Human Anti-TFPI Recombinant Antibody (clone ch2F22); scFv Fragment (CAT#: PSBC-539)
This product is a recombinant Mouse antibody scFv Fragment that can recognize TFPI. mAb2F22, was raised against the N-terminal fragment of TFPI (1-79). mAb2F22 bound exclusively to the K1 domain of TFPI (KD ∼1 nm) and not to the K2 domain. mAb2F22 interfered with inhibition of both FVIIa and FXa activities and restored clot formation. mAb2F22 blocked TFPI inhibition of both FVIIa and FXa activities and mapped a FXa exosite for binding to K1.
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Normal Tissue
RNA Expression
Figure 1 IHC staining of human smooth muscle
(Immunohistochemical staining of human smooth muscle shows distinct positivity in endothelial.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5575/ihc_selected.jpg
(Immunohistochemical staining of human smooth muscle shows distinct positivity in endothelial.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5575/ihc_selected.jpg
Figure 2 IHC staining of human colon
(Immunohistochemical staining of human colon shows distinct cytoplasmic positivity in endothelium.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20842/ihc_selected.jpg
(Immunohistochemical staining of human colon shows distinct cytoplasmic positivity in endothelium.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20842/ihc_selected.jpg
Figure 3 Cerebral cortex
(Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20842/46624_B_9_5.jpg
(Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20842/46624_B_9_5.jpg
Figure 4 Colon
(Endocrine cells Staining: High Intensity: Strong Endothelial cells Staining: High Intensity: Strong Quantity:>75% Enterocytes Staining: High Intensity: Strong Quantity:>75% Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity: 75%-25% Peripheral nerve/ganglion Staining: Low Intensity: Weak)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20842/46624_A_7_3.jpg
(Endocrine cells Staining: High Intensity: Strong Endothelial cells Staining: High Intensity: Strong Quantity:>75% Enterocytes Staining: High Intensity: Strong Quantity:>75% Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity: 75%-25% Peripheral nerve/ganglion Staining: Low Intensity: Weak)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20842/46624_A_7_3.jpg
Figure 5 Testis
(Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20842/46624_A_4_6.jpg
(Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20842/46624_A_4_6.jpg
Figure 6 Placenta
(Decidual cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Trophoblastic cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20842/46624_A_2_7.jpg
(Decidual cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Trophoblastic cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20842/46624_A_2_7.jpg
Figure 7 RNA cell line category: Cell line enhanced (HHSteC, HUVEC TERT2, LHCN-M2, TIME)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000003436-TFPI
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000003436-TFPI
Specifications
- Host Species
- Human
- Type
- Mouse scFv
- Specificity
- Human TFPI
- Species Reactivity
- Human
- Clone
- ch2F22
- Applications
- ELISA, FC, Neut
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- TFPI; tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor); EPI; TFI; LACI; TFPI1; tissue factor pathway inhibitor; anti-convertin; extrinsic pathway inhibitor; anti-TFPI
- Gene ID
- 7035
- UniProt ID
- P10646
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-734 | Anti-TFPI Recombinant Antibody (Concizumab) | ELISA, IP, FC, FuncS, Neut, IF, WB | IgG4 - kappa |
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