Anti-TGFB1 Recombinant Antibody (TAB-762)
CAT#: TAB-762
Recombinant human monoclonal antibody expressed in CHO binding to human TGFB1. It is a human IgG4 monoclonal antibody that neutralizes TGF beta 1 which had been chosen for further development for the treatment of diffuse cutaneous systemic sclerosis, also known as scleroderma.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73356/1901_C17_1_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human bone marrow
Immunohistochemical staining of human bone marrow shows strong cytoplasmic positivity in bone marrow poietic cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/361/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IF staining of human cell line HEL
Immunofluorescent staining of human cell line HEL shows localization to Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73356/1812_G3_5_cr5a09c41109818_blue_red_green.jpg
Normal Tissue
Figure 4 Bone marrow
Hematopoietic cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/361/2675_B_6_4.jpg
RNA Expression
Figure 5 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000105329-TGFB1
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Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Human
- Type
- IgG4 - kappa
- Species Reactivity
- Human
- Applications
- Suitable for use in IF, IP, Neut, FuncS, ELISA, FC, ICC and most other immunological methods.
- Related Disease
- Scarring
Product Property
- Purity
- >95.0% as determined by analysis by SDS-PAGE.
- Storage
- Store it under sterile conditions at -20°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.
Target
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To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TAB-762, RRID: AB_3112006)
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Biosimilar Overview
Please refer to Metelimumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Metelimumab.
Related Diseases
Inflammatory Bowel Diseases
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "Tgfb1"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-605CL | Human Anti-TGFB1 Recombinant Antibody (TAB-605CL) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-632CT-S(P) | Mouse Anti-TGFB1 Recombinant Antibody; scFv Fragment (TAB-632CT-S(P)) | ELISA, WB, FC, IP | Mouse scFv |
| TAB-633CT-S(P) | Mouse Anti-TGFB1 Recombinant Antibody; scFv Fragment (TAB-633CT-S(P)) | ELISA, WB, FC, IP | Mouse scFv |
| TAB-634CT-S(P) | Mouse Anti-TGFB1 Recombinant Antibody; scFv Fragment (TAB-634CT-S(P)) | ELISA, WB, FC, IP | Mouse scFv |
| TAB-632CT-F(E) | Mouse Anti-TGFB1 Recombinant Antibody; Fab Fragment (TAB-632CT-F(E)) | ELISA, WB, FC, IP | Mouse Fab |
| TAB-633CT-F(E) | Mouse Anti-TGFB1 Recombinant Antibody; Fab Fragment (TAB-633CT-F(E)) | ELISA, WB, FC, IP | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-635CT-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (TAB-635CT-S(P)) | ELISA, WB, FC, IP | Human scFv |
| TAB-636CT-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (TAB-636CT-S(P)) | ELISA, WB, FC, IP | Human scFv |
| TAB-637CT-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (TAB-637CT-S(P)) | ELISA, WB, FC, IP | Human scFv |
| TAB-638CT-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (TAB-638CT-S(P)) | ELISA, WB, FC, IP | Human scFv |
| TAB-639CT-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (TAB-639CT-S(P)) | ELISA, WB, FC, IP | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2018CT | Recombinant Mouse anti-Human TGFB1 Monoclonal antibody (3D6) | ELISA, WB | |
| HPAB-0492-CN | Human Anti-TGFB1 Recombinant Antibody (HPAB-0492-CN) | ELISA, FC, IF, Neut | Human IgG2 |
| HPAB-0493-CN | Human Anti-TGFB1 Recombinant Antibody (HPAB-0493-CN) | ELISA, FC, IF, Neut | Human IgG2 |
| HPAB-0494-CN | Human Anti-TGFB1 Recombinant Antibody (HPAB-0494-CN) | ELISA, Neut | Human IgG4 |
| HPAB-0495-CN | Human Anti-TGFB1 Recombinant Antibody (HPAB-0495-CN) | ELISA, Neut | Human IgG4 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0853MZ | Chicken Anti-TGF beta-1 Polyclonal IgY | ELISA, IHC, WB | Chicken antibody |
| BRD-1110MZ | Chicken Anti-Human TGF (beta) Polyclonal IgY Conjugated to PE-Cy5.5 | ELISA, WB, IHC, ICC, IF, IP, FC | Chicken antibody |
