Mouse Anti-IGF2 Recombinant Antibody (clone PT1543)
CAT#: VS3-CJ258
This product is a mouse antibody that recognizes IGF2.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line CACO-2
Immunofluorescent staining of human cell line CACO-2 shows localization to nucleoplasm & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7993/1030_B7_2_selected.jpg
Normal Tissue
Figure 2 High expression in placenta
Decidual cells Staining: High Intensity: Strong Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7556/156845_A_2_7.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enhanced (CACO-2, Hep G2, LHCN-M2, RH-30, SH-SY5Y)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000167244-IGF2
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Specifications
- Immunogen
- Synthesized peptide derived from human IGF-2
- Host Species
- Mouse
- Type
- Mouse IgG2b, κ
- Specificity
- Human IGF2
- Species Reactivity
- Human
- Clone
- PT1543
- Applications
- IHC-P
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity chromatography
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- 50% Glycerol, 0.5% BSA, PBS.
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- This antibody has been tested for use in Immunohistochemistry-Parraffin (1:100-1:500).
Target
- Alternative Names
- Insulin-like growth factor II; IGF-II; Somatomedin-A; GRDF; PP9974; C11orf43; T3M-11-derived growth factor
- Gene ID
- 3481
- UniProt ID
- P01344
- Sequence Similarities
- Belongs to the insulin family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- O-glycosylated with core 1 or possibly core 8 glycans. Thr-96 is a minor glycosylation site compared to Thr-99.
Proteolytically processed by PCSK4, proIGF2 is cleaved at Arg-128 and Arg-92 to generate big-IGF2 and mature IGF2.
- Protein Refseq
- NP_000603.1; NP_001007140.2; NP_001121070.1
- Function
- The insulin-like growth factors possess growth-promoting activity (By similarity).
Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF2 is influenced by placental lactogen. Also involved in tissue differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver (Probable). Acts as a ligand for integrin which is required for IGF2 signaling (PubMed:28873464).
Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (By similarity).
Inhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate (By similarity).
Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.
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Related Diseases
Endocrine Resistance
Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
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| CAT | Product Name | Application | Type |
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| PFBL-231 | Human Anti-IGF2 Recombinant Antibody Fab Fragment (PFBL-231) | WB, ELISA, FuncS | Human Fab |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1083CQ | Mouse Anti-IGF2 Recombinant Antibody (clone CBL493) | Neut | Mouse IgG1 |
| CAT | Product Name | Application | Type |
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| MOR-1756 | Rabbit Anti-IGF2 Recombinant Antibody (clone DS1756AB) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0037LY-S(P) | Human Anti-IGF2 Recombinant Antibody; scFv Fragment (HPAB-0037LY-S(P)) | WB | Human scfv |
| HPAB-0613-WJ-S(P) | Human Anti-IGF2 Recombinant Antibody (clone m610.27); scFv Fragment | ELISA, WB | Humanized scFv |
| HPAB-1733-FY-F(E) | Human Anti-IGF2 Recombinant Antibody (clone M606); scFv Fragment | Inhib, WB, ELISA | Human scFv |
| HPAB-1734-FY-F(E) | Human Anti-IGF2 Recombinant Antibody (clone m610); scFv Fragment | Inhib, WB, ELISA | Human scFv |
| HPAB-1735-FY-F(E) | Human Anti-IGF2 Recombinant Antibody (clone m616); scFv Fragment | Inhib, WB, ELISA | Human scFv |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC84 | Recombinant Anti-IGF2 Vesicular Antibody, EV Displayed (VS-0425-YC84) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3433 | Anti-IGF2 Immunohistochemistry Kit | IHC |
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