Mouse Anti-Il2 Recombinant Antibody (clone S4B6) (CAT#: PABL-610)
Recombinant Mouse Antibody (S4B6) is capable of binding to IL-2, expressed in Chinese Hamster Ovary cells (CHO). This antibody sterically blocked the IL-2:IL-2Rα interaction, while also conformationally stabilizing the IL-2:IL-2Rβ interaction, thus stimulating all IL-2-responsive immune cells, particularly IL-2Rβ(hi) effector cells.
Specific Inquiry
ELISA
Figure 1 Anti-IL-2 antibodies and IL-2 receptor compete for cytokine binding.
Yeast surface mIL-2 competition studies between anti-mIL-2 antibodies (Abs) and saturating concentrations of mIL-2Rα are shown (error bars, SD). Data are representative of three independent experiments.
Spangler, J. B., Tomala, J., Luca, V. C., Jude, K. M., Dong, S., Ring, A. M., ... & Garcia, K. C. (2015). Antibodies to interleukin-2 elicit selective T cell subset potentiation through distinct conformational mechanisms. Immunity, 42(5), 815-825.
FC
Figure 2 IL-2Rα expression histograms for Treg cells isolated from treated mouse spleens.
Representative plots from one mouse per cohort are presented.
Spangler, J. B., Tomala, J., Luca, V. C., Jude, K. M., Dong, S., Ring, A. M., ... & Garcia, K. C. (2015). Antibodies to interleukin-2 elicit selective T cell subset potentiation through distinct conformational mechanisms. Immunity, 42(5), 815-825.
FuncS
Figure 3 Anti-IL-2 antibodies bias cytokine signaling and functional outcomes.
C57BL/6 mouse spleen effector cell: Treg cell ratios after immunocomplex treatment. Data are representative of two independent experiments.
Spangler, J. B., Tomala, J., Luca, V. C., Jude, K. M., Dong, S., Ring, A. M., ... & Garcia, K. C. (2015). Antibodies to interleukin-2 elicit selective T cell subset potentiation through distinct conformational mechanisms. Immunity, 42(5), 815-825.
Specifications
- Immunogen
- Mouse interleukin 2
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Mouse Il2
- Species Reactivity
- Mouse
- Clone
- S4B6
- Applications
- ELISA, FC, FuncS
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Flow Cytometry, Function Assay and Enzyme-Linked Immunosorbent Assay.
Target
- Alternative Names
- IL2; interleukin 2; Il-2; interleukin-2; TCGF; T-cell growth factor
- Gene ID
- 16183
- UniProt ID
- P04351
Related Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1081z | Mouse Anti-IL2 Recombinant Antibody (clone 23B4) | WB, ELISA, FC, FuncS | Mouse IgG1, κ |
| PABL-240 | Mouse Anti-IL2 Recombinant Antibody (clone LNKB-2) | WB, IHC, FuncS | Mouse IgG |
| HPAB-0112-YC | Human Anti-IL2 Recombinant Antibody (HPAB-0112-YC) | WB, ELISA, FC, IHC | Human IgG1 |
| FAMAB-0179YC | Human Anti-IL2 Recombinant Antibody (clone C5) | ELISA, WB | Human IgG |
| FAMAB-0195CQ | Human Anti-IL2 Recombinant Antibody (clone LNKB-2) | WB, IP, IF, ELISA | Chimeric (mouse/human) IgG4, κ |
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABG-093 | Recombinant Anti-Mouse Il2 VHH Single Domain Antibody | ELISA, IHC, FC, FuncS | Llama VHH |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-412CL | Human Anti-IL2 Recombinant Antibody (TAB-412CL) | FuncS | Human IgG1 |
| TAB-556LC | Human Anti-IL2 Recombinant Antibody (TAB-556LC) | ELISA, FC | Humanized antibody |
| TAB-556LC-S(P) | Human Anti-IL2 Recombinant Antibody; scFv Fragment (TAB-556LC-S(P)) | ELISA, FC | Humanized scFv |
| TAB-556LC-F(E) | Human Anti-IL2 Recombinant Antibody; Fab Fragment (TAB-556LC-F(E)) | ELISA, FC | Humanized Fab |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-240 | Mouse Anti-IL2 Recombinant Antibody (clone LNKB-2); Fab Fragment | WB, IHC, FuncS | Mouse Fab |
| HPAB-M0116-YC-F(E) | Mouse Anti-IL2 Recombinant Antibody (clone MAB602); Fab Fragment | ELISA | Mouse Fab |
