Human Anti-IFNAR1 Recombinant Antibody (clone H2K1) (CAT#: HPAB-J0127-YC)
Provided is a humanized antibody which bind to interferon alpha receptor-1 (IFNAR1). The antibody can be used to some applications including ELISA, Flow cytometry and inhibition.
Specific Inquiry
FC
Figure 1 Ex vivo analysis. Spleen cells from BXSB mice (16 wk old, n = 3) were examined by flow cytometry to assess cell-surface IFNAR expression after gating on various cells.
Background staining (gray-lined histograms) and IFNAR levels in noncultured ex vivo B cells (gray-filled histograms) are also depicted.
Baccala, R., Gonzalez-Quintial, R., Schreiber, R. D., Lawson, B. R., Kono, D. H., & Theofilopoulos, A. N. (2012). Anti–IFN-α/β Receptor Antibody Treatment Ameliorates Disease in Lupus-Predisposed Mice. The Journal of Immunology, 189(12), 5976-5984.
ELISA
Figure 2 Effects of IFNAR blockade in DC subsets.
Bars represent average of individual mice (n = 3).
Baccala, R., Gonzalez-Quintial, R., Schreiber, R. D., Lawson, B. R., Kono, D. H., & Theofilopoulos, A. N. (2012). Anti–IFN-α/β Receptor Antibody Treatment Ameliorates Disease in Lupus-Predisposed Mice. The Journal of Immunology, 189(12), 5976-5984.
IHC
Figure 3 Late anti–IFNAR Ab treatment of BXSB mice.
Kidney glomerular IgG2a deposits and immunocyte infiltration (CD11b+ and CD11c+ ) at 33 wk.
Baccala, R., Gonzalez-Quintial, R., Schreiber, R. D., Lawson, B. R., Kono, D. H., & Theofilopoulos, A. N. (2012). Anti–IFN-α/β Receptor Antibody Treatment Ameliorates Disease in Lupus-Predisposed Mice. The Journal of Immunology, 189(12), 5976-5984.
Specifications
- Host Species
- Human
- Derivation
- Humanized (mouse/human)
- Type
- Humanized (mouse/human) IgG
- Specificity
- Human IFNAR1
- Species Reactivity
- Human, Monkey
- Clone
- H2K1
- Applications
- FC, IHC, ELISA
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The IFNAR1 antibody has been reported in applications of Enzyme-linked Immunosorbent Assay, Flow Cytometry, Immunohistochemistry.
Target
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1305z-S(P) | Recombinant Anti-Human IFNAR1 Antibody scFv Fragment | RIA, ELISA, FuncS | scFv |
| PSBL-228 | Human Anti-IFNAR1 Recombinant Antibody (clone MEDI546); scFv Fragment | WB, ELISA, FuncS | Human scFv |
| HPAB-0203CQ-S(P) | Human Anti-IFNAR1 Recombinant Antibody (clone H3K1); scFv Fragment | ELISA, FC, Inhib | Humanized scFv |
| HPAB-J0126-YC-S(P) | Human Anti-IFNAR1 Recombinant Antibody (clone ch64G12); scFv Fragment | ELISA, FC | Mouse scFv |
| HPAB-J0127-YC-S(P) | Human Anti-IFNAR1 Recombinant Antibody (clone H2K1); scFv Fragment | ELISA, FC | Humanized (mouse/human) scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-228 | Human Anti-IFNAR1 Recombinant Antibody (clone MEDI546); Fab Fragment | WB, ELISA, FuncS | Human Fab |
| HPAB-0158-CN-F(E) | Human Anti-IFNAR1 Recombinant Antibody (clone S3A5); Fab Fragment | ELISA | Human Fab |
| HPAB-0159-CN-F(E) | Human Anti-IFNAR1 Recombinant Antibody (clone S5B4); Fab Fragment | ELISA | Human Fab |
| HPAB-0160-CN-F(E) | Human Anti-IFNAR1 Recombinant Antibody (clone AmS3A5-1); Fab Fragment | ELISA | Human Fab |
| HPAB-0161-CN-F(E) | Human Anti-IFNAR1 Recombinant Antibody (clone AmS3A5-2); Fab Fragment | ELISA | Human Fab |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-130CT | Anti-Human IFNAR-1 Recombinant Antibody (64G12) | WB, IF, FuncS | |
| TAB-130CT-S(P) | Anti-Human IFNAR-1 Recombinant Antibody scFv Fragment (64G12) | ELISA, FC | |
| TAB-130CT-F(E) | Anti-Human IFNAR-1 Recombinant Antibody Fab Fragment (64G12) | ELISA, FC |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-131CT | Anti-Human IFNAR-1 Recombinant Antibody (CPI-1697) | ELISA, FC | Humanized antibody |
| TAB-131CT-S(P) | Anti-Human IFNAR-1 Recombinant Antibody scFv Fragment (CPI-1697) | ELISA, FC | Humanized antibody |
| TAB-131CT-F(E) | Anti-Human IFNAR-1 Recombinant Antibody Fab Fragment (CPI-1697) | ELISA, FC | Humanized antibody |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-976CQ | Mouse Anti-Ifnar1 Recombinant Antibody (clone MAR1-5A3) | FC, Neut, IP, WB, B | Mouse IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1740 | Rabbit Anti-IFNAR1 Recombinant Antibody (clone DS1740AB) | WB, FC, IP | Rabbit IgG |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0158-CN | Human Anti-IFNAR1 Recombinant Antibody (clone S3A5) | FC | Human IgG |
| HPAB-0159-CN | Human Anti-IFNAR1 Recombinant Antibody (clone S5B4) | FC | Human IgG |
| HPAB-0160-CN | Human Anti-IFNAR1 Recombinant Antibody (clone AmS3A5-1) | ELISA | Human IgG1, κ |
| HPAB-0161-CN | Human Anti-IFNAR1 Recombinant Antibody (clone AmS3A5-2) | ELISA | Human IgG1, κ |
| MRO-1956-CN | Rabbit Anti-IFNAR1 Polyclonal Antibody (MRO-1956-CN) | IF, IHC | Rabbit IgG |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-722 | Afuco™ Anti-IFNAR ADCC Recombinant Antibody (Anifrolumab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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