Anti-IL2 Antibody Prodrug, Protease Activated (VS-1025-YC180)

Name: Anti-IL2 Antibody Prodrug, Protease Activated (VS-1025-YC180)
SKU: VS-1025-YC180
Rating: 5 (1 reviews)

CAT#: VS-1025-YC180

The Anti-IL2 Antibody Prodrug, Protease Activated (VS-1025-YC180) is an antibody prodrug comprised of a recombinant human antibody targeting human IL2, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to IL2 protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to IL2 effectively. IL2 (Interleukin 2) is a key cytokine essential for the proliferation and activation of T-cells and Natural Killer (NK) cells. While it promotes the anti-tumor immune response, it is also used therapeutically in high doses to induce anti-tumor immunity in cancers like melanoma and renal cell carcinoma.

Gene Expression

Normal Tissue Figure 1 Colon

Glandular cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10310/26644_A_7_3.jpg

Normal Tissue Figure 2 Kidney

Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10310/26644_A_8_5.jpg

Normal Tissue Figure 3 Testis

Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10310/26644_A_6_6.jpg

RNA Expression Figure 4 RNA cell line category: Not detected

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000109471-IL2

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Specifications

Host Animal
Human

Applications
In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay

Specificity
Human IL2

Target
IL2

Species Reactivity
Human

Isotype
IgG1

Masking Approach
Affinity mask

Mask
A synthetic peptide

Protease Cleavable Linker
MMP-cleavable linker

Protease Substrate
MMPs

Purification
Protein A purified

Buffer
PBS, pH 7.4

Preservative
No preservatives

Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Target

Introduction
The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.

Alternative Names
IL-2; TCGF; lymphokine

Gene ID
3558

UniProt ID
P60568

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Related Diseases

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Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Datasheet

Datasheet - VS-1025-YC180.pdf

MSDS

MSDS - VS-1025-YC180.pdf

COA

Certificate of Analysis Lookup

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