Anti-MYC Antibody Prodrug, Protease Activated (CT14)
CAT#: VS-1025-YC55
The Anti-MYC Antibody Prodrug, Protease Activated (CT14) is an antibody prodrug comprised of a recombinant mouse antibody targeting human MYC, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to MYC protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to MYC effectively. MYC is a transcription factor and one of the most powerful and frequently activated proto-oncogenes in human cancer. It is often overexpressed via gene amplification or translocation. Uncontrolled MYC expression drives a pro-proliferative program by globally regulating the transcription of genes involved in cell growth, metabolism, and division.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55893/if_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IF staining of human cell line SK-MEL-30
Immunofluorescent staining of human cell line SK-MEL-30 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/66556/1279_E11_3_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IHC staining of human cerebellum
Immunohistochemical staining of human cerebellum shows moderate nucleolar positivity in Purkinje cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55893/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 4 IHC staining of human rectum
Immunohistochemical staining of human rectum shows moderate nuclear and cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/84/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 5 IHC staining of human caudate
Immunohistochemical staining of human caudate shows distinct nucleolar positivity in neuronal cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10307/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 6 IF staining of human cell line PC-3
Immunofluorescent staining of human cell line PC-3 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55893/883_H10_1_red_green.jpg
Subcellular Location and Protein Expression
Figure 7 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55893/879_G9_1_red_green.jpg
Normal Tissue
Figure 8 Cerebral cortex
Neuronal cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10307/30810_B_7_5.jpg
Normal Tissue
Figure 9 Liver
Hepatocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10307/30810_A_9_4.jpg
Normal Tissue
Figure 10 Kidney
Cells in glomeruli
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10307/30810_A_7_5.jpg
Normal Tissue
Figure 11 Cervix
Squamous epithelial cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10307/30810_B_8_3.jpg
Normal Tissue
Figure 12 Lymph node
Non-germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10307/30810_A_9_8.jpg
RNA Expression
Figure 13 RNA cell line category: Cell line enhanced (RPMI-8226)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000136997-MYC
❮
❯
Specifications
- Host Animal
- Mouse
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human MYC
- Target
- MYC
- Species Reactivity
- Human
- Isotype
- IgG2a
- Clone
- CT14
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein A purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.
- Alternative Names
- MRTL; MYCC; c-Myc; bHLHe39
- Gene ID
- 4609
- UniProt ID
- P01106
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Related Signaling Pathways
BCR Signaling Pathway
Related Diseases
Bladder Cancer
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Datasheet
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See other products for "Clone CT14"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-281 | Mouse Anti-MYC Recombinant Antibody (clone 9E10) | WB, IHC, FuncS | Mouse IgG |
| MOB-0268CT | Recombinant Mouse anti-Human MYC Monoclonal antibody (4H40) | ELISA, ICC, IF, IHC-P, IP, WB | |
| FAMAB-0112-CN | Mouse Anti-MYC Recombinant Antibody (clone CT14) | ELISA, WB, FC, Inhib | Mouse IgG2a |
| MRO-1778-CN | Rabbit Anti-MYC Polyclonal Antibody (MRO-1778-CN) | WB | Rabbit IgG |
| MRO-1779-CN | Rabbit Anti-MYC Polyclonal Antibody (MRO-1779-CN) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-281 | Mouse Anti-MYC Recombinant Antibody (clone 9E10); scFv Fragment | WB, IHC, FuncS | Mouse scFv |
| FAMAB-0112-CN-S(P) | Mouse Anti-MYC Recombinant Antibody (clone CT14); scFv Fragment | ELISA, WB, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-281 | Mouse Anti-MYC Recombinant Antibody (clone 9E10); Fab Fragment | WB, IHC, FuncS | Mouse Fab |
| FAMAB-0112-CN-F(E) | Mouse Anti-MYC Recombinant Antibody (clone CT14); Fab Fragment | ELISA, WB, FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0400MC | Anti-c-Myc antibody (HRP) | ELISA, IHC-P, IHC-Fr, WB |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0380MZ | Chicken Anti-c-Myc (ab1) Polyclonal IgY | Indirect ELISA, WB | Chicken antibody |
| BRD-0381MZ | Chicken Anti-c-Myc (ab2) Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2336 | Hi-Affi™ Recombinant Rabbit Anti-MYC Monoclonal Antibody (DS2336AB) | WB, IP, ICC | IgG |
| MOR-4554 | Hi-Affi™ Recombinant Rabbit Anti-MYC Monoclonal Antibody (TH64DS) | WB, IF, ICC, FC | IgG |
| MOR-0050-FY | Rabbit Anti-MYC Recombinant Antibody (clone AFY0021) | ICC, IHC, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY194 | AbPlus™ Anti-MYC Magnetic Beads (33) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY133 | Mouse Anti-NHP MYC Recombinant Antibody (clone MYC699) | IF, FC, ELISA | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4607 | Anti-MYC Immunohistochemistry Kit | IHC | |
| VS-0525-XY4608 | Anti-Human MYC Immunohistochemistry Kit | IHC | |
| VS-0525-XY4609 | Anti-Mouse MYC Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0825-YC263 | SmartAb™ Recombinant Anti-MYC pH-dependent Antibody (Clone CT14) | ELISA, WB, FC, Inhib | Mouse IgG2a |
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