What is the main application for this SIRPA antibody?

This recombinant Human antibody Fab fragment is used for Inhibition (Inhib) studies. It recognizes SIRPA (Signal regulatory protein alpha) and can be used to block its interaction or signaling pathways.

Is this a full-length antibody or a fragment?

This product is an antibody Fab Fragment (HPAB-2559LY-F(E)). It is purified by affinity chromatography and supplied in PBS. The purity is greater than 95% as determined by SDS-PAGE.

Human Anti-SIRPA Recombinant Antibody; Fab Fragment (HPAB-2559LY-F(E))

CAT#: HPAB-2559LY-F(E)

This product is a recombinant Human antibody Fab fragment that recognizes SIRPA. The antibody was purified by affinity chromatography.

Gene Expression

Normal Tissue Figure 1 Cerebral cortex

Neuropil
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2776/6761_B_8_5.jpg

Normal Tissue Figure 2 Colon

Endocrine cells
Staining:Medium
Intensity: Moderate
Enterocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2776/6761_A_7_3.jpg

Normal Tissue Figure 3 Lymph node

Non-germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2776/6761_A_8_8.jpg

RNA Expression Figure 4 RNA cell line category: Cell line enhanced (fHDF/TERT166, RPTEC TERT1, SK-MEL-30)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000198053-SIRPA

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Specifications

Host Species
Human

Type
Human Fab

Specificity
Human SIRPA

Species Reactivity
Human

Applications
Inhib

Product Property

Purity
>95% as determined by SDS-PAGE

Concentration
Please refer to the vial label for the specific concentration.

Buffer
PBS

Preservative
No preservatives

Storage
Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Alternative Names
Signal regulatory protein α

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Breast cancer biomarkers at key points during disease progression

Effective Inhibition Studies

We utilized this Fab fragment to study the signaling pathways involving SIRPA. The inhibition assays were successful, demonstrating the antibody's ability to block the receptor's interaction. The purity of the recombinant protein was excellent for these sensitive biological assays.

High Quality Fab Fragment

The affinity-purified Fab fragment was stable and easy to use. We confirmed its purity via SDS-PAGE before use. It is a valuable tool for our research into signal regulatory proteins, providing specific binding without the Fc-mediated effects of full antibodies.

Q&As

What is the main application for this SIRPA antibody?

A: This recombinant Human antibody Fab fragment is used for Inhibition (Inhib) studies. It recognizes SIRPA (Signal regulatory protein alpha) and can be used to block its interaction or signaling pathways.
Is this a full-length antibody or a fragment?

A: This product is an antibody Fab Fragment (HPAB-2559LY-F(E)). It is purified by affinity chromatography and supplied in PBS. The purity is greater than 95% as determined by SDS-PAGE.

View the frequently asked questions answered by Creative Biolabs Support.

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Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - HPAB-2559LY-F(E).pdf

MSDS

MSDS - HPAB-2559LY-F(E).pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

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