Human Anti-IFNAR1 Recombinant Antibody (clone H2K1) (CAT#: HPAB-J0127-YC)
Provided is a humanized antibody which bind to interferon alpha receptor-1 (IFNAR1). The antibody can be used to some applications including ELISA, Flow cytometry and inhibition.
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
Figure 1 Ex vivo analysis. Spleen cells from BXSB mice (16 wk old, n = 3) were examined by flow cytometry to assess cell-surface IFNAR expression after gating on various cells.
Background staining (gray-lined histograms) and IFNAR levels in noncultured ex vivo B cells (gray-filled histograms) are also depicted.
Baccala, R., Gonzalez-Quintial, R., Schreiber, R. D., Lawson, B. R., Kono, D. H., & Theofilopoulos, A. N. (2012). Anti–IFN-α/β Receptor Antibody Treatment Ameliorates Disease in Lupus-Predisposed Mice. The Journal of Immunology, 189(12), 5976-5984.
Figure 2 Effects of IFNAR blockade in DC subsets.
Bars represent average of individual mice (n = 3).
Baccala, R., Gonzalez-Quintial, R., Schreiber, R. D., Lawson, B. R., Kono, D. H., & Theofilopoulos, A. N. (2012). Anti–IFN-α/β Receptor Antibody Treatment Ameliorates Disease in Lupus-Predisposed Mice. The Journal of Immunology, 189(12), 5976-5984.
Figure 3 Late anti–IFNAR Ab treatment of BXSB mice.
Kidney glomerular IgG2a deposits and immunocyte infiltration (CD11b+ and CD11c+ ) at 33 wk.
Baccala, R., Gonzalez-Quintial, R., Schreiber, R. D., Lawson, B. R., Kono, D. H., & Theofilopoulos, A. N. (2012). Anti–IFN-α/β Receptor Antibody Treatment Ameliorates Disease in Lupus-Predisposed Mice. The Journal of Immunology, 189(12), 5976-5984.
Specifications
- Host Species
- Human
- Derivation
- Humanized (mouse/human)
- Type
- Humanized (mouse/human) IgG
- Specificity
- Human IFNAR1
- Species Reactivity
- Human, Monkey
- Clone
- H2K1
- Applications
- FC, IHC, ELISA
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The IFNAR1 antibody has been reported in applications of Enzyme-linked Immunosorbent Assay, Flow Cytometry, Immunohistochemistry.
Target
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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CAT | Product Name | Application | Type |
---|---|---|---|
PSBL-228 | Human Anti-IFNAR1 Recombinant Antibody (clone MEDI546); scFv Fragment | WB, ELISA, FuncS | Human scFv |
HPAB-0158-CN-S(P) | Human Anti-IFNAR1 Recombinant Antibody (clone S3A5); scFv Fragment | ELISA | Human scFv |
HPAB-0159-CN-S(P) | Human Anti-IFNAR1 Recombinant Antibody (clone S5B4); scFv Fragment | ELISA | Human scFv |
HPAB-0160-CN-S(P) | Human Anti-IFNAR1 Recombinant Antibody (clone AmS3A5-1); scFv Fragment | ELISA | Human scFv |
HPAB-0161-CN-S(P) | Human Anti-IFNAR1 Recombinant Antibody (clone AmS3A5-2); scFv Fragment | ELISA | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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