| BRD-1111MZ | Chicken Anti-Human TGF (beta) Polyclonal IgY Conjugated to PE-Cy7 | ELISA, WB, IHC, ICC, IF, IP, FC | Chicken antibody |
| BRD-1112MZ | Chicken Anti-Human TGF (beta) Polyclonal IgY Conjugated to PerCP | ELISA, WB, IHC, ICC, IF, IP, FC | Chicken antibody |
| BRD-1113MZ | Chicken Anti-Human TGF (beta) Polyclonal IgY Conjugated to PerCP-Cy5.5 | ELISA, WB, IHC, ICC, IF, IP, FC | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2003CQ | Mouse Anti-TGFB1 Recombinant Antibody (clone CBL443) | Neut | Mouse IgG1 |
| NEUT-2004CQ | Mouse Anti-Tgfb1 Recombinant Antibody (NEUT-2004CQ) | FC, WB, IP, Neut | Mouse IgG2b, κ |
| NEUT-2005CQ | Mouse Anti-Tgfb1 Recombinant Antibody (NEUT-2005CQ) | FC, IP, Neut, WB | Mouse IgG1, κ |
| NEUT-2006CQ | Mouse Anti-TGFB1 Recombinant Antibody (clone 1D11.16.8) | Neut | Mouse IgG1 |
| NEUT-2007CQ | Mouse Anti-TGFB1 Recombinant Antibody (NEUT-2007CQ) | IHC-Fr, WB, ELISA, IHC-Fr, Neut, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2009CQ | Mouse Anti-TGFB1 Recombinant Antibody (clone 9016.2) | ELISA, Inhib, WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3550 | Rabbit Anti-TGFB1 Recombinant Antibody (clone DS3550AB) | WB | Rabbit IgG |
| MOR-4451 | Rabbit Anti-TGFB1 Recombinant Antibody (clone SI544DS) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0018-YC-F(E) | Human Anti-TGFB1 Recombinant Antibody; Fab Fragment (HPAB-0018-YC-F(E)) | ELISA, Neut | Humanized Fab |
| HPAB-0492-CN-F(E) | Human Anti-TGFB1 Recombinant Antibody; Fab Fragment (HPAB-0492-CN-F(E)) | ELISA, FC, IF, Neut | Human Fab |
| HPAB-0493-CN-F(E) | Human Anti-TGFB1 Recombinant Antibody; Fab Fragment (HPAB-0493-CN-F(E)) | ELISA, FC, IF, Neut | Human Fab |
| HPAB-0494-CN-F(E) | Human Anti-TGFB1 Recombinant Antibody; Fab Fragment (HPAB-0494-CN-F(E)) | ELISA, Neut | Human Fab |
| HPAB-2101-FY-F(E) | Human Anti-TGFB1 Recombinant Antibody (clone SL15A); Fab Fragment | Inhib, ELISA | Human Fab, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0492-CN-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (HPAB-0492-CN-S(P)) | ELISA, FC, IF, Neut | Human scFv |
| HPAB-0493-CN-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (HPAB-0493-CN-S(P)) | ELISA, FC, IF, Neut | Human scFv |
| HPAB-0494-CN-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (HPAB-0494-CN-S(P)) | ELISA, Neut | Human scFv |
| HPAB-0495-CN-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (HPAB-0495-CN-S(P)) | ELISA, Neut | Human scFv |
| HPAB-0496-CN-S(P) | Human Anti-TGFB1 Recombinant Antibody; scFv Fragment (HPAB-0496-CN-S(P)) | ELISA, Neut | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-140 | Afuco™ Anti-TGFB1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-140) | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
| AFC-TAB-762 | Afuco™ Anti-TGFB1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-762) | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN1265 | PE-A*02:01/Human TGFB1 (RLSSCVPVA) MHC Tetramer | FCM, IHC | |
| MHC-CN1266 | APC-A*02:01/Human TGFB1 (RLSSCVPVA) MHC Tetramer | FCM, IHC | |
| MHC-CN1267 | FITC-A*02:01/Human TGFB1 (RLSSCVPVA) MHC Tetramer | FCM, IHC | |
| MHC-CN1268 | A*02:01/Human TGFB1 (RLSSCVPVA) MHC Tetramer | FCM, IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY252 | AbPlus™ Anti-TGFB1 Magnetic Beads (VS-0424-XY252) | IP, Protein Purification | |
| VS-0724-YC1506 | AbPlus™ Anti-TGFB1 Magnetic Beads (VS-0724-YC1506) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY503 | Mouse Anti-NHP TGFB1 Recombinant Antibody (clone 1D11.16.8) | WB, IF, ELISA | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY14 | Human Anti-TGFB1 (clone 31G9) scFv-Fc Chimera | ELISA, Block | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7208 | Anti-TGFB1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7209 | Anti-Mouse TGFB1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7210 | Anti-Rat TGFB1 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC230 | Recombinant Anti-TGFB1 Biparatopic Antibody, Tandem scFv | ELISA, FC, ICC, IF, IP, Neut | Tandem scFv |
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