Human Anti-TGFB1 (clone 31G9) scFv-Fc Chimera
CAT#: VS-0125-FY14
scFv-Fc dimers have shown great promise in effectively blocking the activity of TGF-β, a cytokine often linked to various pathological conditions. By inhibiting TGF-β function, these dimers may offer new therapeutic avenues for addressing diseases such as autoimmune disorders and certain types of tumors, where TGF-β plays a critical role in disease progression. This innovative approach could pave the way for more targeted and effective treatments, ultimately improving patient outcomes in conditions characterized by dysregulated TGF-β signaling.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73356/1901_C17_1_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human bone marrow
Immunohistochemical staining of human bone marrow shows strong cytoplasmic positivity in bone marrow poietic cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/361/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IF staining of human cell line HEL
Immunofluorescent staining of human cell line HEL shows localization to Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73356/1812_G3_5_cr5a09c41109818_blue_red_green.jpg
Normal Tissue
Figure 4 Bone marrow
Hematopoietic cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/361/2675_B_6_4.jpg
RNA Expression
Figure 5 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000105329-TGFB1
❮
❯
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Species Reactivity
- Human
- Clone
- 31G9
- Applications
- ELISA, Blocking
- Related Disease
- The scFv-Fc dimers can effectively hinder the function of TGF-β, which may hold significant therapeutic potential for diseases associated with TGF-β, such as autoimmune diseases and tumors.
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Block
Target
- Alternative Names
- Transforming Growth Factor Beta 1; Prepro-Transforming Growth Factor Beta-1; TGF-Beta-1; TGFB; Transforming Growth Factor, Beta 1; Transforming Growth Factor Beta-1; Camurati-Engelmann Disease
- Gene ID
- 7040
- UniProt ID
- P01137
- Sequence Similarities
- Belongs to the TGF-beta family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- Transforming growth factor beta-1 proprotein: The precursor proprotein is cleaved in the Golgi apparatus by FURIN to form Transforming growth factor beta-1 (TGF-beta-1) and Latency-associated peptide (LAP) chains, which remain non-covalently linked, rendering TGF-beta-1 inactive.
- Protein Refseq
- XP_011525544.1; XP_054177872.1; NP_000651.3
- Function
- Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS-0125-FY14. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Related Diseases
Inflammatory Bowel Diseases
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "Clone 31G9"
- CAT
- Product Name
See other products for "Tgfb1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-98 | Mouse Anti-Tgfb1 Recombinant Antibody (clone CB57B9) | Neut, FC | Mouse IgG1, κ |
| HPAB-0492-CN | Human Anti-TGFB1 Recombinant Antibody (HPAB-0492-CN) | ELISA, FC, IF, Neut | Human IgG2 |
| HPAB-0493-CN | Human Anti-TGFB1 Recombinant Antibody (HPAB-0493-CN) | ELISA, FC, IF, Neut | Human IgG2 |
| HPAB-0494-CN | Human Anti-TGFB1 Recombinant Antibody (HPAB-0494-CN) | ELISA, Neut | Human IgG4 |
| HPAB-0495-CN | Human Anti-TGFB1 Recombinant Antibody (HPAB-0495-CN) | ELISA, Neut | Human IgG4 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-605CL | Human Anti-TGFB1 Recombinant Antibody (TAB-605CL) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-632CT | Mouse Anti-TGFB1 Recombinant Antibody (TAB-632CT) | ELISA, WB, FC, IP | Mouse IgG |
| TAB-633CT | Mouse Anti-TGFB1 Recombinant Antibody (TAB-633CT) | ELISA, WB, FC, IP | Mouse IgG |
| TAB-634CT | Mouse Anti-TGFB1 Recombinant Antibody (TAB-634CT) | ELISA, WB, FC, IP | Mouse IgG |
| TAB-632CT-F(E) | Mouse Anti-TGFB1 Recombinant Antibody; Fab Fragment (TAB-632CT-F(E)) | ELISA, WB, FC, IP | Mouse Fab |
| TAB-633CT-F(E) | Mouse Anti-TGFB1 Recombinant Antibody; Fab Fragment (TAB-633CT-F(E)) | ELISA, WB, FC, IP | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-635CT-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (TAB-635CT-S(P)) | ELISA, WB, FC, IP | Human scFv |
| TAB-636CT-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (TAB-636CT-S(P)) | ELISA, WB, FC, IP | Human scFv |
| TAB-637CT-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (TAB-637CT-S(P)) | ELISA, WB, FC, IP | Human scFv |
| TAB-638CT-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (TAB-638CT-S(P)) | ELISA, WB, FC, IP | Human scFv |
