Anti-IL17A Antibody-Cytokine Fusion Protein, IgG (Vunakizumab)-IL22
CAT#: VS-0624-FY84
Vunakizumab is a recombinant humanized IgG, κappa monoclonal antibody that binds to and neutralizes the proinflammatory cytokine interleukin 17A (IL-17A). IL-22 is produced by several immune cell populations at sites of inflammation. IL-22 acts on non-hematopoietic cells, primarily stromal and epithelial cells. Its effects include stimulation of cell survival, proliferation, and synthesis of antimicrobial agents, including S100, Reg3β, Reg3γ, and defensins. This product is a novel bifunctional fusion protein, Vunakizumab-IL22 (vmab-mIL22), which has the activities of IL-22 and anti-IL-17A antibody. It can be used as a new approach to treat influenza A virus infection. vmab-mIL22 was constructed by genetically fusing mouse IL22 (mIL22) to the C-terminus of the heavy chain of anti-IL-17A antibody (Vunakizumab, vmab) via a (Gly4Ser)3 linker.








Specifications
- Target
- IL-17A
- Molecule Class
- IgG-IL22
- Species Reactivity
- Human
- Clone
- Vunakizumab
- Related Disease
- Inflammatory bowel diseases
- Cytokine 1
- IL22
- Cytokines 1 Description
- IL-22 is an alpha-helical cytokine. IL-22 binds to a heterodimeric cell surface receptor composed of IL-10R2 and IL-22R1 subunits. IL-22R is expressed on tissue cells and absent on immune cells.
Crystallization was possible if the N-linked glycosylation site was removed in an IL-22 mutant that binds to the high-affinity cell surface receptor sIL-22R1. The crystal asymmetric unit contains two IL-22-sIL-22R1 complexes.
- Cytokine 1 Species
- Mouse
- Applications
- This product is for immuno therapy research. It can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Introduction
- The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
- Alternative Names
- Interleukin 17A; vmab-mIL22
- Gene ID
- 3605
- UniProt ID
- Q16552
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Related Diseases
Downloadable Resources
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Datasheet
MSDS
COA
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CAT | Product Name | Application | Type |
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TAB-H57 | Anti-Human IL17A Recombinant Antibody (Perakizumab) | WB, ELISA, IP, FC, FuncS, Neut, IF | IgG1 - kappa |
TAB-H08 | Anti-Human IL17A/IL17F Recombinant Antibody (TAB-H08) | ELISA, FC, IP, FuncS, IF, Neut, WB | IgG1 - kappa |
TAB-048ZJ | Human Anti-IL17A Recombinant Antibody (TAB-048ZJ) | ELISA, Neut | Humanized antibody |
TAB-048ZJ-S(P) | Human Anti-IL17A Recombinant Antibody; scFv Fragment (TAB-048ZJ-S(P)) | ELISA, Neut | Human scFv |
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CAT | Product Name | Application | Type |
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TAB-399CL | Human Anti-IL17A Recombinant Antibody (TAB-399CL) | ELISA | Human IgG |
CAT | Product Name | Application | Type |
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TAB-030ZJ | Mouse Anti-IL17A Recombinant Antibody (TAB-030ZJ) | ELISA, Neut | Mouse IgG |
TAB-030ZJ-S(P) | Mouse Anti-IL17A Recombinant Antibody; scFv Fragment (TAB-030ZJ-S(P)) | ELISA, Neut | Mouse scFv |
TAB-030ZJ-F(E) | Mouse Anti-IL17A Recombinant Antibody; Fab Fragment (TAB-030ZJ-F(E)) | ELISA, Neut | Mouse Fab |
CAT | Product Name | Application | Type |
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TAB-078ZJ | Human Anti-IL17A Recombinant Antibody (TAB-078ZJ) | ELISA, Block, Neut | Human antibody |
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TAB-080ZJ | Human Anti-IL17A Recombinant Antibody (TAB-080ZJ) | ELISA, Block, Neut | Human antibody |
TAB-078ZJ-F(E) | Human Anti-IL17A Recombinant Antibody; Fab Fragment (TAB-078ZJ-F(E)) | ELISA, Block, Neut | Human Fab |
PABX-116-S (P) | Recombinant Human Anti-Il-17A Antibody scFv Fragment (CAT-2200) | WB, ELISA, FuncS | scFv |
CAT | Product Name | Application | Type |
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NEUT-1203CQ | Mouse Anti-IL17A Recombinant Antibody (NEUT-1203CQ) | Neut | Mouse IgG1 |
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CAT | Product Name | Application | Type |
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HPAB-0207-LSX-S(P) | Human Anti-IL17A Recombinant Antibody; scFv Fragment (HPAB-0207-LSX-S(P)) | ELISA | Mouse scFv |
HPAB-0208-LSX-S(P) | Mouse Anti-IL17A Recombinant Antibody; scFv Fragment (HPAB-0208-LSX-S(P)) | ELISA | Mouse scFv |
HPAB-0210-LSX-S(P) | Human Anti-IL17A Recombinant Antibody; scFv Fragment (HPAB-0210-LSX-S(P)) | ELISA | Humanized scFv |
HPAB-0211-LSX-S(P) | Rat Anti-IL17A Recombinant Antibody; scFv Fragment (HPAB-0211-LSX-S(P)) | ELISA | Rat scFv |
HPAB-0212-LSX-S(P) | Rat Anti-IL17A Recombinant Antibody; scFv Fragment (HPAB-0212-LSX-S(P)) | ELISA | Rat scFv |
CAT | Product Name | Application | Type |
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HPAB-0207-LSX-F(E) | Human Anti-IL17A Recombinant Antibody; Fab Fragment (HPAB-0207-LSX-F(E)) | ELISA | Human Fab |
HPAB-0208-LSX-F(E) | Human Anti-IL17A Recombinant Antibody; Fab Fragment (HPAB-0208-LSX-F(E)) | ELISA | Human Fab |
HPAB-0209-LSX-F(E) | Human Anti-IL17A Recombinant Antibody; Fab Fragment (HPAB-0209-LSX-F(E)) | ELISA | Chimeric Fab |
HPAB-0210-LSX-F(E) | Human Anti-IL17A Recombinant Antibody; Fab Fragment (HPAB-0210-LSX-F(E)) | ELISA | Humanized Fab |
HPAB-0211-LSX-F(E) | Rat Anti-IL17A Recombinant Antibody; Fab Fragment (HPAB-0211-LSX-F(E)) | ELISA | Rat Fab |
CAT | Product Name | Application | Type |
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NS-042CN | Mouse Anti-IL17A Recombinant Antibody (NS-042CN) | ELISA, FC | Mouse IgG |
NS-042CN-F(E) | Mouse Anti-IL17A Recombinant Antibody; Fab Fragment (NS-042CN-F(E)) | ELISA, FC | Mouse Fab |
NS-042CN-S(P) | Mouse Anti-IL17A Recombinant Antibody; scFv Fragment (NS-042CN-S(P)) | ELISA, FC | Mouse scFv |
CAT | Product Name | Application | Type |
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AFC-TAB-458CQ | Afuco™ Anti-IL17A ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-458CQ) | ELISA, IHC, FC, IP, IF, Inhib | ADCC enhanced antibody |
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AFC-TAB-H08 | Afuco™ Anti-IL17A ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H08) | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
AFC-TAB-H57 | Afuco™ Anti-IL17A ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H57) | ELISA, IP, FC, FuncS, Neut | ADCC enhanced antibody |
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