Human Anti-SIRPA Recombinant Antibody scFv Fragment (PABJ-0084-S(P))
CAT#: PABJ-0084-S(P)
This product is a Human antibody scFv fragment that recognizes Human SIRPA. This antibody is specific for human and cynomolgus monkey SIRPα. PABJ-0084-S(P) potently antagonizes the SIRPα/CD47 interaction.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Neuropil
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2776/6761_B_8_5.jpg
Normal Tissue
Figure 2 Colon
Endocrine cells
Staining:Medium
Intensity: Moderate
Enterocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2776/6761_A_7_3.jpg
Normal Tissue
Figure 3 Lymph node
Non-germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2776/6761_A_8_8.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (fHDF/TERT166, RPTEC TERT1, SK-MEL-30)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000198053-SIRPA
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Specifications
- Host Species
- Human
- Type
- Human scFv
- Specificity
- Human SIRPA
- Species Reactivity
- Human, Monkey
- Applications
- ELISA, Block
Product Property
- Purification
- Purified
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Buffer
- PBS
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Enzyme-linked Immunosorbent Assay, Blocking.
Target
- Alternative Names
- BIT; MFR; P84; SIRP; MYD-1; SHPS1; CD172A; PTPNS1; tyrosine-protein phosphatase non-receptor type substrate 1; CD172 antigen-like family member A; brain-immunoglobulin-like molecule with tyrosine-based activation motifs; inhibitory receptor SHPS-1; macrophage fusion receptor; myd-1 antigen; tyrosine phosphatase SHP substrate 1
- Gene ID
- 140885
- UniProt ID
- P78324
REVIEWS AND Q&AS
CITATIONS
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Ideal for Blocking Assays
We've successfully employed this scFv fragment in blocking assays, where it consistently disrupts the SIRPA/CD47 interaction. This property is pivotal in unveiling immune escape mechanisms, making it invaluable for our study of cancer immunotherapies.
Reliable and Specific
The high specificity of this antibody fragment has streamlined our ELISA protocols, providing reliable results with minimal interference. It has become a cornerstone in our assays, allowing for precise protein quantification.
Exceptional Versatility
Its versatility in applications ranging from ELISA to blocking experiments has greatly benefited our lab. This flexibility supports a wide array of research focuses, from oncology to autoimmune disease studies.
Q&As
-
What is the primary application of the Human Anti-SIRPA scFv Fragment?
A: The Human Anti-SIRPA scFv Fragment is prominently used in enzyme-linked immunosorbent assays (ELISA) and blocking applications. This makes it an essential tool for researching the SIRPA/CD47 interaction, especially in immune response studies and cancer.
-
What specific targets does this antibody fragment bind to?
A: The antibody fragment binds specifically to the SIRPα protein on myeloid cells and recognizes both human and cynomolgus monkey proteins. This specificity is vital for research involving these species, facilitating preclinical model studies.
-
How does the scFv format enhance its research utility?
A: The small size of the scFv format allows for better tissue penetration and accessibility to hidden epitopes, making it highly effective for both in vitro and in vivo applications.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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| CAT | Product Name | Application | Type |
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| TAB-453CT | Human Anti-SIRPA Recombinant Antibody (TAB-453CT) | Cyt, IF, FC | Chimeric (mouse/human) IgG4 |
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| CAT | Product Name | Application | Type |
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| TAB-454CT | Anti-Human SIRPA Recombinant Antibody (AM4-1) | ELISA | Human antibody |
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| CAT | Product Name | Application | Type |
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| BRD-0465MZ | Chicken Anti-PTPNS1 Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
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| NEUT-1970CQ | Recombinant Rat Anti-Sirpa Antibody (P84) | FC, BL, IF, IHC, IP | IgG1, κ |
| CAT | Product Name | Application | Type |
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| NEUT-1971CQ | Recombinant Mouse Anti-Sirpa Antibody (CBL650) | WB, FC, CyTOF, Neut | IgG2b |
| CAT | Product Name | Application | Type |
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| MOR-4429 | Hi-Affi™ Recombinant Rabbit Anti-SIRPA Monoclonal Antibody (SI522DS) | ELISA | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0023-LSX-S(P) | Human Anti-SIRPA Recombinant Antibody (clone 29-AM4-1); scFv Fragment | ELISA | Humanized scFv |
| HPAB-0024-LSX-S(P) | Human Anti-SIRPA Recombinant Antibody (clone 29-AM3-4); scFv Fragment | ELISA | Humanized scFv |
| HPAB-2559LY-S(P) | Human Anti-SIRPA Recombinant Antibody; scFv Fragment (HPAB-2559LY-S(P)) | Inhib | Human scFv |
| PABJ-0078-S(P) | Human Anti-SIRPA Recombinant Antibody scFv Fragment (PABJ-0078-S(P)) | ELISA | Human scFv |
| PABJ-0085-S(P) | Human Anti-SIRPA Recombinant Antibody scFv Fragment (PABJ-0085-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0023-LSX-F(E) | Human Anti-SIRPA Recombinant Antibody (clone 29-AM4-1); Fab Fragment | ELISA | Humanized Fab |
| HPAB-0024-LSX-F(E) | Human Anti-SIRPA Recombinant Antibody (clone 29-AM3-4); Fab Fragment | ELISA | Humanized Fab |
| HPAB-0025-LSX-F(E) | Human Anti-SIRPA Recombinant Antibody (clone 29-AM4-5); Fab Fragment | ELISA | Humanized Fab |
| HPAB-2559LY-F(E) | Human Anti-SIRPA Recombinant Antibody; Fab Fragment (HPAB-2559LY-F(E)) | Inhib | Human Fab |
| PABJ-0078-F(E) | Human Anti-SIRPA Recombinant Antibody Fab Fragment (PABJ-0078-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-080CN | Human Anti-SIRPA Recombinant Antibody (clone 29-AM3-35) | ELISA, Inhib, FuncS | Human IgG |
| NS-080CN-F(E) | Human Anti-SIRPA Recombinant Antibody (clone 29-AM3-35); Fab Fragment | ELISA | Human Fab |
| NS-080CN-S(P) | Human Anti-SIRPA Recombinant Antibody (clone 29-AM3-35); scFv Fragment | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY86 | Human Anti-SIRPA (clone 29-AM3-35) scFv-Fc Chimera | ELISA, Inhib | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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