Human Anti-IGF2 Recombinant Antibody (clone m610) (CAT#: HPAB-1734-FY)
This product is a recombinant antibody that recognizes IGF2. The monoclonal antibody m610 reacts with the epitope of IGF2. M610 inhibit IGF-IR phosphorylation in a wide variety of cancer cells.
Specific Inquiry
ELISA
Figure 1 In vitro binding of IgG1 m606 and m610 to mature and precursor forms of IGF-II immobilized on ELISA plate.
Binding of the antibodies was measured by ELISA with 50 ng of either mature or precursor IGF-II immobilized on plates. OD405, absorbance at 405 nm.
Feng, Y., Zhu, Z., Xiao, X., Choudhry, V., Barrett, J. C., & Dimitrov, D. S. (2006). Novel human monoclonal antibodies to insulin-like growth factor (IGF)-II that potently inhibit the IGF receptor type I signal transduction function. Molecular cancer therapeutics, 5(1), 114-120.
Inhib
Figure 2 IgG m610 inhibited DU145 cell growth and reduced motility of MCF-7 cells in medium containing 5% fetal bovine serum.
DU145 cells were starved in serum-free medium for 6 h followed by incubation with IGF-II at 10 nmol/L final concentration and IgG m610 at the indicated final concentrations.
Feng, Y., Zhu, Z., Xiao, X., Choudhry, V., Barrett, J. C., & Dimitrov, D. S. (2006). Novel human monoclonal antibodies to insulin-like growth factor (IGF)-II that potently inhibit the IGF receptor type I signal transduction function. Molecular cancer therapeutics, 5(1), 114-120.
Specifications
- Host Species
- Human
- Type
- Human IgG
- Specificity
- Human IGF2
- Species Reactivity
- Human
- Clone
- m610
- Applications
- Inhib, WB, ELISA
- Related Disease
- Breast cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The IGF2 antibody has been reported in applications of Inhibition, Western Blot, Enzyme-linked Immunosorbent Assay.
Target
Related Resources
Endocrine Resistance
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone m610"
See other products for "IGF2"
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-740 | Anti-IGF2 Recombinant Antibody (Dusigitumab) | Neut, ELISA, IF, IP, FuncS, FC, ICC | IgG2 |
| TAB-387CL | Anti-Human IGF2 Recombinant Antibody (DX-2647) | BL, Inhib | Antibody |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-231 | Human Anti-IGF2 Recombinant Antibody (clone DX-2647); Fab Fragment | WB, ELISA, FuncS | Human Fab |
| HPAB-0613-WJ-F(E) | Human Anti-IGF2 Recombinant Antibody (clone m610.27); Fab Fragment | ELISA, WB | Humanized Fab |
| HPAB-1733-FY-S(P) | Human Anti-IGF2 Recombinant Antibody (clone M606); Fab Fragment | Inhib, WB, ELISA | Human Fab |
| HPAB-1734-FY-S(P) | Human Anti-IGF2 Recombinant Antibody (clone m610); Fab Fragment | Inhib, WB, ELISA | Human Fab |
| HPAB-1735-FY-S(P) | Human Anti-IGF2 Recombinant Antibody (clone m616); Fab Fragment | Inhib, WB, ELISA | Human Fab |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2250MZ | Recombinant Mouse Anti-Human IGF2 Antibody (clone nBcdbn74305) | WB | Mouse antibody |
| VS3-CJ258 | Mouse Anti-IGF2 Recombinant Antibody (clone PT1543) | IHC-P | Mouse IgG2b, κ |
| VS3-CJ259 | Mouse Anti-IGF2 Recombinant Antibody (clone ABT-IGF2) | IHC-P | Mouse IgG2b, κ |
| VS3-CJ260 | Mouse Anti-IGF2 Recombinant Antibody (VS3-CJ260) | IHC | Mouse IgG2b |
| VS3-CJ261 | Rabbit Anti-IGF2 Recombinant Antibody (VS3-CJ261) | WB, ICC, IF, IHC | Rabbit IgG |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1083CQ | Mouse Anti-IGF2 Recombinant Antibody (clone CBL493) | Neut | Mouse IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1756 | Rabbit Anti-IGF2 Recombinant Antibody (clone DS1756AB) | ELISA | Rabbit IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0037LY-S(P) | Human Anti-IGF2 Recombinant Antibody; scFv Fragment (HPAB-0037LY-S(P)) | WB | Human scfv |
| HPAB-0613-WJ-S(P) | Human Anti-IGF2 Recombinant Antibody (clone m610.27); scFv Fragment | ELISA, WB | Humanized scFv |
| HPAB-1733-FY-F(E) | Human Anti-IGF2 Recombinant Antibody (clone M606); scFv Fragment | Inhib, WB, ELISA | Human scFv |
| HPAB-1734-FY-F(E) | Human Anti-IGF2 Recombinant Antibody (clone m610); scFv Fragment | Inhib, WB, ELISA | Human scFv |
| HPAB-1735-FY-F(E) | Human Anti-IGF2 Recombinant Antibody (clone m616); scFv Fragment | Inhib, WB, ELISA | Human scFv |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-740 | Afuco™ Anti-IGF2 ADCC Recombinant Antibody (Dusigitumab), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for HPAB-1734-FY. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.