Recombinant Mouse anti-Human MYC Monoclonal antibody (4H40)
CAT#: MOB-0268CT
Recombinant mouse monoclonal antibody to human MYC, expressed in Chinese Hamster Ovary cells(CHO). This antibody recognizes proteins tagged with c-myc at either the C-terminus or the N-terminus as well as Human c-Myc protein. The immunogen of this product is a synthetic peptide corresponding to amino acids 408-439 of human c-Myc.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55893/if_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IF staining of human cell line SK-MEL-30
Immunofluorescent staining of human cell line SK-MEL-30 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/66556/1279_E11_3_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IHC staining of human cerebellum
Immunohistochemical staining of human cerebellum shows moderate nucleolar positivity in Purkinje cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55893/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 4 IHC staining of human rectum
Immunohistochemical staining of human rectum shows moderate nuclear and cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/84/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 5 IHC staining of human caudate
Immunohistochemical staining of human caudate shows distinct nucleolar positivity in neuronal cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10307/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 6 IF staining of human cell line PC-3
Immunofluorescent staining of human cell line PC-3 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55893/883_H10_1_red_green.jpg
Subcellular Location and Protein Expression
Figure 7 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55893/879_G9_1_red_green.jpg
Normal Tissue
Figure 8 Cerebral cortex
Neuronal cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10307/30810_B_7_5.jpg
Normal Tissue
Figure 9 Liver
Hepatocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10307/30810_A_9_4.jpg
Normal Tissue
Figure 10 Kidney
Cells in glomeruli
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10307/30810_A_7_5.jpg
Normal Tissue
Figure 11 Cervix
Squamous epithelial cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10307/30810_B_8_3.jpg
Normal Tissue
Figure 12 Lymph node
Non-germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10307/30810_A_9_8.jpg
RNA Expression
Figure 13 RNA cell line category: Cell line enhanced (RPMI-8226)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000136997-MYC
❮
❯
Specifications
- Immunogen
- Synthetic peptide corresponding to amino acids 408-439 of human c-Myc.
- Host Species
- Mouse
- Specificity
- This antibody recognizes proteins tagged with c-myc at either the C-terminus or the N-terminus as well as Human c-Myc protein.
- Species Reactivity
- Human
- Clone
- 4H40
- Applications
- Used for immunoassay techniques such as: Enzyme-linked Immunosorbent Assay; Immunocytochemistry/Immunofluorescence; Immunohistochemistry paraffin embedded sections; Immunoprecipitation; Western Blot
- Conjugate
- FITC
Product Property
- Purity
- Protein A purified
- Format
- Liquid
- Concentration
- 0.5 mg/ml
- Buffer
- Preservative: 0.05% Sodium Azide Constituents: 50% Glycerol, 1% BSA, PBS, pH 7.4
- Storage
- Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Target
- Alternative Names
- MYC; v-myc avian myelocytomatosis viral oncogene homolog; MRTL; MYCC; c-Myc; bHLHe39; myc proto-oncogene protein; proto-oncogene c-Myc; transcription factor p64; class E basic helix-loop-helix protein 39; avian myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene homolog; myc-related translation/localization regulatory factor;
- Gene ID
- 4609
- UniProt ID
- P01106
- Protein Refseq
- NP_002458
- Function
- DNA binding; E-box binding; protein binding; sequence-specific DNA binding transcription factor activity;
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Related Signaling Pathways
BCR Signaling Pathway
Related Diseases
Bladder Cancer
Breast Cancer
Colorectal Cancer
Gastric Cancer
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
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| CAT | Product Name | Application | Type |
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| PFBL-281 | Mouse Anti-MYC Recombinant Antibody (clone 9E10); Fab Fragment | WB, IHC, FuncS | Mouse Fab |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| MOR-2336 | Hi-Affi™ Recombinant Rabbit Anti-MYC Monoclonal Antibody (DS2336AB) | WB, IP, ICC | IgG |
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| MOR-0050-FY | Rabbit Anti-MYC Recombinant Antibody (clone AFY0021) | ICC, IHC, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0112-CN | Mouse Anti-MYC Recombinant Antibody (clone CT14) | ELISA, WB, FC, Inhib | Mouse IgG2a |
| MRO-1778-CN | Rabbit Anti-MYC Polyclonal Antibody (MRO-1778-CN) | WB | Rabbit IgG |
| MRO-1779-CN | Rabbit Anti-MYC Polyclonal Antibody (MRO-1779-CN) | WB | Rabbit IgG |
| ZG-0258U | Mouse Anti-MYC Recombinant Antibody (clone 5H5G5) | ELISA, WB | Mouse IgG1 |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4607 | Anti-MYC Immunohistochemistry Kit | IHC | |
| VS-0525-XY4608 | Anti-Human MYC Immunohistochemistry Kit | IHC | |
| VS-0525-XY4609 | Anti-Mouse MYC Immunohistochemistry Kit | IHC |
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