Mouse Anti-NTRK2 Recombinant Antibody (clone 8D2E8)
CAT#: VS7-0425-WR512
This product is a mouse IgG1 antibody that binds to human NTRK2. The antibody 8D2E8 recognizes specific amino acid domain of human NTRK2 (AA: 207-339). It can be used for WB and ELISA assays.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7637/202_C1_1_selected.jpg
Normal Tissue
Figure 2 High expression in cerebral cortex
Neuronal cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10346/162989_B_7_5.jpg
Normal Tissue
Figure 3 Kidney
Cells in tubules Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10346/162989_A_8_5.jpg
Normal Tissue
Figure 4 Testis
Leydig cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10346/162989_A_6_6.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (AF22, HaCaT, RPTEC TERT1, SH-SY5Y, SuSa)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000148053-NTRK2
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Specifications
- Immunogen
- Recombinant human NTRK2 (AA: 207-339) fragment expressed in E. Coli.
- Host Species
- Mouse
- Type
- Mouse IgG1
- Specificity
- Human NTRK2
- Species Reactivity
- Human
- Clone
- 8D2E8
- Molecule Class
- Neurotrophic Tyrosine Kinase Receptor (NTKR) Family
- Applications
- WB, ELISA
- Conjugate
- Unconjugated
- Related Disease
- Developmental and epileptic encephalopathy 58 (DEE58); Obesity, hyperphagia, and developmental delay (OBHD)
Product Property
- Clonality
- Monoclonal
- Purity
- >95% as determined by SDS-PAGE and SEC-HPLC analysis
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- 0.05% sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Western Blot: 1:500 - 1:2000
Enzyme-linked Immunosorbent Assay: 1:10000
Target
- Alternative Names
- NTRK2; Tyrosine Kinase Receptor B; Tropomyosin-Related Kinase B; EC 2.7.10; Trk-B; TrkB Tyrosine Kinase; EC 2.7.10.1; GP145-TrkB; Neurotrophic Tyrosine Kinase, Receptor, Type 2; TRKB; BDNF/NT-3 Growth Factors Receptor; Neurotrophic Tyrosine Kinase Recepto
- Gene ID
- 4915
- UniProt ID
- Q16620
- Long Name
- Neurotrophic Receptor Tyrosine Kinase 2
- Cellular Localization
- Cell membrane; Cell projection; Cytoplasm; Endosome; Membrane; Synapse
- Post Translation Modifications
- Disulfide bond; Glycoprotein; Phosphoprotein; Ubl conjugation
- Protein Refseq
- NP_001007098.1
- Function
- Developmental protein; Kinase; Receptor; Transferase; Tyrosine-protein kinase
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Related Diseases
EGFR Tyrosine Kinase Inhibitor Resistance
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
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- Product Name
Secondary Antibody
- CAT
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Reconstitution Buffer
- CAT
- Product Name
Recommended Dilution Buffer
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- Product Name
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