Human Anti-NTRK2 Recombinant Antibody (clone 4A6) (CAT#: HPAB-AP761-YC)
Provided are TrkB agonist antibodies, which can be used in the treatment of peripheral neuropathies, such as Charcot-Marie-Tooth disease. The antibody can be used for immunoassay techniques such as: Function Assay as a agonist.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
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FuncS
Figure 1 The relative amount of neuron survival in the presence of increasing amounts of several agonist anti-TrkB humanized antibodies using an in vitro assay.
Top graph: agonist anti-TrkB humanized antibodies C1, C2, 4A6 and 4B12. Bottom graph: various isotype forms of agonist anti-TrkB humanized antibody RN1026A (1026A). Mouse monoclonal agonist anti-TrkB antibody 38B8 and/or BDNF are used positive controls. The y-axis indicates the number of neurons, and x-axis indicates the concentration of antibody (or BDNF) in pM.
Specifications
- Host Species
- Human
- Derivation
- Humanized
- Type
- Humanized IgG
- Specificity
- Human NTRK2
- Species Reactivity
- Human, Mouse, Rat
- Clone
- 4A6
- Applications
- FuncS
- Related Disease
- Charcot-Marie-Tooth disease
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Functional Assay.
Target
- Alternative Names
- Neurotrophic Receptor Tyrosine Kinase 2; Neurotrophic Tyrosine Kinase Receptor Type 2; Tropomyosin-Related Kinase B; EC 2.7.10.1; GP145-TrkB; Trk-B; TRKB; Neurotrophic Tyrosine Kinase, Receptor, Type 2
- Gene ID
- 4915
- UniProt ID
- Q16620
Related Resources
EGFR Tyrosine Kinase Inhibitor Resistance
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Human Antibody Products
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ScFv Antibody Products
ScFv-Fc Chimera Products
Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-180CQ | Anti-Human NTRK2 Recombinant Antibody (C20) | FuncS | Human antibody |
| TAB-180CQ-S(P) | Anti-Human NTRK2 Recombinant Antibody scFv Fragment (C20) | ELISA, FC, WB | Human antibody |
| TAB-180CQ-F(E) | Anti-Human NTRK2 Recombinant Antibody Fab Fragment (C20) | ELISA, FC, WB | Human antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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