AbPlus™ Anti-TGFB1 Magnetic Beads (VS-0424-XY252)

CAT#: VS-0424-XY252

The AbPlus Anti-TGFB1 Magnetic Beads (VS-0424-XY252) is an innovative affinity resin which is bound with anti-TGFB1 specific antibody. The beads were designed for small-scale affinity purification and immunoprecipitation (IP) of TGFB1 protein under native and denaturing conditions.

Gene Expression
Figure 1 IF staining of human cell line U-2 OS Figure 2 IHC staining of human bone marrow Figure 3 IF staining of human cell line HEL Figure 4 Bone marrow Figure 5 RNA cell line category: Low cell line specificity

Specifications

  • Applications
  • Immunoprecipitation, Protein Purification
  • Matrix
  • Magrose bead (> 50 μmol/mL gel)
  • Bead Ligand
  • Anti-TGFB1 specific antibody
  • Target
  • TGFB1
  • Target Species
  • Human
  • Bead Capacity
  • 20-30 mg/mL binding antibody
  • Bead size
  • 10-37 μm
  • Stability
  • pH 2-14
  • Format
  • 20% Suspension
  • Buffer
  • PBS, pH 7.4, with 1% BSA
  • Preservative
  • 0.03% Proclin 300
  • Storage
  • Stored at 4°C, and is stable for up to 2 years. Do not centrifuge, dry or freeze the magnetic beads.

Applications

  • Application Notes
  • The beads are in suspension and will settle upon storage. Prior to use, mix the vial gently (do not vortex) to ensure delivery of proper bead volume.

Target

  • Introduction
  • This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.
  • Alternative Names
  • TGFB1; transforming growth factor; beta 1; CED; LAP; DPD1; TGFB; TGFbeta; transforming growth factor beta-1; TGF-beta-1; latency-associated peptide; prepro-transforming growth factor beta-1
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