Mouse Anti-Il2 Recombinant Antibody (clone S4B6)

CAT#: PABL-610

Recombinant Mouse Antibody (S4B6) is capable of binding to IL-2, expressed in Chinese Hamster Ovary cells (CHO). This antibody sterically blocked the IL-2:IL-2Rα interaction, while also conformationally stabilizing the IL-2:IL-2Rβ interaction, thus stimulating all IL-2-responsive immune cells, particularly IL-2Rβ(hi) effector cells.

Published Data Gene Expression
Figure 1 Anti-IL-2 antibodies and IL-2 receptor compete for cytokine binding. Figure 2 IL-2Rα expression histograms for Treg cells isolated from treated mouse spleens. Figure 3 Anti-IL-2 antibodies bias cytokine signaling and functional outcomes.
Figure 1 Colon Figure 2 Kidney Figure 3 Testis Figure 4 RNA cell line category: Not detected

Specifications

  • Immunogen
  • Mouse interleukin 2
  • Host Species
  • Mouse
  • Type
  • Mouse IgG
  • Specificity
  • Mouse Il2
  • Species Reactivity
  • Mouse
  • Clone
  • S4B6
  • Applications
  • ELISA, FC, FuncS

Product Property

  • Purity
  • >95% as determined by SDS-PAGE and HPLC analysis
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Applications

  • Application Notes
  • This antibody has been reported for use in Flow Cytometry, Function Assay and Enzyme-Linked Immunosorbent Assay.

Target

  • Alternative Names
  • IL2; interleukin 2; Il-2; interleukin-2; TCGF; T-cell growth factor
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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

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COA

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