Rabbit Anti-TCF3 Recombinant Antibody (VS3-CJ679)
CAT#: VS3-CJ679
This product is a rabbit antibody that recognizes human TCF3.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line MCF7
Immunofluorescent staining of human cell line MCF7 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/62476/1148_B11_1_selected.jpg
Normal Tissue
Figure 2 Bone marrow
Hematopoietic cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18351/40328_B_6_4.jpg
Normal Tissue
Figure 3 Lymph node
Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: nuclear Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18351/40328_A_7_8.jpg
Normal Tissue
Figure 4 Colon
Glandular cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18351/40328_A_9_3.jpg
Normal Tissue
Figure 5 Testis
Spermatogonia cells Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18351/40328_A_6_6.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (REH, U-698)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000071564-TCF3
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Specifications
- Immunogen
- Recombinant protein
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human TCF3
- Species Reactivity
- Human
- Applications
- WB, FC
- Conjugate
- Unconjugated
Product Property
- Purification
- Protein A affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- 40% Glycerol, 1% BSA, TBS, pH7.4.
- Preservative
- 0.05% Sodium Azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Western Blot, Flow Cytometry.
Target
- Alternative Names
- E2A; E47; p75; AGM8; ITF1; VDIR; AGM8A; AGM8B; TCF-3; bHLHb21
- Gene ID
- 6929
- UniProt ID
- P15923
- Cellular Localization
- Nucleus
- Post Translation Modifications
- Phosphorylated following NGF stimulation.
Undergoes Notch-induced ubiquitination and subsequent proteasomal degradation which is mediated by ASB1 or ASB2, the substrate-recognition components of probable ECS E3 ubiquitin-protein ligase complexes.
- Protein Refseq
- NP_001129611.1; NP_003191.1
- Function
- Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition (By similarity).
Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation (By similarity).
Together with TCF15, required for the mesenchymal to epithelial transition (By similarity).
Dimers bind DNA on E-box motifs: 5'-CANNTG-3' (By similarity).
Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer (PubMed:2493990).
Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region (By similarity).
Isoform E47:
Facilitates ATOH7 binding to DNA at the consensus sequence 5'-CAGGTG-3', and positively regulates transcriptional activity.
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Related Diseases
Breast Cancer
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Gastric Cancer
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Prostate Cancer
Throid Cancer
Related Signaling Pathways
Canonical Wnt Signaling Pathway
Non-Canonical Wnt Signaling Pathway
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "TCF3"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3565z | Mouse Anti-TCF3 Recombinant Antibody (clone 32G10) | WB, ELISA, FC | Mouse IgG1 |
| MOB-0826CT | Recombinant Mouse anti-Human TCF3 Monoclonal antibody (EML2314) | WB | |
| MRO-1475-CN | Rabbit Anti-TCF3 Recombinant Antibody (clone CBACN-548) | WB, FC | Rabbit IgG |
| VS3-XY1490 | Mouse Anti-TCF3 Recombinant Antibody (clone 6B8) | ELISA, WB, FC | Mouse IgG1 |
| VS13-YC1146 | Rabbit Anti-TCF3 Recombinant Antibody (VS13-YC1146) | IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| EPAF-1710LC | Mouse Anti-TCF3 Recombinant Antibody (clone Yae) | WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7136 | Anti-Mouse TCF3 Immunohistochemistry Kit | IHC |
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