Mouse Anti-IGF2 Recombinant Antibody (clone ABT-IGF2) (CAT#: VS3-CJ259)
This product is a mouse antibody that recognizes IGF2.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line CACO-2
(Immunofluorescent staining of human cell line CACO-2 shows localization to nucleoplasm & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7993/1030_B7_2_selected.jpg
(Immunofluorescent staining of human cell line CACO-2 shows localization to nucleoplasm & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7993/1030_B7_2_selected.jpg
Figure 2 High expression in placenta
(Decidual cells Staining: High Intensity: Strong Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7556/156845_A_2_7.jpg
(Decidual cells Staining: High Intensity: Strong Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7556/156845_A_2_7.jpg
Figure 3 RNA cell line category: Cell line enhanced (CACO-2, Hep G2, LHCN-M2, RH-30, SH-SY5Y)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000167244-IGF2
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000167244-IGF2
Specifications
- Immunogen
- Synthesized peptide derived from human IGF-2
- Host Species
- Mouse
- Type
- Mouse IgG2b, κ
- Specificity
- Human IGF2
- Species Reactivity
- Human
- Clone
- ABT-IGF2
- Applications
- IHC-P
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity chromatography
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- 50% Glycerol, 0.5% BSA, PBS.
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- This antibody has been tested for use in Immunohistochemistry-Parraffin (1:100-1:500).
Target
- Alternative Names
- Insulin-like growth factor II; IGF-II; Somatomedin-A; GRDF; PP9974; C11orf43; T3M-11-derived growth factor
- Gene ID
- 3481
- UniProt ID
- P01344
- Sequence Similarities
- Belongs to the insulin family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- O-glycosylated with core 1 or possibly core 8 glycans. Thr-96 is a minor glycosylation site compared to Thr-99.
Proteolytically processed by PCSK4, proIGF2 is cleaved at Arg-128 and Arg-92 to generate big-IGF2 and mature IGF2.
- Protein Refseq
- NP_000603.1; NP_001007140.2; NP_001121070.1
- Function
- The insulin-like growth factors possess growth-promoting activity (By similarity).
Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF2 is influenced by placental lactogen. Also involved in tissue differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver (Probable). Acts as a ligand for integrin which is required for IGF2 signaling (PubMed:28873464).
Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (By similarity).
Inhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate (By similarity).
Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.
Recommended Products
Isotype Control
Recommended Dilution Buffer
Related Resources
Endocrine Resistance
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-740 | Anti-IGF2 Recombinant Antibody (Dusigitumab) | Neut, ELISA, IF, IP, FuncS, FC, ICC | IgG2 |
| TAB-387CL | Anti-Human IGF2 Recombinant Antibody (DX-2647) | BL, Inhib | Antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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