Anti-Human TGF-β Recombinant Antibody (TAB-140)
CAT#: TAB-140
Recombinant monoclonal antibody to TGF-beta. It is a human monoclonal antibody and an immunomodulator. It is intended for the treatment of idiopathic pulmonary fibrosis (IPF), focal segmental glomerulosclerosis, and cancer (kidney cancer and melanoma).
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73356/1901_C17_1_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human bone marrow
Immunohistochemical staining of human bone marrow shows strong cytoplasmic positivity in bone marrow poietic cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/361/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IF staining of human cell line HEL
Immunofluorescent staining of human cell line HEL shows localization to Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73356/1812_G3_5_cr5a09c41109818_blue_red_green.jpg
Normal Tissue
Figure 4 Bone marrow
Hematopoietic cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/361/2675_B_6_4.jpg
RNA Expression
Figure 5 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000105329-TGFB1
❮
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Specifications
- Immunogen
- A synthetic peptide (17 aa) derived from C terminal human TGF beta 3 protein.
- Host Species
- Human
- Derivation
- Human
- Type
- IgG4 - kappa
- Specificity
- Tested positive against native human antigen.
- Species Reactivity
- Human
- Applications
- Neut, ELISA, IF, IP, FuncS, FC, ICC, PK, PET
- MW
- 144.4 kDa
- Related Disease
- Idiopathic pulmonary fibrosis
Product Property
- Purity
- >95.0% as determined by analysis by SDS-PAGE.
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- The TGFB1 antibody has been reported in applications of Neut, ELISA, IF, IP, FuncS, FC, ICC, PK, PET.
Target
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Impressive Versatility
I used Fresolimumab in synthetic biology experiments to target TGF-β pathways. It enabled precise control over cellular behaviors, aiding my research tremendously. The versatility of this antibody is quite impressive.
Superb Integration
Fresolimumab's compatibility with fluorescent labeling for live imaging studies has been a game-changer. It enabled us to visualize TGF-β interactions in real-time, enhancing our research data significantly.
Useful for biomechanical studies
Applying Fresolimumab in biomechanical studies of tissue stiffness helped us understand pathological stiffness and remodeling better. Its effects on TGF-β gave us highly valuable biomechanical insights.
Q&As
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Is it possible to employ fresolimumab in research on how the environment affects animal biology?
A: Yes, Fresolimumab can be employed to explore how environmental stressors affect TGF-β signaling pathways in wildlife, thus providing insights into ecological adaptations and impacts.
-
What uses is fresolimumab useful for in tissue engineering research?
A: In tissue engineering, Fresolimumab could be used to modulate fibrotic responses and enhance the regenerative capacity of engineered tissues by targeting TGF-β pathways that control scar tissue formation.
-
What is the potential contribution of Fresolimumab to biomechanical tissue stiffness studies?
A: By inhibiting TGF-β, Fresolimumab can be used to study changes in tissue stiffness in various biomechanical research applications, providing insights into pathological stiffness and remodeling.
View the frequently asked questions answered by Creative Biolabs Support.
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Related Diseases
Inflammatory Bowel Diseases
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-605CL | Human Anti-TGFB1 Recombinant Antibody (TAB-605CL) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-632CT-S(P) | Mouse Anti-TGFB1 Recombinant Antibody; scFv Fragment (TAB-632CT-S(P)) | ELISA, WB, FC, IP | Mouse scFv |
| TAB-633CT-S(P) | Mouse Anti-TGFB1 Recombinant Antibody; scFv Fragment (TAB-633CT-S(P)) | ELISA, WB, FC, IP | Mouse scFv |
| TAB-634CT-S(P) | Mouse Anti-TGFB1 Recombinant Antibody; scFv Fragment (TAB-634CT-S(P)) | ELISA, WB, FC, IP | Mouse scFv |
| TAB-632CT-F(E) | Mouse Anti-TGFB1 Recombinant Antibody; Fab Fragment (TAB-632CT-F(E)) | ELISA, WB, FC, IP | Mouse Fab |
| TAB-633CT-F(E) | Mouse Anti-TGFB1 Recombinant Antibody; Fab Fragment (TAB-633CT-F(E)) | ELISA, WB, FC, IP | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-635CT-F(E) | Human Anti-TGFB1 Recombinant Antibody; Fab Fragment (TAB-635CT-F(E)) | ELISA, WB, FC, IP | Human Fab |
| TAB-636CT-F(E) | Human Anti-TGFB1 Recombinant Antibody; Fab Fragment (TAB-636CT-F(E)) | ELISA, WB, FC, IP | Human Fab |
| TAB-637CT-F(E) | Human Anti-TGFB1 Recombinant Antibody; Fab Fragment (TAB-637CT-F(E)) | ELISA, WB, FC, IP | Human Fab |
| TAB-638CT-F(E) | Human Anti-TGFB1 Recombinant Antibody; Fab Fragment (TAB-638CT-F(E)) | ELISA, WB, FC, IP | Human Fab |
