Recombinant Anti-IL2 Eliminating Antibody, pH-Sensitive (VS-0625-YC175)
CAT#: VS-0625-YC175
The anti-IL2 eliminating antibody is an engineered pH-sensitive antibody against human IL2. IL2, a key cytokine, promotes lymphocyte proliferation and binds receptor complexes for immune regulation. The antibody has a novel IL2-sweeping activity in vivo, which selectively eliminatesthe soluble IL2 from plasma. Compared to conventional antibody, the mAb exerted in vivo efficacy by simultaneously engineering both pH-dependent antigen binding, to mimic the pH-dependent receptor-ligand binding of such endocytic receptors, and increased FcRn binding affinity at neutral pH, to mimic the cell-bound form of the receptors.
Gene Expression
Normal Tissue
Figure 1 Colon
Glandular cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10310/26644_A_7_3.jpg
Normal Tissue
Figure 2 Kidney
Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10310/26644_A_8_5.jpg
Normal Tissue
Figure 3 Testis
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10310/26644_A_6_6.jpg
RNA Expression
Figure 4 RNA cell line category: Not detected
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000109471-IL2
❮
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Specifications
- Host Species
- Human
- Type
- Human IgG1
- Specificity
- Human IL2
- Species Reactivity
- Human
- Applications
- Antigen-Sweeping In Vivo.
Product Property
- Purification
- Protein A/G purified
- Purity
- >95%
- Format
- Liquid
- Buffer
- PBS only
- Preservative
- None
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
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Related Diseases
Autoimmune Thyroid Disease
Maturity Onset Diabetes of the Young
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| CAT | Product Name | Application | Type |
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| TAB-557LC-F(E) | Human Anti-IL2 Recombinant Antibody; Fab Fragment (TAB-557LC-F(E)) | ELISA, FC | Human Fab |
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| TAB-559LC | Mouse Anti-IL2 Recombinant Antibody (TAB-559LC) | ELISA, FC, FuncS | Mouse IgG |
| TAB-559LC-S(P) | Mouse Anti-IL2 Recombinant Antibody; scFv Fragment (TAB-559LC-S(P)) | ELISA, FC | Mouse scFv |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
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| NEUT-1307CQ | Mouse Anti-IL2 Recombinant Antibody (clone 297C16F11) | IHC, Neut | Mouse IgG2a, κ |
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| NEUT-1311CQ | Mouse Anti-IL2 Recombinant Antibody (clone CBL211) | DB, IHC, Neut | Mouse IgG2a, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1309CQ | Mouse Anti-IL2 Recombinant Antibody (VMC195) | FC, Block | Mouse IgG1 |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1801 | Rabbit Anti-IL2 Recombinant Antibody (clone DS1801AB) | ICC, IHC-P, WB | Rabbit IgG |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0112-YC-F(E) | Human Anti-IL2 Recombinant Antibody; Fab Fragment (HPAB-0112-YC-F(E)) | ELISA, FC, FuncS | Human Fab |
| HPAB-3056LY-F(E) | Human Anti-IL2 Recombinant Antibody; Fab Fragment (HPAB-3056LY-F(E)) | ELISA | Human Fab |
| HPAB-3057LY-F(E) | Human Anti-IL2 Recombinant Antibody; Fab Fragment (HPAB-3057LY-F(E)) | ELISA | Human Fab |
| HPAB-3058LY-F(E) | Human Anti-IL2 Recombinant Antibody; Fab Fragment (HPAB-3058LY-F(E)) | ELISA | Human Fab |
| HPAB-3059LY-F(E) | Human Anti-IL2 Recombinant Antibody; Fab Fragment (HPAB-3059LY-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0195CQ-S(P) | Mouse Anti-IL2 Recombinant Antibody (clone LNKB-2); scFv Fragment | WB, IP, IF, ELISA | Mouse scFv |
| HPAB-3056LY-S(P) | Human Anti-IL2 Recombinant Antibody; scFv Fragment (HPAB-3056LY-S(P)) | ELISA | Human scfv |
| HPAB-3057LY-S(P) | Human Anti-IL2 Recombinant Antibody; scFv Fragment (HPAB-3057LY-S(P)) | ELISA | Human scfv |
| HPAB-3058LY-S(P) | Human Anti-IL2 Recombinant Antibody; scFv Fragment (HPAB-3058LY-S(P)) | ELISA | Human scfv |
| HPAB-3059LY-S(P) | Human Anti-IL2 Recombinant Antibody; scFv Fragment (HPAB-3059LY-S(P)) | ELISA | Human scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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