Anti-TGFB1 Recombinant Antibody (TAB-762) (CAT#: TAB-762)
Recombinant human monoclonal antibody expressed in CHO binding to human TGFB1. It is a human IgG4 monoclonal antibody that neutralizes TGF beta 1 which had been chosen for further development for the treatment of diffuse cutaneous systemic sclerosis, also known as scleroderma.
Specific Inquiry
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol & the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73356/1901_C17_1_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol & the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73356/1901_C17_1_selected.jpg
Figure 2 IHC staining of human bone marrow
(Immunohistochemical staining of human bone marrow shows strong cytoplasmic positivity in bone marrow poietic cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/361/ihc_selected.jpg
(Immunohistochemical staining of human bone marrow shows strong cytoplasmic positivity in bone marrow poietic cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/361/ihc_selected.jpg
Figure 3 IF staining of human cell line HEL
(Immunofluorescent staining of human cell line HEL shows localization to Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73356/1812_G3_5_cr5a09c41109818_blue_red_green.jpg
(Immunofluorescent staining of human cell line HEL shows localization to Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73356/1812_G3_5_cr5a09c41109818_blue_red_green.jpg
Figure 4 Bone marrow
(Hematopoietic cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/361/2675_B_6_4.jpg
(Hematopoietic cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/361/2675_B_6_4.jpg
Figure 5 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000105329-TGFB1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000105329-TGFB1
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Human
- Type
- IgG4 - kappa
- Species Reactivity
- Human
- Applications
- Suitable for use in IF, IP, Neut, FuncS, ELISA, FC, ICC and most other immunological methods.
- Related Disease
- Scarring
Product Property
- Purity
- >95.0% as determined by analysis by SDS-PAGE.
- Storage
- Store it under sterile conditions at -20°C upon receiving. Recommend to pack the protein into smaller quantities for optimal storage.
Target
- Alternative Names
- metelimumab;272780-74-2;CAT-192;TGFB1;transforming growth factor, beta 1;DPD1, TGFB;transforming growth factor beta-1;Camurati Engelmann disease;CED;TGFbeta;TGF-beta-1;TGF-beta 1 protein;latency-associated peptide;LAP;DPD1;TGFB;
- Gene ID
- 7040
- UniProt ID
- P01137
Related Resources
Please refer to Metelimumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Metelimumab.
Inflammatory Bowel Diseases
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-140 | Anti-Human TGF-β Recombinant Antibody (TAB-140) | Neut, ELISA, IF, IP, FuncS, FC, ICC | IgG4 - kappa |
| TAB-635CT | Human Anti-TGFB1 Recombinant Antibody (TAB-635CT) | ELISA, WB, FC, IP | Human IgG |
| TAB-636CT | Human Anti-TGFB1 Recombinant Antibody (TAB-636CT) | ELISA, WB, FC, IP | Human IgG |
| TAB-637CT | Human Anti-TGFB1 Recombinant Antibody (TAB-637CT) | ELISA, WB, FC, IP | Human IgG |
| TAB-638CT | Human Anti-TGFB1 Recombinant Antibody (TAB-638CT) | ELISA, WB, FC, IP | Human IgG1 |
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Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TAB-762, RRID: AB_3112006)
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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