Rabbit Anti-RTN4 Recombinant Antibody (clone R05-4C9) (CAT#: VS3-XY3491)

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human RTN4

• Species Reactivity
• Human

• Clone
• R05-4C9

• Applications
• WB, IHC-P, ICC, IF, IP, FC

• Related Disease
• Temporal Lobe Epilepsy; Anosognosia

• Clonality
• Monoclonal

• Aggregation
• < 5%

• Format
• Liquid

• Buffer
• PBS (pH 7.4), 150 mM NaCl and 50% glycerol

• Preservative
• 0.02% sodium azide

• Storage
• Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• WB: 1/500-1/1000
  IHC: 1/50-1/100
  IF: 1/50-1/200
  IP: 1/20
  FC: 1/50-1/100

• Alternative Names
• ASY; NSP; NOGO; RTN-X; NSP-CL; RTN4-A; RTN4-C; RTN4-B1; RTN4-B2; NI220/250; Nbla00271; Nbla10545

• Gene ID
• 57142

• UniProt ID
• Q9NQC3

• Long Name
• Reticulon 4

• Cellular Localization
• Cell membrane

• Post Translation Modifications
• Ubiquitination at Lys1090, Lys1104, and Lys1171 (NX_Q9NQC3 [NX_Q9NQC3-1])
  Modification sites at PhosphoSitePlus (Q9NQC3)
  Glycosylation from GlyGen (Q9NQC3) 5 sites, 1 O-linked glycan (5 sites)

• Protein Refseq
• NP_001308789.1

• Function
• Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:27619977, 25612671, 24262037).
  They regulate membrane morphogenesis in the ER by promoting tubular ER production (PubMed:27619977, 25612671, 24262037, 27786289).
  They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412).
  However each isoform have specific functions mainly depending on their tissue expression specificities (Probable).

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Recommended Dilution Buffer

• MRO-0253YJ
• Reconstitution Buffer PBS

Secondary Antibody

• 2RD-A1473-YJ
• Goat Anti-Rabbit IgG-F(ab')2 Secondary antibody

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