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    Human Anti-FAP (clone cF19) scFv-Fc Chimera (CAT#: VS-0325-FY118)

    The anti-FAPα scFv-Fc antibody targets fibroblast activation protein alpha (FAPα), a serine protease expressed in cancer-associated fibroblasts. It is useful for studying the role of FAPα in tumor stroma remodeling, angiogenesis, and cancer progression.

    Specific Inquiry
    • Size:

    • Conjugation:

    • Endotoxin:

    • Purity:

    • Formats:

    • Isotype Switching:

    • Fc Engineering:

    • Modalities:

    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

    Sequences:
    Isotype :
    Purity :
    Endotoxin :
    Quantity :
    Conjugation :
    Fc Engineering :
    Modalities :
    Other Requirements:
    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Normal Tissue
    Figure 1 Colon
    Figure 1 Colon
    (Endothelial cells
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous
    Glandular cells
    Staining:High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/59739/134103_A_9_3.jpg
    Figure 2 Liver
    Figure 2 Liver
    (Cholangiocytes
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/59739/134103_A_8_4.jpg
    Figure 3 Kidney
    Figure 3 Kidney
    (Cells in tubules
    Staining:Medium
    Intensity: Strong
    Quantity: <25%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/59739/134103_A_7_5.jpg
    Figure 4 Testis
    Figure 4 Testis
    (Cells in seminiferous ducts
    Staining:High
    Intensity: Strong
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/59739/134103_A_4_6.jpg
    Figure 5 Smooth muscle
    Figure 5 Smooth muscle
    (Smooth muscle cells
    Staining:High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/59739/134103_B_6_7.jpg
    RNA Expression
    Figure 6 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, BJ hTERT+, hTERT-RPE1, U-138 MG)
    Figure 6 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, BJ hTERT+, hTERT-RPE1, U-138 MG)
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000078098-FAP

    Specifications

    • Host Species
    • Human
    • Type
    • Human IgG1, scFv-Fc
    • Specificity
    • Human FAP
    • Species Reactivity
    • Human
    • Clone
    • cF19
    • Applications
    • Flow Cytometry, Immunohistochemistry, Immunoprecipitation
    • Related Disease
    • Cancer

    Product Property

    • Purity
    • >95% as determined by SDS-PAGE
    • Concentration
    • Please refer to the vial label for the specific concentration.
    • Storage
    • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
    • Shipping
    • Ice packs

    Applications

    • Application Notes
    • Flow Cytometry: 1 pg/mL

    Target

    • Alternative Names
    • Fibroblast Activation Protein Alpha; Seprase; 170 KDa Melanoma Membrane-Bound Gelatinase; Gelatine Degradation Protease FAP; Integral Membrane Serine Protease; Post-Proline Cleaving Enzyme; Surface-Expressed Protease; Dipeptidyl Peptidase FAP; FAPalpha; SIMP
    • Long Name
    • Fibroblast Activation Protein Alpha
    • Function
    • FAP is a type II transmembrane serine protease that is overexpressed in cancer-associated fibroblasts (CAFs) within the tumor microenvironment. It plays a role in the degradation of the extracellular matrix (ECM), promoting tumor growth, invasion, and metastasis. FAP also influences cell signaling pathways involved in tissue remodeling and wound healing, contributing to the desmoplastic reaction characteristic of many solid tumors.

    Recommended Products

    Isotype Control

    Secondary Antibody

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    See other products for "Clone cF19"

    See other products for "Fap"

    Select a product category from the dropdown menu below to view related products.
    Please select product type
    Humanized Antibody Products Human Antibody Products Low- or Non-fucosylated Oligosaccharide Antibody Products Fc Glycosylation Antibody Products IgG Antibody Products ScFv Antibody Products Fab Antibody Products Single Domain Antibody Products ADCC Enhanced Antibody Products MHC Tetramer Products for Cancer Antibody Magnetic Beads IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry Flow Cytometry (FC) related Reagents and Kits: Empowering Cell Function Research
    CAT Product Name Application Type
    TAB-211 Anti-Human FAP Recombinant Antibody (TAB-211) ELISA, IP, FC, FuncS, Neut, IF, WB IgG1 - kappa

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    For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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