, IHC, IP, IF | Chimeric (mouse/human) IgG1 |
| VS-0723-WK245 | Rabbit Anti-FAP Recombinant Antibody (VS-0723-WK245) | ELISA, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-211 | Anti-Human FAP Recombinant Antibody (TAB-211) | ELISA, IP, FC, FuncS, Neut, IF, WB | IgG1 - kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-022WM | Human Anti-FAP Recombinant Antibody (TAB-022WM) | FC, ELISA | Human IgG1 |
| TAB-022WM-S(P) | Human Anti-FAP Recombinant Antibody; scFv Fragment (TAB-022WM-S(P)) | FC, ELISA | Human scFv |
| TAB-024WM-S(P) | Human Anti-FAP Recombinant Antibody; scFv Fragment (TAB-024WM-S(P)) | ELISA, FC, IF | Human scFv |
| TAB-022WM-F(E) | Human Anti-FAP Recombinant Antibody; Fab Fragment (TAB-022WM-F(E)) | FC, ELISA | Human Fab |
| TAB-024WM-F(E) | Human Anti-FAP Recombinant Antibody; Fab Fragment (TAB-024WM-F(E)) | ELISA, FC, IF | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-150LC-1 | Recombinant Anti-Human FAP Antibody (Fc glycosylation/Non fucosylated) | ELISA | Human antibody |
| Gly-151LC-1 | Recombinant Anti-Human FAP Antibody (Fc glycosylation/Non fucosylated) | ELISA | Human antibody |
| Gly-152LC-1 | Recombinant Anti-Human FAP Antibody (Fc glycosylation/Non fucosylated) | ELISA | Human antibody |
| Gly-153LC-1 | Recombinant Anti-Human FAP Antibody (Fc glycosylation/Non fucosylated) | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-153LC | Recombinant Anti-Human FAP Antibody (Fc glycosylation/Non fucosylated) | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0170-CN-S(P) | Human Anti-FAP Recombinant Antibody; scFv Fragment (HPAB-0170-CN-S(P)) | ELISA, IF | Human scFv |
| HPAB-0171-CN-S(P) | Mouse Anti-FAP Recombinant Antibody; scFv Fragment (HPAB-0171-CN-S(P)) | ELISA | Mouse scFv |
| HPAB-0173-CN-S(P) | Human Anti-FAP Recombinant Antibody; scFv Fragment (HPAB-0173-CN-S(P)) | ELISA | Humanized scFv |
| HPAB-0176-CN-S(P) | Mouse Anti-FAP Recombinant Antibody (clone cF19); scFv Fragment | ELISA, FC, IHC, IP, IF | Mouse scFv |
| HPAB-0668-YJ-S(P) | Human Anti-FAP Recombinant Antibody; scFv Fragment (HPAB-0668-YJ-S(P)) | ELISA, Inhib, IHC, IF, FuncS | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0172-CN-F(E) | Human Anti-FAP Recombinant Antibody; Fab Fragment (HPAB-0172-CN-F(E)) | ELISA, IHC | Chimeric (mouse/human) Fab |
| HPAB-0176-CN-F(E) | Human Anti-FAP Recombinant Antibody (clone cF19); Fab Fragment | ELISA, FC, IHC, IP, IF | Chimeric (mouse/human) Fab |
| HPAB-0668-YJ-F(E) | Human Anti-FAP Recombinant Antibody; Fab Fragment (HPAB-0668-YJ-F(E)) | ELISA, Inhib, IHC, IF, FuncS | Human Fab |
| HPAB-2061-FY-F(E) | Human Anti-FAP Recombinant Antibody; Fab Fragment (HPAB-2061-FY-F(E)) | FC, ELISA, IF | Human Fab |
| HPAB-2062-FY-F(E) | Human Anti-FAP Recombinant Antibody; Fab Fragment (HPAB-2062-FY-F(E)) | FC, ELISA, IF | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0619-CN | Recombinant Dromedary Anti-FAP Single Domain Antibody (HPAB-0619-CN) | ELISA | VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-211 | Afuco™ Anti-FAP ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-211) | ELISA, IP, FC, FuncS, Neut, IF | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0661 | PE-H-2Kb/Human FAP (SDYYFSWL) MHC Tetramer | FCM, IHC | |
| MHC-CN0662 | APC-H-2Kb/Human FAP (SDYYFSWL) MHC Tetramer | FCM, IHC | |
| MHC-YF431 | A*02:01/Human FAP (GLFKCGIAV) MHC Pentamer | FCM | |
| MHC-YF432 | A*02:01/Human FAP alpha (ALVCYGPGI) MHC Pentamer | FCM | |
| MHC-YF573 | H-2Kb/Human muFAP alpha (SDYYFSWL) MHC Pentamer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY97 | AbPlus™ Anti-FAP Magnetic Beads (ESC14) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY118 | Human Anti-FAP (clone cF19) scFv-Fc Chimera | FC, IHC, IP | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY813 | Anti-FAP Immunohistochemistry Kit | IHC | |
| VS-0525-XY2444 | Anti-Human FAP Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC379 | CytoStream™ Mouse Anti-FAP Recombinant Antibody (VS13-YC379) | IHC-P, FC, ELISA | Mouse IgG1 |
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