Human Anti-NTRK2 Recombinant Antibody (clone 4B12-15); Fab Fragment (CAT#: HPAB-AP765-YC-F(E))
Provided are TrkB agonist antibodies, which can be used in the treatment of peripheral neuropathies, such as Charcot-Marie-Tooth disease. The antibody can be used for immunoassay techniques such as: Function Assay as a agonist.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7637/202_C1_1_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7637/202_C1_1_selected.jpg
Figure 2 High expression in cerebral cortex
(Neuronal cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10346/162989_B_7_5.jpg
(Neuronal cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10346/162989_B_7_5.jpg
Figure 3 Kidney
(Cells in tubules Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10346/162989_A_8_5.jpg
(Cells in tubules Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10346/162989_A_8_5.jpg
Figure 4 Testis
(Leydig cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10346/162989_A_6_6.jpg
(Leydig cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/10346/162989_A_6_6.jpg
Figure 5 RNA cell line category: Cell line enhanced (AF22, HaCaT, RPTEC TERT1, SH-SY5Y, SuSa)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000148053-NTRK2
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000148053-NTRK2
Specifications
- Host Species
- Human
- Derivation
- Humanized
- Type
- Humanized Fab
- Specificity
- Human NTRK2
- Species Reactivity
- Human
- Clone
- 4B12-15
- Applications
- Agonist
- Related Disease
- Charcot-Marie-Tooth disease
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Neurotrophic Receptor Tyrosine Kinase 2; Neurotrophic Tyrosine Kinase Receptor Type 2; Tropomyosin-Related Kinase B; EC 2.7.10.1; GP145-TrkB; Trk-B; TRKB; Neurotrophic Tyrosine Kinase, Receptor, Type 2
- Gene ID
- 4915
- UniProt ID
- Q16620
Related Resources
EGFR Tyrosine Kinase Inhibitor Resistance
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-179CQ | Anti-Human NTRK2 Recombinant Antibody (RN1026A) | ELISA, FC | Humanized antibody |
| TAB-177CQ-S(P) | Anti-Human NTRK2 Recombinant Antibody scFv Fragment (C2) | ELISA, FC | Humanized antibody |
| TAB-177CQ-F(E) | Anti-Human NTRK2 Recombinant Antibody Fab Fragment (C2) | ELISA, FC | Humanized antibody |
| TAB-178CQ-F(E) | Anti-Human NTRK2 Recombinant Antibody Fab Fragment (A2) | ELISA, FC | Humanized antibody |
| TAB-179CQ-F(E) | Anti-Human NTRK2 Recombinant Antibody Fab Fragment (RN1026A) | ELISA, FC | Humanized antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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