Afuco™ Anti-FLT1 ADCC Recombinant Antibody (Icrucumab), ADCC Enhanced (CAT#: AFC-TAB-177)
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to VEGFR-1. Icrucumab is a human monoclonal antibody designed for the treatment of solid tumors.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11740/90_G3_2_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11740/90_G3_2_selected.jpg
Figure 2 IF staining of human cell line BJ
(Immunofluorescent staining of human cell line BJ shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11740/1368_A5_2_blue_green.jpg
(Immunofluorescent staining of human cell line BJ shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11740/1368_A5_2_blue_green.jpg
Figure 3 Testis
(Peritubular cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Sertoli cells
Staining: Medium
Intensity: Moderate
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11740/142518_A_6_6.jpg
(Peritubular cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Sertoli cells
Staining: Medium
Intensity: Moderate
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11740/142518_A_6_6.jpg
Figure 4 RNA cell line category: Cell line enhanced (BJ, BJ hTERT+, HMC-1, HUVEC TERT2, WM-115)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000102755-FLT1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000102755-FLT1
Figure 4 RNA cell line category: Cell line enhanced (BJ, BJ hTERT+, HMC-1, HUVEC TERT2, WM-115)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000102755-FLT1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000102755-FLT1
Specifications
- Immunogen
- Recombinant human soluble extracellular Flt-1 Ig-like loop 1 to 5 (sFlt-1(D5)).
- Host Species
- Human
- Derivation
- Human
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Clone
- Icrucumab
- Applications
- IF, IP, Neut, FuncS, ELISA, FC
- Conjugate
- Unconjugated
- Generic Name
- Icrucumab
- Related Disease
- Colon cancers
Product Property
- Purity
- >95% by SDS-PAGE
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Icrucumab; 1024603-92-6; IMC-18F1; IMC18F1; FLT1; fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor); FLT; vascular endothelial growth factor receptor 1; VEGFR1; FLT-1; VEGFR-1; fms-like tyrosine kinase 1;
- Gene ID
- 2321
- UniProt ID
- P17948
Related Resources
Please refer to Icrucumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Icrucumab.
Rheumatoid Arthritis
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Icrucumab"
Anti-Human VEGFR-1 Recombinant Antibody (Icrucumab)Recombinant monoclonal antibody to VEGFR-1. Icrucumab is a human monoclonal antibody designed for the treatment of solid tumors.
See other products for "FLT1"
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-177 | Anti-Human VEGFR-1 Recombinant Antibody (Icrucumab) | IF, IP, Neut, FuncS, ELISA, FC, WB | IgG1 - kappa |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-008CQ | Mouse Anti-FLT1 Recombinant Antibody (TAB-008CQ) | ELISA, FC | Mouse IgG |
| TAB-008CQ-S(P) | Mouse Anti-FLT1 Recombinant Antibody; scFv Fragment (TAB-008CQ-S(P)) | ELISA, FC | Mouse scFv |
| TAB-008CQ-F(E) | Mouse Anti-FLT1 Recombinant Antibody; Fab Fragment (TAB-008CQ-F(E)) | ELISA, FC | Mouse Fab |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-009CQ | Human Anti-FLT1 Recombinant Antibody (TAB-009CQ) | ELISA | Chimeric antibody (mouse/human) |
| TAB-009CQ-S(P) | Mouse Anti-FLT1 Recombinant Antibody; scFv Fragment (TAB-009CQ-S(P)) | ELISA | Mouse scFv |
| TAB-009CQ-F(E) | Human Anti-FLT1 Recombinant Antibody; Fab Fragment (TAB-009CQ-F(E)) | ELISA | Chimeric antibody (mouse/human) |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-845CQ | Mouse Anti-FLT1 Recombinant Antibody (clone MAB0702) | WB, Block | Mouse IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1322 | Hi-Affi™ Rabbit Anti-FLT1 Recombinant Antibody (clone DS1322AB) | WB, IHC-P, ICC, IF, IP, ELISA, IHC-P, IHC-Fr | Rabbit IgG |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0785-CN | Mouse Anti-FLT1 Recombinant Antibody (clone 1-833-527) | ELISA, FC | Mouse IgG, κ |
| MRO-1579-CN | Rabbit Anti-FLT1 Recombinant Antibody (clone CBACN-579) | WB, IF, IHC, IP, FC | Rabbit IgG |
| HPAB-0499-YJ | Human Anti-FLT1 Recombinant Antibody (HPAB-0499-YJ) | ELISA, Block, FuncS | Human IgG1 |
| HPAB-0500-YJ | Human Anti-FLT1 Recombinant Antibody (HPAB-0500-YJ) | ELISA, Block, FuncS | Human IgG4 |
| HPAB-0501-YJ | Mouse Anti-FLT1 Recombinant Antibody (HPAB-0501-YJ) | ELISA, Block, FuncS | Chimeric (mouse/rat) IgG1 |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0785-CN-S(P) | Mouse Anti-FLT1 Recombinant Antibody (clone 1-833-527); scFv Fragment | ELISA, FC | Mouse scFv |
| HPAB-1606LY-S(P) | Human Anti-FLT1 Recombinant Antibody; scFv Fragment (HPAB-1606LY-S(P)) | ELISA | Human scFv |
| HPAB-1607LY-S(P) | Human Anti-FLT1 Recombinant Antibody; scFv Fragment (HPAB-1607LY-S(P)) | ELISA | Human scFv |
| HPAB-1609LY-S(P) | Human Anti-FLT1 Recombinant Antibody; scFv Fragment (HPAB-1609LY-S(P)) | ELISA | Human scFv |
| HPAB-M0695-YC-S(P) | Mouse Anti-FLT1 Recombinant Antibody; scFv Fragment (HPAB-M0695-YC-S(P)) | ELISA, WB, FuncS | Mouse scFv |
MHC Tetramer for Cancer
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0673 | PE-A*02:01/Human FLT1 (TLFWLLTL) MHC Tetramer | FCM, IHC | |
| MHC-CN0674 | APC-A*02:01/Human FLT1 (TLFWLLTL) MHC Tetramer | FCM, IHC | |
| MHC-CN0675 | FITC-A*02:01/Human FLT1 (TLFWLLTL) MHC Tetramer | FCM, IHC | |
| MHC-CN1412 | PE-A*24:02/Human FLT1 (SYGVLLWEI) MHC Tetramer | FCM | |
| MHC-YF771 | A*02:01/Human VEGFR1 (GVLLWEIFSL) MHC Pentamer | FCM |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0065-YJ-F(E) | Mouse Anti-FLT1 Recombinant Antibody (clone 6.12); Fab Fragment | Inhib | Mouse Fab |
| HPAB-1699-FY-S(P) | Mouse Anti-FLT1 Recombinant Antibody (clone CA0071-Z2ZM-01941); Fab Fragment | ELISA | Mouse Fab |
| HPAB-1700-FY-S(P) | Mouse Anti-FLT1 Recombinant Antibody (clone CA0071-Z2ZA-01171); Fab Fragment | ELISA | Mouse Fab |
| HPAB-1701-FY-S(P) | Mouse Anti-FLT1 Recombinant Antibody (clone CA0071-Z2ZB-01171); Fab Fragment | ELISA | Mouse Fab |
| HPAB-1702-FY-S(P) | Human Anti-FLT1 Recombinant Antibody (clone 6F9); Fab Fragment | ELISA, WB | Human Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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