Monkey Anti-MOG Recombinant Antibody (clone M3-24) (CAT#: FAMAB-0229JF)

Recombinant monoclonal antibody specially binds to myelin oligodendrocyte glycoprotein (MOG). This monkey anti-MOG antibody (M3-24) can be useful to study autoreactive humoral immune responses against central nervous system (CNS) myelin antigens in multiple sclerosis (MS).


Specific Inquiry
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  • Published Data
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
IHC

Figure 1 Brain and cerebellum nonhuman primate myelin staining with commercial monoclonal MOG.

Figure 1 Brain and cerebellum nonhuman primate myelin staining with commercial monoclonal MOG.

Purified IgG-AF594 from patients colocalized with commercial anti-MBP.

Cobo-Calvo, A., Ayrignac, X., Kerschen, P., Horellou, P., Cotton, F., Labauge, P., ... & Marignier, R. (2019). Cranial nerve involvement in patients with MOG antibody–associated disease. Neurology-Neuroimmunology Neuroinflammation, 6(2).

ELISA

Figure 2 Comparison of sensitivity between avidin-biotin ELISA (filled circles) and conventional ELISA (open circles) for detection of IgG in human normal sera.

Figure 2 Comparison of sensitivity between avidin-biotin ELISA (filled circles) and conventional ELISA (open circles) for detection of IgG in human normal sera.

Arrows indicate mean amount of IgG detected when the OD at 405 nm is 0.1.

Lackner, P., Kuenz, B., Reindl, M., Morandell, M., Berger, T., Schmutzhard, E., & Eggers, C. (2010). Antibodies to myelin oligodendrocyte glycoprotein in HIV-1 associated neurocognitive disorder: a cross-sectional cohort study. Journal of neuroinflammation, 7(1), 79.

WB

Figure 3 Specific staining of anti-MOG IgG antibodies by Western blot.

Figure 3 Specific staining of anti-MOG IgG antibodies by Western blot.

Arrows indicate immunostaining bands.

Lackner, P., Kuenz, B., Reindl, M., Morandell, M., Berger, T., Schmutzhard, E., & Eggers, C. (2010). Antibodies to myelin oligodendrocyte glycoprotein in HIV-1 associated neurocognitive disorder: a cross-sectional cohort study. Journal of neuroinflammation, 7(1), 79.


Specifications

  • Immunogen
  • Recombinant protein corresponding to the extracellular domain of rat MOGaa1-125
  • Host Species
  • Monkey
  • Derivation
  • C. jacchus marmosets phage display Fab library
  • Type
  • Monkey Fab
  • Specificity
  • Rat MOG
  • Species Reactivity
  • Rat
  • Clone
  • M3-24
  • Applications
  • WB, ELISA, IHC
  • Related Disease
  • Multiple sclerosis

Product Property

  • Purity
  • >95% as determined by SDS-PAGE and HPLC analysis
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Buffer
  • PBS
  • Preservative
  • No preservatives
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Applications

  • Application Notes
  • The MOG antibody has been reported in applications of Western Blot, Enzyme-linked Immunosorbent Assay, Immunohistochemistry.

Target

  • Alternative Names
  • MOG; myelin oligodendrocyte glycoprotein

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

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Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-2266 Hi-Affi™ Recombinant Rabbit Anti-MOG Monoclonal Antibody (DS2266AB) WB, IHC, ICC IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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