Rabbit Anti-ITGA5 Recombinant Antibody (VS3-CJ513)
CAT#: VS3-CJ513
This product is a rabbit antibody that recognizes human, mouse, and rat ITGA5.
Gene Expression
Normal Tissue
Figure 1 High expression in placenta
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2642/ihc_selected.jpg
Normal Tissue
Figure 2 Low expression in skeletal muscle
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2642/10675_B_1_6_val_selected.jpg
Normal Tissue
Figure 3 IHC staining of human placenta
Immunohistochemical staining of human placenta shows distinct cytoplasmic positivity in trophoblastic cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9008/ihc_selected.jpg
Normal Tissue
Figure 4 Liver
Hepatocytes Staining: Low Intensity: Moderate
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2642/10675_A_8_4.jpg
Normal Tissue
Figure 5 Placenta
Endothelial cells Staining: High Intensity: Strong Quantity: 75%-25% Hofbauer cells Staining: Low Intensity: Moderate Quantity: <25% Syncytiotrophoblasts - cell body Staining: High Intensity: Strong Quantity:>75% Syncytiotrophoblasts - microvilli Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2642/10675_A_3_7.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (hTERT-RPE1, HUVEC TERT2, TIME, U-87 MG)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000161638-ITGA5
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Specifications
- Immunogen
- Recombinant protein
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse, Rat ITGA5
- Species Reactivity
- Human, Mouse, Rat
- Applications
- WB, ICC, IF, IHC, IP, FC
- Conjugate
- Unconjugated
Product Property
- Purification
- Protein A affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- 40% Glycerol, 1% BSA, TBS, pH7.4.
- Preservative
- 0.05% Sodium Azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Western Blot, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Flow Cytometry.
Target
- Alternative Names
- FNRA; CD49e; VLA-5; VLA5A
- Gene ID
- 3678
- UniProt ID
- P08648
- Sequence Similarities
- Belongs to the integrin alpha chain family.
- Cellular Localization
- Cell junction, Membrane
- Post Translation Modifications
- Proteolytic cleavage by PCSK5 mediates activation of the precursor.
- Protein Refseq
- NP_002196.4
- Function
- Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877).
ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881).
ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430).
ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (PubMed:31331973).
(Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human metapneumovirus.
(Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human parvovirus B19.
(Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "ITGA5"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-077 | Anti-Human Integrin alpha 5 beta 1 Recombinant Antibody (Volociximab) | ELISA, IHC | IgG4 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1554CQ | Recombinant Mouse Anti-ITGA5 Antibody (NKI-SAM-1) | FC, IP, ELISA, BL | IgG2b, κ |
| NEUT-1555CQ | Recombinant Armenian Hamster Anti-Itga5 Antibody (HMα5-1) | FC, BL, IP | IgG |
| NEUT-1556CQ | Recombinant Rat Anti-Itga5 Antibody (5H10-27) | FC, BL, IHC-Fr, FuncS | IgG2a, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1874 | Hi-Affi™ Recombinant Rabbit Anti-ITGA5 Monoclonal Antibody (DS1874AB) | WB, IHC-P, ICC, IF, IP, FC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-077 | Afuco™ Anti-ITGA5 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-077) | IP, IF, FuncS, FC, Neut, ELISA | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0398-WJ | Human Anti-ITGA5 Recombinant Antibody (HPAB-0398-WJ) | ELISA | Humanized IgG |
| HPAB-0399-WJ | Mouse Anti-ITGA5 Recombinant Antibody (HPAB-0399-WJ) | FC | Mouse IgG |
| VS3-QX607 | Mouse Anti-ITGA5 Recombinant Antibody (clone 10F6) | WB, IHC, ICC, FC, ELISA | Mouse IgG2a |
| VS7-0425-WR154 | Mouse Anti-ITGA5 Monoclonal Antibody (VS7-0425-WR154) | WB, IHC-P, IF, FC, ELISA | Mouse IgG |
| VS7-0425-WR155 | Mouse Anti-ITGA5 Recombinant Antibody (VS7-0425-WR155) | WB, FC | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0398-WJ-S(P) | Human Anti-ITGA5 Recombinant Antibody; scFv Fragment (HPAB-0398-WJ-S(P)) | ELISA | Humanized scFv |
| HPAB-0399-WJ-S(P) | Mouse Anti-ITGA5 Recombinant Antibody; scFv Fragment (HPAB-0399-WJ-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0398-WJ-F(E) | Human Anti-ITGA5 Recombinant Antibody; Fab Fragment (HPAB-0398-WJ-F(E)) | ELISA | Humanized Fab |
| HPAB-0399-WJ-F(E) | Mouse Anti-ITGA5 Recombinant Antibody; Fab Fragment (HPAB-0399-WJ-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC1485 | AbPlus™ Anti-ITGA5 Magnetic Beads (VS-0724-YC1485) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1155 | Anti-ITGA5 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3627 | Anti-Mouse ITGA5 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3629 | Anti-Human ITGA5 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3628 | Anti-Rat ITGA5 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY136 | Rabbit Anti-ITGA5 scFv-Fc Chimera (VS-0425-FY136) | ELISA, Flow, ICC, IF, IHC, BLOCK | Rabbit IgG, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC570 | Recombinant Anti-ITGA5 Vesicular Antibody, EV Displayed (VS-0425-YC570) | ELISA, FC, Cell-uptake |
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