| TAB-639CT-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (TAB-639CT-S(P)) | ELISA, WB, FC, IP | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0853MZ | Chicken Anti-TGF beta-1 Polyclonal IgY | ELISA, IHC, WB | Chicken antibody |
| BRD-1110MZ | Chicken Anti-Human TGF (beta) Polyclonal IgY Conjugated to PE-Cy5.5 | ELISA, WB, IHC, ICC, IF, IP, FC | Chicken antibody |
| BRD-1111MZ | Chicken Anti-Human TGF (beta) Polyclonal IgY Conjugated to PE-Cy7 | ELISA, WB, IHC, ICC, IF, IP, FC | Chicken antibody |
| BRD-1112MZ | Chicken Anti-Human TGF (beta) Polyclonal IgY Conjugated to PerCP | ELISA, WB, IHC, ICC, IF, IP, FC | Chicken antibody |
| BRD-1113MZ | Chicken Anti-Human TGF (beta) Polyclonal IgY Conjugated to PerCP-Cy5.5 | ELISA, WB, IHC, ICC, IF, IP, FC | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2003CQ | Mouse Anti-TGFB1 Recombinant Antibody (clone CBL443) | Neut | Mouse IgG1 |
| NEUT-2004CQ | Mouse Anti-Tgfb1 Recombinant Antibody (NEUT-2004CQ) | FC, WB, IP, Neut | Mouse IgG2b, κ |
| NEUT-2005CQ | Mouse Anti-Tgfb1 Recombinant Antibody (NEUT-2005CQ) | FC, IP, Neut, WB | Mouse IgG1, κ |
| NEUT-2006CQ | Mouse Anti-TGFB1 Recombinant Antibody (clone 1D11.16.8) | Neut | Mouse IgG1 |
| NEUT-2007CQ | Mouse Anti-TGFB1 Recombinant Antibody (NEUT-2007CQ) | IHC-Fr, WB, ELISA, IHC-Fr, Neut, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2009CQ | Mouse Anti-TGFB1 Recombinant Antibody (clone 9016.2) | ELISA, Inhib, WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3550 | Rabbit Anti-TGFB1 Recombinant Antibody (clone DS3550AB) | WB | Rabbit IgG |
| MOR-4451 | Rabbit Anti-TGFB1 Recombinant Antibody (clone SI544DS) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0492-CN-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (HPAB-0492-CN-S(P)) | ELISA, FC, IF, Neut | Human scFv |
| HPAB-0493-CN-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (HPAB-0493-CN-S(P)) | ELISA, FC, IF, Neut | Human scFv |
| HPAB-0494-CN-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (HPAB-0494-CN-S(P)) | ELISA, Neut | Human scFv |
| HPAB-0495-CN-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (HPAB-0495-CN-S(P)) | ELISA, Neut | Human scFv |
| HPAB-0496-CN-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (HPAB-0496-CN-S(P)) | ELISA, Neut | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0492-CN-F(E) | Human Anti-TGFB1 Recombinant Antibody; Fab Fragment (HPAB-0492-CN-F(E)) | ELISA, FC, IF, Neut | Human Fab |
| HPAB-0493-CN-F(E) | Human Anti-TGFB1 Recombinant Antibody; Fab Fragment (HPAB-0493-CN-F(E)) | ELISA, FC, IF, Neut | Human Fab |
| HPAB-0494-CN-F(E) | Human Anti-TGFB1 Recombinant Antibody; Fab Fragment (HPAB-0494-CN-F(E)) | ELISA, Neut | Human Fab |
| HPAB-1188LY-F(E) | Human Anti-TGFB1 Recombinant Antibody; Fab Fragment (HPAB-1188LY-F(E)) | ELISA, WB, ICC, IP | Human Fab |
| HPAB-2101-FY-F(E) | Human Anti-TGFB1 Recombinant Antibody (clone SL15A); Fab Fragment | Inhib, ELISA | Human Fab, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-140 | Afuco™ Anti-TGFB1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-140) | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
| AFC-TAB-762 | Afuco™ Anti-TGFB1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-762) | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN1265 | PE-A*02:01/Human TGFB1 (RLSSCVPVA) MHC Tetramer | FCM, IHC | |
| MHC-CN1266 | APC-A*02:01/Human TGFB1 (RLSSCVPVA) MHC Tetramer | FCM, IHC | |
| MHC-CN1267 | FITC-A*02:01/Human TGFB1 (RLSSCVPVA) MHC Tetramer | FCM, IHC | |
| MHC-CN1268 | A*02:01/Human TGFB1 (RLSSCVPVA) MHC Tetramer | FCM, IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY252 | AbPlus™ Anti-TGFB1 Magnetic Beads (VS-0424-XY252) | IP, Protein Purification | |
| VS-0724-YC1506 | AbPlus™ Anti-TGFB1 Magnetic Beads (VS-0724-YC1506) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY503 | Mouse Anti-NHP TGFB1 Recombinant Antibody (clone 1D11.16.8) | WB, IF, ELISA | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7208 | Anti-TGFB1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7209 | Anti-Mouse TGFB1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7210 | Anti-Rat TGFB1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC230 | Recombinant Anti-TGFB1 Biparatopic Antibody, Tandem scFv | ELISA, FC, ICC, IF, IP, Neut | Tandem scFv |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: IP, IF, FuncS, FC, Neut, ELISA, IHC
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: WB, IHC, ELISA, FC
Application: ELISA, FuncS
-2.png)
Application: ELISA
Application: Inhib, FC, WB
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
