AibGenesis™ Rabbit Anti-ITGAV Recombinant Antibody (AibG-Rb-AV221)
CAT#: VS14-YC422
This AI-modeled antibody is specifically engineered for high-affinity targeting of ITGAV across human, mouse, and rat. ITGAV (Integrin Alpha V, CD51) is a versatile transmembrane receptor subunit that heterodimerizes with various beta subunits (e.g., beta 1, beta 3, beta 5, beta 6, beta 8) to mediate cell-matrix adhesion and bidirectional "inside-out" and "outside-in" signaling. It acts as a primary mechanical transducer that activates the FAK/Src and PI3K/Akt signaling pathways, and plays a specialized role in the TGF-beta activation cascade by exerting physical force on the latent TGF-beta complex.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to cytosol & focal adhesion sites.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4856/if_selected.jpg
Subcellular Location
Figure 2 IHC staining of human placenta
Immunohistochemical staining of human placenta shows strong cytoplasmic and membranous positivity in trophoblastic cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4856/ihc_selected.jpg
Subcellular Location
Figure 3 IHC staining of human urinary bladder
Immunohistochemical staining of human urinary bladder shows strong membranous positivity in urothelial cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2499/ihc_selected.jpg
Subcellular Location
Figure 4 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol & focal adhesion sites.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4856/10_E3_1_blue_red_green.jpg
Subcellular Location
Figure 5 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to cytosol & focal adhesion sites.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4856/15_E3_1_blue_red_green.jpg
Normal Tissue
Figure 6 Cerebral cortex
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2499/6125_B_8_5.jpg
Normal Tissue
Figure 7 Colon
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Glandular cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2499/6125_A_9_3.jpg
Normal Tissue
Figure 8 Liver
Cholangiocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2499/6125_A_9_4.jpg
Normal Tissue
Figure 9 Placenta
Cytotrophoblasts
Staining: High
Intensity: Strong
Quantity:>75%
Endothelial cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Syncytiotrophoblasts - cell body
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Syncytiotrophoblasts - microvilli
Staining: High
Intensity: Strong
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2499/6125_A_2_7.jpg
RNA Expression
Figure 10 RNA cell line category: Cell line enhanced (RT4, SuSa)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000138448-ITGAV
❮
❯
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- ITGAV
- Species Reactivity
- Human, Mouse, Rat
- Clone
- AibG-Rb-AV221
- Applications
- Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity purified
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% Glycerol
- Preservative
- 0.02% Sodium azide
- Storage
- Store at 4˚C short term. Aliquot and store at -20˚C long term. Avoid freeze/thaw cycles.
Applications
- Application Notes
- Western Blot (WB): 1/500-1/2000
Immunohistochemistry (IHC): 1/50-1/200
Immunocytochemistry (ICC): 1/50-1/200
Immunofluorescence (IF): 1/50-1/200
Target
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS14-YC422. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "ITGAV"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1133z | Mouse Anti-ITGAV Recombinant Antibody (clone 33D12) | ELISA, ICC, IF, IHC, IP, FuncS | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-076 | Anti-Human CD51 Recombinant Antibody (TAB-076) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG1 - kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H01 | Anti-Human ITGAV Recombinant Antibody (Abituzumab) | Inhib, Agonist | IgG2 - kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-250 | Mouse Anti-ITGAV Recombinant Antibody (clone 17E6) | WB, ELISA, FuncS | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-250 | Mouse Anti-ITGAV Recombinant Antibody (clone 17E6); scFv Fragment | WB, ELISA, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-250 | Mouse Anti-ITGAV Recombinant Antibody (clone 17E6); Fab Fragment | WB, ELISA, FuncS | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0242CT | Recombinant Mouse anti-Human ITGAV Monoclonal antibody (24D3) | FC, IHC-Fr, PP |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-191-S (P) | Recombinant Mouse Anti-αVβ3 Ectodomain Antibody scFv Fragment (17E6) | Neut, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-191-F (E) | Recombinant Mouse Anti-αVβ3 Ectodomain Antibody Fab Fragment (17E6) | Neut, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1537CQ | Recombinant Mouse Anti-ITGAV Antibody (272-17E6) | Inhib, ICC, IF, BL, FC, ELISA, IP | IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1577CQ | Recombinant Mouse Anti-ITGAV Antibody (13C2) | FC, IHC-Fr, ICC, IP, ELISA, Depletion, BL, Adhesion | IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1578CQ | Recombinant Mouse Anti-ITGAV Antibody (NKI-M9) | FC, IF, ELISA, BL, IP | IgG2a, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1579CQ | Recombinant Mouse Anti-ITGAV Antibody (10D5) | IP, FC, BL | IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1580CQ | Recombinant Mouse Anti-ITGAV Antibody (27.1) | ICC, IF, FC, IP, IHC-Fr, BL | IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1582CQ | Recombinant Rat Anti-Itgav Antibody (RMV-7) | FC, FuncS, IP, Neut | IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1880 | Hi-Affi™ Recombinant Rabbit Anti-ITGAV Monoclonal Antibody (DS1880AB) | WB, FC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-0852-CN | Recombinant Rabbit Anti-ITGAV Monoclonal Antibody (CBACN-313) | WB, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-076 | Afuco™ Anti-ITGAV ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-076) | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-H01 | Afuco™ Anti-ITGAV ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H01) | ELISA, IP, FC, FuncS, IF, Neut | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1767-FY | Human Anti-EPHA2 Recombinant Antibody (clone 12G3) | ADCC | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1767-FY-F(E) | Human Anti-EPHA2 Recombinant Antibody (clone 12G3); Fab Fragment | Cyt, ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1767-FY-S(P) | Human Anti-EPHA2 Recombinant Antibody (clone 12G3); scFv Fragment | Cyt, ELISA | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY160 | AbPlus™ Anti-ITGAV Magnetic Beads (13C2) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC600 | CytoStream™ Rabbit Anti-ITGAV Recombinant Antibody (VS13-YC600) | WB, ICC, IF, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY88 | Human Anti-ITGAV scFv-Fc Chimera (VS-0425-FY88) | ELISA, FC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC298 | Recombinant Anti-ITGAV Vesicular Antibody, EV Displayed (VS-0425-YC298) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3644 | Anti-ITGAV Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3645 | Anti-Rat ITGAV Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3646 | Anti-Mouse ITGAV Immunohistochemistry Kit | IHC |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: FC, Cyt, Stim, PP, Agonist
-2.png)
Application: FuncS, IF, Neut, ELISA, FC, IP, ICC
Application: WB, ELISA, FC, IP, FuncS, IF, Neut
Application: FC, IP, ELISA, Neut, FuncS, IF, WB
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: IF, IP, Neut, FuncS, ELISA, FC, WB
Application: Neut, ELISA, IF, IP, FuncS, FC, WB
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: FuncS, IF, Neut, ELISA, FC, IP, ICC
Application: FC, IP, ELISA, Neut, FuncS, IF, ICC
Application: WB, IHC, FC, Cyt, ELISA
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