| TAB-639CT-F(E) | Human Anti-TGFB1 Recombinant Antibody; Fab Fragment (TAB-639CT-F(E)) | ELISA, WB, FC, IP | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0853MZ | Chicken Anti-TGF beta-1 Polyclonal IgY | ELISA, IHC, WB | Chicken antibody |
| BRD-1110MZ | Chicken Anti-Human TGF (beta) Polyclonal IgY Conjugated to PE-Cy5.5 | ELISA, WB, IHC, ICC, IF, IP, FC | Chicken antibody |
| BRD-1111MZ | Chicken Anti-Human TGF (beta) Polyclonal IgY Conjugated to PE-Cy7 | ELISA, WB, IHC, ICC, IF, IP, FC | Chicken antibody |
| BRD-1112MZ | Chicken Anti-Human TGF (beta) Polyclonal IgY Conjugated to PerCP | ELISA, WB, IHC, ICC, IF, IP, FC | Chicken antibody |
| BRD-1113MZ | Chicken Anti-Human TGF (beta) Polyclonal IgY Conjugated to PerCP-Cy5.5 | ELISA, WB, IHC, ICC, IF, IP, FC | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2003CQ | Mouse Anti-TGFB1 Recombinant Antibody (clone CBL443) | Neut | Mouse IgG1 |
| NEUT-2004CQ | Mouse Anti-Tgfb1 Recombinant Antibody (NEUT-2004CQ) | FC, WB, IP, Neut | Mouse IgG2b, κ |
| NEUT-2005CQ | Mouse Anti-Tgfb1 Recombinant Antibody (NEUT-2005CQ) | FC, IP, Neut, WB | Mouse IgG1, κ |
| NEUT-2006CQ | Mouse Anti-TGFB1 Recombinant Antibody (clone 1D11.16.8) | Neut | Mouse IgG1 |
| NEUT-2007CQ | Mouse Anti-TGFB1 Recombinant Antibody (NEUT-2007CQ) | IHC-Fr, WB, ELISA, IHC-Fr, Neut, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2009CQ | Mouse Anti-TGFB1 Recombinant Antibody (clone 9016.2) | ELISA, Inhib, WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3550 | Rabbit Anti-TGFB1 Recombinant Antibody (clone DS3550AB) | WB | Rabbit IgG |
| MOR-4451 | Rabbit Anti-TGFB1 Recombinant Antibody (clone SI544DS) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0018-YC-F(E) | Human Anti-TGFB1 Recombinant Antibody; Fab Fragment (HPAB-0018-YC-F(E)) | ELISA, Neut | Humanized Fab |
| HPAB-0308CQ-F(E) | Mouse Anti-TGFB1 Recombinant Antibody (clone mAb 2471); Fab Fragment | ELISA, Neut, FC | Mouse Fab |
| HPAB-0309CQ-F(E) | Mouse Anti-TGFB1 Recombinant Antibody (clone mAb 1021); Fab Fragment | ELISA, Neut, FC | Mouse Fab |
| HPAB-0310CQ-F(E) | Mouse Anti-TGFB1 Recombinant Antibody (clone mAb 3821); Fab Fragment | ELISA, Neut, FC | Mouse Fab |
| HPAB-0311CQ-F(E) | Human Anti-TGFB1 Recombinant Antibody; Fab Fragment (HPAB-0311CQ-F(E)) | ELISA, Neut | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0392-YC-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (HPAB-N0392-YC-S(P)) | ELISA, Inhib | Human scFv |
| HPAB-N0393-YC-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (HPAB-N0393-YC-S(P)) | ELISA, Inhib | Human scFv |
| HPAB-0037-WJ-S(P) | Mouse Anti-TGFB1 Recombinant Antibody; scFv Fragment (HPAB-0037-WJ-S(P)) | ELISA, WB | Mouse scFv |
| HPAB-0737LY-S(P) | Mouse Anti-TGFB1 Recombinant Antibody; scFv Fragment (HPAB-0737LY-S(P)) | ELISA | Mouse scfv |
| HPAB-1188LY-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (HPAB-1188LY-S(P)) | ELISA, WB, ICC, IP | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-140 | Afuco™ Anti-TGFB1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-140) | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
| AFC-TAB-762 | Afuco™ Anti-TGFB1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-762) | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN1265 | PE-A*02:01/Human TGFB1 (RLSSCVPVA) MHC Tetramer | FCM, IHC | |
| MHC-CN1266 | APC-A*02:01/Human TGFB1 (RLSSCVPVA) MHC Tetramer | FCM, IHC | |
| MHC-CN1267 | FITC-A*02:01/Human TGFB1 (RLSSCVPVA) MHC Tetramer | FCM, IHC | |
| MHC-CN1268 | A*02:01/Human TGFB1 (RLSSCVPVA) MHC Tetramer | FCM, IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-QX1116 | Mouse Anti-TGFB1 Recombinant Antibody (clone 4C1-8C8-1E7) | IHC | Mouse IgG1 |
| VS3-QX1117 | Mouse Anti-TGFB1 Recombinant Antibody (clone 8F6-3G10-4G9) | WB, IHC | Mouse IgG1 |
| VS3-QX1118 | Mouse Anti-TGFB1 Recombinant Antibody (clone 7C9-8D7-5G1) | IHC | Mouse IgG1 |
| VS3-QX1119 | Mouse Anti-TGFB1 Recombinant Antibody (clone 3E7-G11-B7) | WB, IHC, ICC, FC, ELISA | Mouse IgG1 |
| VS-0724-XY94 | Human Anti-TGFB1 Recombinant Antibody (VS-0724-XY94) | ELISA, BLI, Neut | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY252 | AbPlus™ Anti-TGFB1 Magnetic Beads (VS-0424-XY252) | IP, Protein Purification | |
| VS-0724-YC1506 | AbPlus™ Anti-TGFB1 Magnetic Beads (VS-0724-YC1506) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY503 | Mouse Anti-NHP TGFB1 Recombinant Antibody (clone 1D11.16.8) | WB, IF, ELISA | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY14 | Human Anti-TGFB1 (clone 31G9) scFv-Fc Chimera | ELISA, Block | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7208 | Anti-TGFB1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7209 | Anti-Mouse TGFB1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7210 | Anti-Rat TGFB1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC230 | Recombinant Anti-TGFB1 Biparatopic Antibody, Tandem scFv | ELISA, FC, ICC, IF, IP, Neut | Tandem scFv |
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