| HPAB-3056LY-F(E) | Human Anti-IL2 Recombinant Antibody; Fab Fragment (HPAB-3056LY-F(E)) | ELISA | Human Fab |
| HPAB-3057LY-F(E) | Human Anti-IL2 Recombinant Antibody; Fab Fragment (HPAB-3057LY-F(E)) | ELISA | Human Fab |
| HPAB-3058LY-F(E) | Human Anti-IL2 Recombinant Antibody; Fab Fragment (HPAB-3058LY-F(E)) | ELISA | Human Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-604 | Mouse Anti-Il2 Recombinant Antibody (clone JES6-1); scFv Fragment | Neut | Mouse scFv |
| FAMAB-0179-YC-S(P) | Human Anti-IL2 Recombinant Antibody (clone C5); scFv Fragment | ELISA, WB | Human scFv |
| FAMAB-0195CQ-S(P) | Mouse Anti-IL2 Recombinant Antibody (clone LNKB-2); scFv Fragment | WB, IP, IF, ELISA | Mouse scFv |
| PSBC-506 | Human Anti-IL2 Recombinant Antibody (clone F5111.2); scFv Fragment | ELISA, FC, FuncS | Human scFv |
| HPAB-M0116-YC-S(P) | Mouse Anti-IL2 Recombinant Antibody (clone MAB602); scFv Fragment | ELISA | Mouse scFv |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-557LC | Human Anti-IL2 Recombinant Antibody (TAB-557LC) | ELISA, FC, Inhib, FuncS | Human IgG1 |
| TAB-557LC-S(P) | Human Anti-IL2 Recombinant Antibody; scFv Fragment (TAB-557LC-S(P)) | ELISA, FC | Human scFv |
| TAB-558LC-S(P) | Human Anti-IL2 Recombinant Antibody; scFv Fragment (TAB-558LC-S(P)) | ELISA, FC | Human scFv |
| TAB-557LC-F(E) | Human Anti-IL2 Recombinant Antibody; Fab Fragment (TAB-557LC-F(E)) | ELISA, FC | Human Fab |
| TAB-558LC-F(E) | Human Anti-IL2 Recombinant Antibody; Fab Fragment (TAB-558LC-F(E)) | ELISA, FC | Human Fab |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-559LC | Mouse Anti-IL2 Recombinant Antibody (TAB-559LC) | ELISA, FC, FuncS | Mouse IgG |
| TAB-559LC-S(P) | Mouse Anti-IL2 Recombinant Antibody; scFv Fragment (TAB-559LC-S(P)) | ELISA, FC | Mouse scFv |
| TAB-559LC-F(E) | Mouse Anti-IL2 Recombinant Antibody; Fab Fragment (TAB-559LC-F(E)) | ELISA, FC | Mouse Fab |
| PABX-123 | Recombinant Mouse Anti-Interleukin 2 Antibody | WB, ELISA, Neut, FuncS | IgG |
| PABX-123-F (E) | Recombinant Mouse Anti-Interleukin 2 Antibody Fab Fragment | WB, ELISA, Neut, FuncS | Fab |
Deglycosylated Antibody (Non-glycosylated IgGs)
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-182LC | Recombinant Anti-Human IL2 Antibody (Non-glycosylated) | ELISA | Human antibody |
| Gly-183LC | Recombinant Anti-Human IL2 Antibody (Non-glycosylated) | ELISA | Human antibody |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0283MZ | Chicken Anti-Interleukin-2 Polyclonal IgY | WB, Indirect ELISA | Chicken antibody |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1306CQ | Rat Anti-IL2 Recombinant Antibody (clone 17H12) | Neut | Rat IgG2a |
| NEUT-1307CQ | Mouse Anti-IL2 Recombinant Antibody (clone 297C16F11) | IHC, Neut | Mouse IgG2a, κ |
| NEUT-1308CQ | Mouse Anti-IL2 Recombinant Antibody (VMC194) | FuncS, Neut | Mouse IgG2a, κ |
| NEUT-1310CQ | Mouse Anti-IL2 Recombinant Antibody (clone CBL121) | Neut, WB, IHC | Mouse IgG1 |
| NEUT-1311CQ | Mouse Anti-IL2 Recombinant Antibody (clone CBL211) | DB, IHC, Neut | Mouse IgG2a, κ |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1309CQ | Mouse Anti-IL2 Recombinant Antibody (VMC195) | FC, Block | Mouse IgG1 |
| NEUT-1315CQ | Rat Anti-Il2 Recombinant Antibody (clone 1A12), Biotin | Block, ELISA, WB | Rat IgG2a |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1801 | Rabbit Anti-IL2 Recombinant Antibody (clone DS1801AB) | ICC, IHC-P, WB | Rabbit IgG |
| MOR-4612 | Rabbit Anti-IL2 Recombinant Antibody (clone TH125DS) | WB, IHC-P | Rabbit IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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