Human Anti-TGFB1 (clone 31G9) scFv-Fc Chimera (CAT#: VS-0125-FY14)
scFv-Fc dimers have shown great promise in effectively blocking the activity of TGF-β, a cytokine often linked to various pathological conditions. By inhibiting TGF-β function, these dimers may offer new therapeutic avenues for addressing diseases such as autoimmune disorders and certain types of tumors, where TGF-β plays a critical role in disease progression. This innovative approach could pave the way for more targeted and effective treatments, ultimately improving patient outcomes in conditions characterized by dysregulated TGF-β signaling.
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Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol & the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73356/1901_C17_1_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol & the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73356/1901_C17_1_selected.jpg
Figure 2 IHC staining of human bone marrow
(Immunohistochemical staining of human bone marrow shows strong cytoplasmic positivity in bone marrow poietic cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/361/ihc_selected.jpg
(Immunohistochemical staining of human bone marrow shows strong cytoplasmic positivity in bone marrow poietic cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/361/ihc_selected.jpg
Figure 3 IF staining of human cell line HEL
(Immunofluorescent staining of human cell line HEL shows localization to Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73356/1812_G3_5_cr5a09c41109818_blue_red_green.jpg
(Immunofluorescent staining of human cell line HEL shows localization to Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73356/1812_G3_5_cr5a09c41109818_blue_red_green.jpg
Figure 4 Bone marrow
(Hematopoietic cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/361/2675_B_6_4.jpg
(Hematopoietic cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/361/2675_B_6_4.jpg
Figure 5 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000105329-TGFB1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000105329-TGFB1
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Species Reactivity
- Human
- Clone
- 31G9
- Applications
- ELISA, Blocking
- Related Disease
- The scFv-Fc dimers can effectively hinder the function of TGF-β, which may hold significant therapeutic potential for diseases associated with TGF-β, such as autoimmune diseases and tumors.
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Block
Target
- Alternative Names
- Transforming Growth Factor Beta 1; Prepro-Transforming Growth Factor Beta-1; TGF-Beta-1; TGFB; Transforming Growth Factor, Beta 1; Transforming Growth Factor Beta-1; Camurati-Engelmann Disease
- Gene ID
- 7040
- UniProt ID
- P01137
- Sequence Similarities
- Belongs to the TGF-beta family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- Transforming growth factor beta-1 proprotein: The precursor proprotein is cleaved in the Golgi apparatus by FURIN to form Transforming growth factor beta-1 (TGF-beta-1) and Latency-associated peptide (LAP) chains, which remain non-covalently linked, rendering TGF-beta-1 inactive.
- Protein Refseq
- XP_011525544.1; XP_054177872.1; NP_000651.3
- Function
- Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.
Recommended Products
Secondary Antibody
Isotype Control
Related Resources
Inflammatory Bowel Diseases
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-605CL | Human Anti-TGFB1 Recombinant Antibody (TAB-605CL) | ELISA | Human IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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